scholarly journals Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST)

Oncotarget ◽  
2017 ◽  
Vol 8 (25) ◽  
pp. 41026-41043 ◽  
Author(s):  
Pierre Vandenberghe ◽  
Perrine Hagué ◽  
Steven C. Hockman ◽  
Vincent C. Manganiello ◽  
Pieter Demetter ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumors ◽  
Cells Of Cajal

266 Accelerated Turnover of Interstitial Cells of Cajal (ICC) from Local Progenitors in a Mouse Model of Gastrointestinal Stromal Tumors (GIST)

2009 ◽  
Vol 136 (5) ◽  
pp. A-51
Author(s):  
Michael R. Bardsley ◽  
Laura Popko ◽  
David L. Young ◽  
Gianrico Farrugia ◽  
Brian P. Rubin ◽  
...  
Keyword(s):  
Mouse Model ◽  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumors ◽  
Cells Of Cajal

scholarly journals Expression of the Intermediate Filament Nestin in Gastrointestinal Stromal Tumors and Interstitial Cells of Cajal

2001 ◽  
Vol 158 (3) ◽  
pp. 817-823 ◽  
Author(s):  
Tohru Tsujimura ◽  
Chiaki Makiishi-Shimobayashi ◽  
Johan Lundkvist ◽  
Urban Lendahl ◽  
Keiji Nakasho ◽  
...  
Keyword(s):  
Intermediate Filament ◽  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumors ◽  
Cells Of Cajal

Interstitial Cells of Cajal as Precursors of Gastrointestinal Stromal Tumors

1999 ◽  
Vol 23 (4) ◽  
pp. 377-389 ◽  
Author(s):  
K. Sircar ◽  
B. R. Hewlett ◽  
J. D. Huizinga ◽  
K. Chorneyko ◽  
I. Berezin ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumors ◽  
Cells Of Cajal

scholarly journals Neurotensin Receptor 1 Is Expressed in Gastrointestinal Stromal Tumors but Not in Interstitial Cells of Cajal

PLoS ONE ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. e14710 ◽  
Author(s):  
Petra Gromova ◽  
Brian P. Rubin ◽  
An Thys ◽  
Christophe Erneux ◽  
Jean-Marie Vanderwinden
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumors ◽  
Neurotensin Receptor ◽  
Cells Of Cajal ◽  
Neurotensin Receptor 1

scholarly journals Orai1 mediates tumor-promoting store-operated Ca2+ entry in human gastrointestinal stromal tumors via c-KIT and the extracellular signal–regulated kinase pathway

Tumor Biology ◽  
2017 ◽  
Vol 39 (2) ◽  
pp. 101042831769142 ◽  
Author(s):  
Lei Wang ◽  
Jiaqi Hao ◽  
Yijian Zhang ◽  
Ziyi Yang ◽  
Yang Cao ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumor ◽  
Extracellular Signal Regulated Kinase ◽  
Stromal Tumors ◽  
Extracellular Signal ◽  
Cells Of Cajal

Gastrointestinal stromal tumors originate from interstitial cells of Cajal, the pacemaker cells of the gut. Ca2+ regulates the pacemaker activity of interstitial cells of Cajal. Store-operated Ca2+ entry mediates the majority of Ca2+ entry in most cancer cells and may be a factor in regulating intracellular Ca2+ in interstitial cells of Cajal and gastrointestinal stromal tumors. Therefore, a blockade of this mechanism may affect the progression of gastrointestinal stromal tumors. Orai1 is the pore subunit of store-operated Ca2+ channels. Here, we reported that Orai1 was overexpressed in gastrointestinal stromal tumor tissues and was positively correlated with a high-risk grade in gastrointestinal stromal tumor patients. Furthermore, upon Orai1 silencing, the functional store-operated Ca2+ entry in gastrointestinal stromal tumor cells was decreased, indicating that the function of store-operated Ca2+ entry was mediated by Orai1. Inhibition of Orai1-mediated store-operated Ca2+ entry by Orai1 silencing or store-operated Ca2+ entry blockers (SKF-96365 and 2-aminoethyl diphenylborate) induced obvious cell proliferation suppression, cell-cycle distribution, and apoptosis stimulation in GIST-T1 cells. Conversely, Orai1 overexpression increased store-operated Ca2+ entry and cell proliferation in GIST882 cells. In addition, we found that activation of c-KIT and the extracellular signal–regulated kinase pathway participated in the oncogenic functions of Orai1-mediated store-operated Ca2+ entry in gastrointestinal stromal tumor cells. These results revealed that Orai1-mediated store-operated Ca2+ entry is critical for gastrointestinal stromal tumor cell proliferation via c-KIT and ERK signaling pathway activation. Orai1-mediated store-operated Ca2+ entry plays an oncogenic role and may be a novel prognostic factor and therapeutic target for patients with gastrointestinal stromal tumors.

scholarly journals C-kitGene Abnormalities in Gastrointestinal Stromal Tumors (Tumors of Interstitial Cells of Cajal)

1999 ◽  
Vol 90 (12) ◽  
pp. 1321-1328 ◽  
Author(s):  
Shinji Sakurai ◽  
Tomoki Fukasawa ◽  
Ja-Mun Chong ◽  
Akira Tanaka ◽  
Masashi Fukayama
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumors ◽  
Cells Of Cajal

Interstitial cells of Cajal do not harbor c-kit or PDGFRA gene mutations in patients with sporadic gastrointestinal stromal tumors

2009 ◽  
Vol 44 (5) ◽  
pp. 426-431 ◽  
Author(s):  
Takahiko Nakajima ◽  
Shigeharu Miwa ◽  
Takayuki Ando ◽  
Haruka Fujinami ◽  
Shinya Kajiura ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Gene Mutations ◽  
Interstitial Cells ◽  
Stromal Tumors ◽  
Pdgfra Gene ◽  
Cells Of Cajal
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