scholarly journals Antimicrobial peptide LL-37 promotes the proliferation and invasion of skin squamous cell carcinoma by upregulating DNA-binding protein A

2016 ◽  
Vol 12 (3) ◽  
pp. 1745-1752 ◽  
Author(s):  
Wei Wang ◽  
Jinjing Jia ◽  
Changji Li ◽  
Qiqi Duan ◽  
Jiao Yang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Dna Binding ◽  
Antimicrobial Peptide ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Binding Protein ◽  
Protein A ◽  
Dna Binding Protein ◽  
Skin Squamous Cell Carcinoma ◽  
Proliferation And Invasion

scholarly journals A missense mutation in damage-specific DNA binding protein 2 is a genetic risk factor for limbal squamous cell carcinoma in horses

2017 ◽  
Vol 141 (2) ◽  
pp. 342-353 ◽  
Author(s):  
Rebecca R. Bellone ◽  
Jiayin Liu ◽  
Jessica L. Petersen ◽  
Maura Mack ◽  
Moriel Singer-Berk ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Risk Factor ◽  
Dna Binding ◽  
Cell Carcinoma ◽  
Missense Mutation ◽  
Squamous Cell ◽  
Genetic Risk ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Genetic Risk Factor

scholarly journals Knockdown of Ubiquitin-Specific Protease 53 Enhances the Radiosensitivity of Human Cervical Squamous Cell Carcinoma by Regulating DNA Damage-Binding Protein 2

2020 ◽  
Vol 19 ◽  
pp. 153303382092979
Author(s):  
Qifen Zhou ◽  
Xiongbo Yao ◽  
Chunlin Wu ◽  
Shaohua Chen ◽  
Dage Fan
Keyword(s):  
Cell Cycle ◽  
Squamous Cell Carcinoma ◽  
Dna Binding ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Binding Protein ◽  
Cervical Squamous Cell Carcinoma ◽  
Dna Binding Protein ◽  
Specific Protein ◽  
Cycle Arrest

Background: Cervical cancer ranks fourth in incidence and mortality among women. Ubiquitin-specific protein 53 binds to damage-specific DNA binding protein 2 and affects the biological properties of colon cancer. Damage-specific DNA binding protein is involved in nucleotide excision repair, which can repair DNA damage. However, the mechanism by which ubiquitin-specific protein 53 regulates the radiosensitivity of cervical cancer through damage-specific DNA binding protein remains unclear. Methods: Tissue samples from 40 patients with cervical squamous cell carcinoma who received radiotherapy were examined by immunohistochemistry to detect the expression of ubiquitin-specific protein 53, and clinical data were collected for statistical analysis. The cell cycle was detected by flow cytometry in Siha cells transfected with Si-USP53 and exposed to 8 Gy irradiation. Cell viability was determined by the CCK8 method in cells transfected with Si-USP53 and exposed to 0, 2, 4, 6, 8, or 10 Gy. The expression of damage-specific DNA binding protein, cyclin-dependent kinase 1, and cell cycle checkpoint kinase 2 was detected in cells transfected with Si-USP53. Results: The expression of ubiquitin-specific protein 53 in the tissues of patients with cervical squamous cell carcinoma was correlated with the sensitivity to radiotherapy. Knockdown of ubiquitin-specific protein 53 in Siha cells downregulated damage-specific DNA binding protein and caused G2/M cell cycle arrest and decreased the survival rate of cells in response to radiation. Conclusion: Ubiquitin-specific protein 53–induced cell cycle arrest and affected the radiotherapy sensitivity of tumors through damage-specific DNA binding protein.

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