scholarly journals Extracellular matrix metalloproteinase inducer and matrix metalloproteinase-2 overexpression is associated with loss of hormone receptor expression and poor prognosis in endometrial cancer

2015 ◽  
Vol 10 (1) ◽  
pp. 342-348 ◽  
Author(s):  
YUAN YUAN ◽  
NING SHEN ◽  
SHU-YAN YANG ◽  
LING ZHAO ◽  
YONG-MEI GUAN
Keyword(s):  
Extracellular Matrix ◽  
Endometrial Cancer ◽  
Matrix Metalloproteinase ◽  
Hormone Receptor ◽  
Poor Prognosis ◽  
Receptor Expression ◽  
Matrix Metalloproteinase 2 ◽  
Extracellular Matrix Metalloproteinase Inducer ◽  
Hormone Receptor Expression

High extracellular matrix metalloproteinase inducer/CD147 expression is strongly and independently associated with poor prognosis in colorectal cancer

2012 ◽  
Vol 43 (9) ◽  
pp. 1471-1481 ◽  
Author(s):  
Albrecht Stenzinger ◽  
Daniel Wittschieber ◽  
Moritz von Winterfeld ◽  
Benjamin Goeppert ◽  
Carsten Kamphues ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Extracellular Matrix ◽  
Matrix Metalloproteinase ◽  
Poor Prognosis ◽  
Extracellular Matrix Metalloproteinase Inducer ◽  
Cd147 Expression

scholarly journals EphA2 overexpression is associated with lack of hormone receptor expression and poor outcome in endometrial cancer

Cancer ◽  
2009 ◽  
Vol 115 (12) ◽  
pp. 2684-2692 ◽  
Author(s):  
Aparna A. Kamat ◽  
Donna Coffey ◽  
William M. Merritt ◽  
Elizabeth Nugent ◽  
Diana Urbauer ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Hormone Receptor ◽  
Receptor Expression ◽  
Poor Outcome ◽  
Hormone Receptor Expression

scholarly journals Hormone receptor expression in human fascial tissue

2016 ◽  
Author(s):  
C. Fede ◽  
G. Albertin ◽  
L. Petrelli ◽  
M.M. Sfriso ◽  
C. Biz ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Hormone Receptor ◽  
Hormone Receptors ◽  
Myofascial Pain ◽  
Sex Hormone ◽  
Receptor Expression ◽  
Adult Women ◽  
Hormonal Factors ◽  
Hormone Receptor Expression ◽  
Post Menopausal

Many epidemiologic, clinical, and experimental findings point to sex differences in myofascial pain in view of the fact that adult women tend to have more myofascial problems with respect to men. It is possible that one of the stimuli to sensitization of fascial nociceptors could come from hormonal factors such as estrogen and relaxin, that are involved in extracellular matrix and collagen remodeling and thus contribute to functions of myofascial tissue. Immunohistochemical and molecular investigations (real-time PCR analysis) of relaxin receptor 1 (RXFP1) and estrogen receptor-alpha (ERα) localization were carried out on sample of human fascia collected from 8 volunteers patients during orthopedic surgery (all females, between 42 and 70 yrs, divided into pre- and post-menopausal groups), and in fibroblasts isolated from deep fascia, to examine both protein and RNA expression levels. We can assume that the two sex hormone receptors analyzed are expressed in all the human fascial districts examined and in fascial fibroblasts culture cells, to a lesser degree in the post-menopausal with respect to the pre-menopausal women. Hormone receptor expression was concentrated in the fibroblasts, and RXFP1 was also evident in blood vessels and nerves. Our results are the first demonstrating that the fibroblasts located within different districts of the muscular fasciae express sex hormone receptors and can help to explain the link between hormonal factors and myofascial pain. It is known, in fact, that estrogen and relaxin play a key role in extracellular matrix remodeling by inhibiting fibrosis and inflammatory activities, both important factors affecting fascial stiffness and sensitization of fascial nociceptors.

Prognostic Significance of Extracellular Matrix Metalloproteinase Inducer and Matrix Metalloproteinase 2 in Epithelial Ovarian Cancer

Tumor Biology ◽  
2007 ◽  
Vol 28 (5) ◽  
pp. 280-289 ◽  
Author(s):  
S. Sillanpää ◽  
M. Anttila ◽  
K. Suhonen ◽  
K. Hämäläinen ◽  
T. Turpeenniemi-Hujanen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Extracellular Matrix ◽  
Matrix Metalloproteinase ◽  
Epithelial Ovarian Cancer ◽  
Prognostic Significance ◽  
Matrix Metalloproteinase 2 ◽  
Extracellular Matrix Metalloproteinase Inducer
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