scholarly journals Reversible posterior leukoencephalopathy syndrome during sunitinib therapy for metastatic renal cell carcinoma

2012 ◽  
Vol 3 (6) ◽  
pp. 1293-1296 ◽  
Author(s):  
JAMAL OULAD HADJ ◽  
ROGIER DEN BRAVEN ◽  
CORRINE TILLIER ◽  
HANS M. SCHRIJVER ◽  
HENK M.W. VERHEUL ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Reversible Posterior Leukoencephalopathy Syndrome ◽  
Reversible Posterior Leukoencephalopathy ◽  
Posterior Leukoencephalopathy

scholarly journals Reversible Posterior Leukoencephalopathy Syndrome Developing After Restart of Sunitinib Therapy for Metastatic Renal Cell Carcinoma

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Shinji Fukui ◽  
Yuta Toyoshima ◽  
Takeshi Inoue ◽  
Yoriaki Kagebayashi ◽  
Shoji Samma
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Vision Loss ◽  
Early Recognition ◽  
Antihypertensive Agents ◽  
Reversible Posterior Leukoencephalopathy Syndrome ◽  
Neurological Damage ◽  
Reversible Posterior Leukoencephalopathy ◽  
Posterior Leukoencephalopathy

A 64-year-old Japanese man had started molecular-targeted therapy with sunitinib for lymph node metastasis 5 years after nephrectomy for left renal cell carcinoma (clear cell carcinoma, G2, pT2N0M0). He was transported to our emergency department because of generalized tonic-clonic seizure, vision loss, and impaired consciousness with acute hypertension after 8 cycles of treatment (2 years after the initiation of sunitinib therapy, including a drug withdrawal period for one year). MRI of the brain (FLAIR images) showed multiple high-intensity lesions in the white matter of the occipital and cerebellar lobes, dorsal brain stem, and left thalamus. Reversible posterior leukoencephalopathy syndrome caused by sunitinib was suspected. In addition to the immediate discontinuation of sunitinib therapy, the administration of antihypertensive agents and anticonvulsants improved the clinical symptoms without neurological damage. Physicians should be aware that sunitinib causes reversible posterior leukoencephalopathy syndrome. The early recognition of reversible posterior leukoencephalopathy syndrome is critical to avoid irreversible neurological damage.

1103: Laparoscopic Salvage Nephrectomy after Targeted Neoadjuvant Therapy for Metastatic Renal Cell Carcinoma: Initial Results

2007 ◽  
Vol 177 (4S) ◽  
pp. 364-364 ◽  
Author(s):  
Surena F. Matin ◽  
Christopher G. Wood ◽  
Shi-Ming Tu ◽  
Nizar M. Tannir ◽  
Eric Jonasch
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neoadjuvant Therapy ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Initial Results

637: Establishing a Porcine Model for the Accelerated Development of Cancer Vaccines for Patients with Metastatic Renal Cell Carcinoma

2005 ◽  
Vol 173 (4S) ◽  
pp. 173-174
Author(s):  
Quinton V. Cancel ◽  
Benjamin K. Yang ◽  
Zhen Su ◽  
Jens Dannull ◽  
Philipp Dahm ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Cancer Vaccines ◽  
Porcine Model

1716: Pharmaco-Angio-CT is Superior to 4 Phase Helical CT in the Detection of Recurrent Metastatic Renal Cell Carcinoma

2006 ◽  
Vol 175 (4S) ◽  
pp. 551-552
Author(s):  
Erich K. Lang ◽  
Richard J. Macchia ◽  
Raju Thomas ◽  
Ronald Davis ◽  
Douglas Slakey ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Helical Ct ◽  
Angio Ct

396: HSP27 Expression in Primary and Metastatic Renal Cell Carcinoma

2006 ◽  
Vol 175 (4S) ◽  
pp. 129-129
Author(s):  
Richard E. Zigeuner ◽  
Nikolaus Droschl ◽  
Volkmar Tauber ◽  
Peter Rehak ◽  
Cord Langner
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Hsp27 Expression

392: Osteopontin Expression in Metastatic Renal Cell Carcinoma

2006 ◽  
Vol 175 (4S) ◽  
pp. 128-128
Author(s):  
Adrienne J.K. Carmack ◽  
Daniel Saenz ◽  
Merce Jorda ◽  
Thomas Temple ◽  
Balakrishna L. Lokeshwar
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Osteopontin Expression
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