scholarly journals Upregulation of Toll-like receptor 2 expression in colorectal cancer infected by human cytomegalovirus

2014 ◽  
Vol 9 (1) ◽  
pp. 365-370 ◽  
Author(s):  
XUTONG LI ◽  
DONGMENG QIAN ◽  
FANG JU ◽  
BIN WANG
Keyword(s):  
Colorectal Cancer ◽  
Human Cytomegalovirus ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

Microsatelite GT polymorphism in the toll-like receptor 2 is associated with colorectal cancer

2006 ◽  
Vol 70 (2) ◽  
pp. 156-160 ◽  
Author(s):  
T Boraska Jelavić ◽  
M Barišić ◽  
I Drmic Hofman ◽  
V Boraska ◽  
E Vrdoljak ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

scholarly journals Relationship between Arg753Gln Toll-like receptor 2 and Asp299Gly Toll-like receptor 4 genetic variations and susceptibility to colorectal cancer in Southern Iran

2018 ◽  
Vol 70 (4) ◽  
pp. 775-779 ◽  
Author(s):  
Seyed Hosseini ◽  
Zahra Mojtahedi ◽  
Zahra Beizavi ◽  
Hajar Khazraei ◽  
Mozhdeh Zamani
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Inflammatory Responses ◽  
Tumor Stage ◽  
Nucleotide Polymorphisms ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Southern Iran ◽  
Toll Like Receptor 2 ◽  
Colorectal Cancer Patients

Variations in Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) encoding genes have been associated with tumorigenesis through the disruption of immune and inflammatory responses. The aims of this study were to evaluate the two single nucleotide polymorphisms (SNPs) of the genes Arg753Gln TLR2 (rs5743708) and Asp299Gly TLR4 (rs4986790) in colorectal cancer patients in southern Iran. Colorectal cancer patients and healthy controls were included in this study (150 Persian subjects in each group). Blood samples were used for genotyping by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The association between these SNPs and colorectal cancer and clinicopathological factors, including age, gender, tumor stage and differentiation were also investigated. A significant association was found between Arg753Gln TLR2 SNP and colorectal cancer. This SNP was significantly more frequent in male patients. However, there was no association between Asp299Gly TLR4 and colorectal cancer. Therefore, Arg753Gln TLR2 SNP can be considered as a risk factor for colorectal cancer incidence in southern Iran, especially in men. Further investigations in other populations are recommended in order to assess the association of this SNP with colorectal cancer.

scholarly journals Toll-Like Receptor 2-Mediated Suppression of Colorectal Cancer Pathogenesis by Polysaccharide A From Bacteroides fragilis

2018 ◽  
Vol 9 ◽  
Author(s):  
Panida Sittipo ◽  
Stefani Lobionda ◽  
Kyungchul Choi ◽  
Ita Novita Sari ◽  
Hyog Young Kwon ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Bacteroides Fragilis ◽  
Toll Like Receptor ◽  
Cancer Pathogenesis ◽  
Toll Like Receptor 2

scholarly journals The R753Q Polymorphism Abrogates Toll‐Like Receptor 2 Signaling in Response to Human Cytomegalovirus

2009 ◽  
Vol 49 (9) ◽  
pp. e96-e99 ◽  
Author(s):  
Robert A. Brown ◽  
Jonathon H. Gralewski ◽  
Raymund R. Razonable
Keyword(s):  
Human Cytomegalovirus ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

Human Cytomegalovirus Interacts with Toll-like Receptor 2 and CD14 on Syncytiotrophoblasts to Stimulate Expression of TNFα mRNA and Apoptosis

Placenta ◽  
2009 ◽  
Vol 30 (11) ◽  
pp. 994-1001 ◽  
Author(s):  
S. Chaudhuri ◽  
B. Lowen ◽  
G. Chan ◽  
A. Davey ◽  
M. Riddell ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

scholarly journals Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2

2003 ◽  
Vol 77 (8) ◽  
pp. 4588-4596 ◽  
Author(s):  
Teresa Compton ◽  
Evelyn A. Kurt-Jones ◽  
Karl W. Boehme ◽  
John Belko ◽  
Eicke Latz ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Human Cytomegalovirus ◽  
Inflammatory Cytokine ◽  
Protein S ◽  
Opportunistic Pathogen ◽  
Innate Immune ◽  
Cell Contact ◽  
Toll Like Receptor ◽  
Interferon Stimulated Genes ◽  
Toll Like Receptor 2

ABSTRACT Human cytomegalovirus (CMV) is a ubiquitous opportunistic pathogen that causes significant morbidity and mortality in immuncompromised people. An understanding of how CMV induces and circumvents host immunity is of critical importance in efforts to design effective therapeutics. It was recently discovered that mere cell contact by CMV particles leads to profound modulation of cellular gene expression, including induction of inflammatory cytokines and interferon-stimulated genes characteristic of innate immune detection. These findings suggest that a membrane receptor recognizes a CMV envelope protein(s), leading to innate immune activation. Here, we show that the pattern recognition receptors Toll-like receptor 2 (TLR2) and CD14 recognize CMV virions and trigger inflammatory cytokine production. Induction of inflammatory cytokines is mediated via TLR2-dependent activation of NF-κB. Since many of the pathological processes associated with CMV disease are facilitated or directly mediated by inflammatory cytokines, identification of the host membrane detection machinery may ultimately lead to improved therapeutics.

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