scholarly journals The R753Q Polymorphism Abrogates Toll‐Like Receptor 2 Signaling in Response to Human Cytomegalovirus

2009 ◽  
Vol 49 (9) ◽  
pp. e96-e99 ◽  
Author(s):  
Robert A. Brown ◽  
Jonathon H. Gralewski ◽  
Raymund R. Razonable
Keyword(s):  
Human Cytomegalovirus ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

Human Cytomegalovirus Interacts with Toll-like Receptor 2 and CD14 on Syncytiotrophoblasts to Stimulate Expression of TNFα mRNA and Apoptosis

Placenta ◽  
2009 ◽  
Vol 30 (11) ◽  
pp. 994-1001 ◽  
Author(s):  
S. Chaudhuri ◽  
B. Lowen ◽  
G. Chan ◽  
A. Davey ◽  
M. Riddell ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

scholarly journals Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2

2003 ◽  
Vol 77 (8) ◽  
pp. 4588-4596 ◽  
Author(s):  
Teresa Compton ◽  
Evelyn A. Kurt-Jones ◽  
Karl W. Boehme ◽  
John Belko ◽  
Eicke Latz ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Human Cytomegalovirus ◽  
Inflammatory Cytokine ◽  
Protein S ◽  
Opportunistic Pathogen ◽  
Innate Immune ◽  
Cell Contact ◽  
Toll Like Receptor ◽  
Interferon Stimulated Genes ◽  
Toll Like Receptor 2

ABSTRACT Human cytomegalovirus (CMV) is a ubiquitous opportunistic pathogen that causes significant morbidity and mortality in immuncompromised people. An understanding of how CMV induces and circumvents host immunity is of critical importance in efforts to design effective therapeutics. It was recently discovered that mere cell contact by CMV particles leads to profound modulation of cellular gene expression, including induction of inflammatory cytokines and interferon-stimulated genes characteristic of innate immune detection. These findings suggest that a membrane receptor recognizes a CMV envelope protein(s), leading to innate immune activation. Here, we show that the pattern recognition receptors Toll-like receptor 2 (TLR2) and CD14 recognize CMV virions and trigger inflammatory cytokine production. Induction of inflammatory cytokines is mediated via TLR2-dependent activation of NF-κB. Since many of the pathological processes associated with CMV disease are facilitated or directly mediated by inflammatory cytokines, identification of the host membrane detection machinery may ultimately lead to improved therapeutics.

Toll-like receptor 2 signaling is important for fas ligand on NKT cells, may contribute to liver injury induced by Salmonella infection

2001 ◽  
Vol 120 (5) ◽  
pp. A357-A357
Author(s):  
H SHIMIZU ◽  
Y FUKUDA ◽  
I NAKANO ◽  
Y KATANO ◽  
K NAGANO ◽  
...  
Keyword(s):  
Liver Injury ◽  
Fas Ligand ◽  
Nkt Cells ◽  
Toll Like Receptor ◽  
Salmonella Infection ◽  
Toll Like Receptor 2
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