scholarly journals Role of inflammation in oral carcinogenesis (Part I): Histological grading of malignancy using a binary system

2011 ◽  
Vol 2 (6) ◽  
pp. 1225-1231 ◽  
Author(s):  
MARTA RABELLO PIVA ◽  
LÉLIA BATISTA DE SOUZA ◽  
PAULO RICARDO SAQUETE MARTINS-FILHO ◽  
ROSILENE CALAZANS SOARES ◽  
THIAGO DE SANTANA SANTOS ◽  
...  
Keyword(s):  
Binary System ◽  
Histological Grading ◽  
Oral Carcinogenesis

scholarly journals Role of Oral Microbiome Signatures in Diagnosis and Prognosis of Oral Cancer

2019 ◽  
Vol 18 ◽  
pp. 153303381986735 ◽  
Author(s):  
Indranil Chattopadhyay ◽  
Mukesh Verma ◽  
Madhusmita Panda
Keyword(s):  
Oral Cancer ◽  
Epithelial Cells ◽  
Oral Cavity ◽  
Bacterial Species ◽  
Treatment Strategies ◽  
Genetic Alterations ◽  
Oral Microbiome ◽  
Oral Carcinogenesis ◽  
Early Diagnostic

Despite advancement in cancer treatment, oral cancer has a poor prognosis and is often detected at late stage. To overcome these challenges, investigators should search for early diagnostic and prognostic biomarkers. More than 700 bacterial species reside in the oral cavity. The oral microbiome population varies by saliva and different habitats of oral cavity. Tobacco, alcohol, and betel nut, which are causative factors of oral cancer, may alter the oral microbiome composition. Both pathogenic and commensal strains of bacteria have significantly contributed to oral cancer. Numerous bacterial species in the oral cavity are involved in chronic inflammation that lead to development of oral carcinogenesis. Bacterial products and its metabolic by-products may induce permanent genetic alterations in epithelial cells of the host that drive proliferation and/or survival of epithelial cells. Porphyromonas gingivalis and Fusobacterium nucleatum induce production of inflammatory cytokines, cell proliferation, and inhibition of apoptosis, cellular invasion, and migration thorough host cell genomic alterations. Recent advancement in metagenomic technologies may be useful in identifying oral cancer–related microbiome, their genomes, virulence properties, and their interaction with host immunity. It is very important to address which bacterial species is responsible for driving oral carcinogenesis. Alteration in the oral commensal microbial communities have potential application as a diagnostic tool to predict oral squamous cell carcinoma. Clinicians should be aware that the protective properties of the resident microflora are beneficial to define treatment strategies. To develop highly precise and effective therapeutic approaches, identification of specific oral microbiomes may be required. In this review, we narrate the role of microbiome in the progression of oral cancer and its role as an early diagnostic and prognostic biomarker for oral cancer.

scholarly journals Role of bacteria in oral carcinogenesis

2012 ◽  
Vol 01 (02) ◽  
pp. 78-83 ◽  
Author(s):  
R Rajeev ◽  
Kanaram Choudhary ◽  
Swagatika Panda ◽  
Neha Gandhi
Keyword(s):  
Metabolic Pathways ◽  
Bacterial Species ◽  
Cancer Therapeutics ◽  
Microbial Populations ◽  
Genetic Mutations ◽  
Oral Carcinogenesis ◽  
Common Cancer ◽  
Indian Men ◽  
Oral Microorganisms

AbstractOral cancer is the most common cancer diagnosed in Indian men and is the leading cause of cancer deaths. It is considered as a multistep and multifactorial disease. Besides accumulation of genetic mutations, numerous other carcinogens are involved. In this category, viral and chemical carcinogens are well studied and documented. However, in the oral cavity, the role of microbiota in carcinogenesis is not known. Microbial populations on mouth mucosa differ between healthy and malignant sites, and certain oral bacterial species have been linked with malignancies, but the evidence is still weak in this respect. Nevertheless, oral microorganisms inevitably up-regulate cytokines and other inflammatory mediators that affect the complex metabolic pathways, and may thus be involved in carcinogenesis. Poor oral health associates statistically with prevalence of many types of cancer such as pancreatic and gastrointestinal cancer. This review presents possible carcinogenesis pathway involved in bacterial carcinogenesis, commonly implicated bacteria in oral carcinogenesis, and their role in cancer therapeutics as well.

