scholarly journals Gastrointestinal tract spindle cell tumors with interstitial cells of Cajal: Prevalence excluding gastrointestinal stromal tumors

2016 ◽  
Vol 12 (2) ◽  
pp. 1287-1292 ◽  
Author(s):  
So Jung Lee ◽  
Chung Su Hwang ◽  
Ahrong Kim ◽  
Kyungbin Kim ◽  
Kyung Un Choi
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Spindle Cell ◽  
Interstitial Cells ◽  
Stromal Tumors ◽  
Spindle Cell Tumors ◽  
Cells Of Cajal

scholarly journals Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST)

Oncotarget ◽  
2017 ◽  
Vol 8 (25) ◽  
pp. 41026-41043 ◽  
Author(s):  
Pierre Vandenberghe ◽  
Perrine Hagué ◽  
Steven C. Hockman ◽  
Vincent C. Manganiello ◽  
Pieter Demetter ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumors ◽  
Cells Of Cajal

266 Accelerated Turnover of Interstitial Cells of Cajal (ICC) from Local Progenitors in a Mouse Model of Gastrointestinal Stromal Tumors (GIST)

2009 ◽  
Vol 136 (5) ◽  
pp. A-51
Author(s):  
Michael R. Bardsley ◽  
Laura Popko ◽  
David L. Young ◽  
Gianrico Farrugia ◽  
Brian P. Rubin ◽  
...  
Keyword(s):  
Mouse Model ◽  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumors ◽  
Cells Of Cajal

Large Omental Metastases of a Gastrointestinal Stromal Tumor

Medicina ◽  
2011 ◽  
Vol 47 (11) ◽  
pp. 86
Author(s):  
Povilas Ignatavičius ◽  
Tomas Petraitis ◽  
Žilvinas Saladžinskas ◽  
Lilija Butkevičienė ◽  
Kristina Žvinienė
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Metastatic Tumor ◽  
Stromal Tumor ◽  
Mesenchymal Tumors ◽  
Stromal Tumors ◽  
Cells Of Cajal

Gastrointestinal stromal tumors are rare tumors, originating from the interstitial cells of Cajal. They are the most common mesenchymal tumors of the gastrointestinal tract. Metastatic tumor is treated with imatinib mesylate. A case of large metastases of a gastrointestinal stromal tumor to the omentum, diagnosis and treatment principles are presented in this case report.

scholarly journals Expression of the Intermediate Filament Nestin in Gastrointestinal Stromal Tumors and Interstitial Cells of Cajal

2001 ◽  
Vol 158 (3) ◽  
pp. 817-823 ◽  
Author(s):  
Tohru Tsujimura ◽  
Chiaki Makiishi-Shimobayashi ◽  
Johan Lundkvist ◽  
Urban Lendahl ◽  
Keiji Nakasho ◽  
...  
Keyword(s):  
Intermediate Filament ◽  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumors ◽  
Cells Of Cajal

Interstitial Cells of Cajal as Precursors of Gastrointestinal Stromal Tumors

1999 ◽  
Vol 23 (4) ◽  
pp. 377-389 ◽  
Author(s):  
K. Sircar ◽  
B. R. Hewlett ◽  
J. D. Huizinga ◽  
K. Chorneyko ◽  
I. Berezin ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumors ◽  
Cells Of Cajal

scholarly journals Neurotensin Receptor 1 Is Expressed in Gastrointestinal Stromal Tumors but Not in Interstitial Cells of Cajal

PLoS ONE ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. e14710 ◽  
Author(s):  
Petra Gromova ◽  
Brian P. Rubin ◽  
An Thys ◽  
Christophe Erneux ◽  
Jean-Marie Vanderwinden
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumors ◽  
Neurotensin Receptor ◽  
Cells Of Cajal ◽  
Neurotensin Receptor 1

scholarly journals Orai1 mediates tumor-promoting store-operated Ca2+ entry in human gastrointestinal stromal tumors via c-KIT and the extracellular signal–regulated kinase pathway

Tumor Biology ◽  
2017 ◽  
Vol 39 (2) ◽  
pp. 101042831769142 ◽  
Author(s):  
Lei Wang ◽  
Jiaqi Hao ◽  
Yijian Zhang ◽  
Ziyi Yang ◽  
Yang Cao ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumor ◽  
Extracellular Signal Regulated Kinase ◽  
Stromal Tumors ◽  
Extracellular Signal ◽  
Cells Of Cajal

Gastrointestinal stromal tumors originate from interstitial cells of Cajal, the pacemaker cells of the gut. Ca2+ regulates the pacemaker activity of interstitial cells of Cajal. Store-operated Ca2+ entry mediates the majority of Ca2+ entry in most cancer cells and may be a factor in regulating intracellular Ca2+ in interstitial cells of Cajal and gastrointestinal stromal tumors. Therefore, a blockade of this mechanism may affect the progression of gastrointestinal stromal tumors. Orai1 is the pore subunit of store-operated Ca2+ channels. Here, we reported that Orai1 was overexpressed in gastrointestinal stromal tumor tissues and was positively correlated with a high-risk grade in gastrointestinal stromal tumor patients. Furthermore, upon Orai1 silencing, the functional store-operated Ca2+ entry in gastrointestinal stromal tumor cells was decreased, indicating that the function of store-operated Ca2+ entry was mediated by Orai1. Inhibition of Orai1-mediated store-operated Ca2+ entry by Orai1 silencing or store-operated Ca2+ entry blockers (SKF-96365 and 2-aminoethyl diphenylborate) induced obvious cell proliferation suppression, cell-cycle distribution, and apoptosis stimulation in GIST-T1 cells. Conversely, Orai1 overexpression increased store-operated Ca2+ entry and cell proliferation in GIST882 cells. In addition, we found that activation of c-KIT and the extracellular signal–regulated kinase pathway participated in the oncogenic functions of Orai1-mediated store-operated Ca2+ entry in gastrointestinal stromal tumor cells. These results revealed that Orai1-mediated store-operated Ca2+ entry is critical for gastrointestinal stromal tumor cell proliferation via c-KIT and ERK signaling pathway activation. Orai1-mediated store-operated Ca2+ entry plays an oncogenic role and may be a novel prognostic factor and therapeutic target for patients with gastrointestinal stromal tumors.

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