scholarly journals Complete response to abdominal bulky lymph node recurrence in an esophageal cancer patient treated with S-1 monotherapy: A case report

2016 ◽  
Vol 11 (6) ◽  
pp. 3901-3903
Author(s):  
ATSUTO KATANO ◽  
HIDEOMI YAMASHITA ◽  
KAE OKUMA ◽  
KEIICHI NAKAGAWA
2020 ◽  
Vol 27 (3) ◽  
pp. 220-226
Author(s):  
Junghwa Do ◽  
One-bin Lim ◽  
Ja-young Kim ◽  
Jae Yong Jeon ◽  
Young-ki Cho

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Masaaki Saito ◽  
Hirokazu Kiyozaki ◽  
Tamotu Obitsu ◽  
Hirofumi Imoto ◽  
Yusuke Taniyama ◽  
...  

2020 ◽  
Vol 13 (6) ◽  
pp. 1041-1045
Author(s):  
Tomonori Nakanoko ◽  
Masaru Morita ◽  
Kenichi Taguchi ◽  
Naonobu Kunitake ◽  
Hideo Uehara ◽  
...  

2018 ◽  
Vol 25 (7) ◽  
pp. 1767-1775 ◽  
Author(s):  
Hiroyuki Amagai ◽  
Kentaro Murakami ◽  
Haruhito Sakata ◽  
Masaya Uesato ◽  
Koichi Hayano ◽  
...  

Introduction Cancer patients undergoing hemodialysis might be under-treated because the pharmacokinetics of anti-cancer drugs in such patients remain unknown and out of concern related to the potential development of severe adverse effects. However, patients with chemosensitive cancer, such as esophageal cancer, should receive chemotherapy at a dose that is sufficient to attain a favorable therapeutic effect. We herein present an interesting case involving an esophageal cancer patient who was successfully treated with subtotal thoracic esophagectomy, and adjuvant full-dose chemotherapy with cisplatin and 5-fluorouracil while concomitantly undergoing hemodialysis. We carried out a pharmacokinetics analysis of cisplatin, and also conducted a systematic review on the dose and pharmacokinetics. Case report A 57-year-old male patient with esophageal cancer who was undergoing hemodialysis was referred to our hospital. He underwent subtotal thoracic esophagectomy. The pathological diagnosis was T1b, N2 (5/26), M0, ly2, v2, stage IIIA (Union for International Cancer Control, 8th edition). Because of the high degree of lymph node metastasis, adjuvant chemotherapy with cisplatin was recommended. Cisplatin (80 mg/m2) was infused intravenously within 30 min on day 1, and 5-fluorouracil (800 mg/m2) was infused continuously on days 1–5 of a 28-day cycle. Thrombocytopenia (grade 3) occurred on day 16, leucopenia (grade 3) occurred on day 23, and anemia (grade 3) occurred on day 30. The onset of hematologic toxicities was prolonged in comparison to patients with a normal renal function.


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