scholarly journals Sorafenib-induced reversible posterior leukoencephalopathy in patients with renal cell carcinoma: A report of two cases

2017 ◽  
Author(s):  
Nobuki Furubayashi ◽  
Takahito Negishi ◽  
Hidenori Iwai ◽  
Kei Nagase ◽  
Motonobu Nakamura
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Reversible Posterior Leukoencephalopathy ◽  
Posterior Leukoencephalopathy

scholarly journals Reversible Posterior Leukoencephalopathy Syndrome Developing After Restart of Sunitinib Therapy for Metastatic Renal Cell Carcinoma

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Shinji Fukui ◽  
Yuta Toyoshima ◽  
Takeshi Inoue ◽  
Yoriaki Kagebayashi ◽  
Shoji Samma
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Vision Loss ◽  
Early Recognition ◽  
Antihypertensive Agents ◽  
Reversible Posterior Leukoencephalopathy Syndrome ◽  
Neurological Damage ◽  
Reversible Posterior Leukoencephalopathy ◽  
Posterior Leukoencephalopathy

A 64-year-old Japanese man had started molecular-targeted therapy with sunitinib for lymph node metastasis 5 years after nephrectomy for left renal cell carcinoma (clear cell carcinoma, G2, pT2N0M0). He was transported to our emergency department because of generalized tonic-clonic seizure, vision loss, and impaired consciousness with acute hypertension after 8 cycles of treatment (2 years after the initiation of sunitinib therapy, including a drug withdrawal period for one year). MRI of the brain (FLAIR images) showed multiple high-intensity lesions in the white matter of the occipital and cerebellar lobes, dorsal brain stem, and left thalamus. Reversible posterior leukoencephalopathy syndrome caused by sunitinib was suspected. In addition to the immediate discontinuation of sunitinib therapy, the administration of antihypertensive agents and anticonvulsants improved the clinical symptoms without neurological damage. Physicians should be aware that sunitinib causes reversible posterior leukoencephalopathy syndrome. The early recognition of reversible posterior leukoencephalopathy syndrome is critical to avoid irreversible neurological damage.

1253: Different Survival in PT3A Renal Cell Carcinoma with Sinus Fat Invasion or Perinephric Fat Invasion

2007 ◽  
Vol 177 (4S) ◽  
pp. 413-413
Author(s):  
Marco Roscigno ◽  
Roberto Bertini ◽  
Cesare Cozzarini ◽  
Alessandra Pasta ◽  
Mattia Sangalli ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Perinephric Fat

1252: Relative Survival Following Treatment for Renal Cell Carcinoma (RCC)- A S.E.E.R. Analysis: Is Age Important?

2007 ◽  
Vol 177 (4S) ◽  
pp. 413-413
Author(s):  
Yu-Ning Wong ◽  
Brian L. Egleston ◽  
Ismail R. Saad ◽  
Robert G. Uzzo
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Relative Survival

920: Pediatric Renal Cell Carcinoma: An Aggressive Tumor with Biologic Features Distinct From Its Adult Counterpart

2007 ◽  
Vol 177 (4S) ◽  
pp. 305-305
Author(s):  
Richard A. Ashley ◽  
Jonathan C. Routh ◽  
Sameer A. Siddiqui ◽  
Brant A. Inman ◽  
Thomas J. Sebo ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Pediatric Renal Cell Carcinoma ◽  
Aggressive Tumor

915: Prognosis and Survival of Synchronous Bilateral Renal Cell Carcinoma: A Multicenter Experience

2007 ◽  
Vol 177 (4S) ◽  
pp. 303-304 ◽  
Author(s):  
Tobias Klatte ◽  
Heiko Wunderlich ◽  
Jean-Jacques Patard ◽  
Mark D. Kleid ◽  
John S. Lam ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Bilateral Renal Cell Carcinoma

908: Preoperative C-Reactive Protein Elevation as a Predictor of Localized Renal Cell Carcinoma

2007 ◽  
Vol 177 (4S) ◽  
pp. 301-301
Author(s):  
Yasumasa Iimura ◽  
Kazutaka Saito ◽  
Minato Yokoyama ◽  
Hitoshi Masuda ◽  
Tsuyoshi Kobayashi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Localized Renal Cell Carcinoma
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