The Role of Temperature on Hydration of Binary System of Metakaolin/Portland Cement

2016 ◽  
Vol 851 ◽  
pp. 51-56 ◽  
Author(s):  
Martin Boháč ◽  
Radoslav Novotný ◽  
Jakub Tkacz ◽  
Miroslava Hajdúchová ◽  
Martin Palou ◽  
...  
Keyword(s):  
Binary System ◽  
Portland Cement ◽  
Isothermal Calorimetry ◽  
Chemical Characterization ◽  
Exothermic Peak ◽  
Early Hydration ◽  
Different Temperatures ◽  
C 50

The role of temperature of metakaolin/Portland cement binary system was studied by isothermal calorimetry. Sample with 50 % of metakaolin replacement were monitored at 30 °C, 40 °C, 50 °C and 60 °C. Structural and chemical characterization of hardened pastes was obtained by scanning electron and Raman microscopy. Paper deals with kinetics of main exothermal reactions during early hydration of the system. Activation energies were calculated for processes related to each exothermic peak. The nature of hydration products at different temperatures was revealed by microstructural studies.

scholarly journals Role of SIRT3 in the regulation of redox balance during oral carcinogenesis

2013 ◽  
Vol 12 (1) ◽  
pp. 68 ◽  
Author(s):  
I-Chieh Chen ◽  
Wei-Fan Chiang ◽  
Shyun-Yeu Liu ◽  
Pei-Fen Chen ◽  
Hung-Che Chiang
Keyword(s):  
Redox Balance ◽  
Oral Carcinogenesis

Role of Stoichiometry on Ordering in Ni-Cr Alloys

2015 ◽  
Vol 1809 ◽  
pp. 7-12 ◽  
Author(s):  
Fei Teng ◽  
Julie D. Tucker
Keyword(s):  
Mechanical Property ◽  
Phase Transformation ◽  
Binary System ◽  
Nuclear Power ◽  
Experimental Methods ◽  
X Ray Diffraction ◽  
Control Rod ◽  
X Ray ◽  
Reactor Pressure

ABSTRACTMechanical property degradation due to an ordering phase transformation is a concern for alloys based on the Ni-Cr binary system (e.g., 690, 625), particularly in nuclear power applications, such as stream generator tubing, reactor pressure vessel and head control rod drive mechanism penetrations, where component lifetimes can exceed 40 years. In the present research, the disorder-order phase transformation has been studied in Ni-Cr model alloys with varying stoichiometry by experimental methods. In this paper, the effect of composition on ordering is characterized via X-ray diffraction.

Strong Piezoelectricity in (1 – x)(K0.4Na0.6)(Nb0.96Sb0.04)O3-xBi0.5K0.5Zr1–ySnyO3 Lead-Free Binary System: Identification and Role of Multiphase Coexistence

2015 ◽  
Vol 7 (10) ◽  
pp. 5927-5937 ◽  
Author(s):  
Ting Zheng ◽  
Jiagang Wu ◽  
Dingquan Xiao ◽  
Jianguo Zhu ◽  
Xiangjian Wang ◽  
...  
Keyword(s):  
System Identification ◽  
Binary System ◽  
Lead Free

scholarly journals Dramatografia

2017 ◽  
pp. 195-226
Author(s):  
Anna Krajewska
Keyword(s):  
Binary System

The article presents the concept of dramatography as being created by “writing drama”. The author treats drama as a fluid concept, historically variable, non-binary compared to theatre, establishing performative relations interwoven with other arts. Dramatography is a response to limitations resulting from the use of the concepts of adaptation, interpretation and intersemiotic translation in the former binary system in drama and theatre. Referring to Hans Ulrich Gumbrecht’s concept of “producing presence”, the author shows the role of manifesting oneself as a counterweight to meaning in the process through which dramatography emerges.

scholarly journals Predictive Role of p53 Protein as a Single Marker or Associated to Ki67 Antigen in Oral Carcinogenesis

2007 ◽  
Vol 2 (1) ◽  
pp. 24-29 ◽  
Author(s):  
L. Montebugnoli ◽  
L. Felicetti ◽  
D. B. Gissi ◽  
F. Cervellati ◽  
D. Servidio ◽  
...  
Keyword(s):  
P53 Protein ◽  
Oral Carcinogenesis ◽  
Ki67 Antigen ◽  
Single Marker ◽  
Predictive Role
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