Tadalafil reduces visceral adipose tissue accumulation by promoting preadipocytes differentiation towards a metabolically healthy phenotype: Studies in rabbits

2016 ◽  
Vol 424 ◽  
pp. 50-70 ◽  
Author(s):  
Elena Maneschi ◽  
Ilaria Cellai ◽  
Antonio Aversa ◽  
Tommaso Mello ◽  
Sandra Filippi ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Tissue Accumulation ◽  
Metabolically Healthy ◽  
Visceral Adipose

Abstract 17843: Visceral Adipose Tissue Secretion of Adiponectin Decreases with Increased Body Mass Index

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Lenore R Rengel ◽  
Brittaney Obi ◽  
Jon Gould ◽  
Matthew Goldblatt ◽  
Andrew Kastenmeier ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Metabolic Health ◽  
Metabolically Healthy Obese ◽  
Obese Subjects ◽  
Healthy Obese ◽  
Metabolically Healthy ◽  
Visceral Adipose ◽  
Subcutaneous Adipose

Introduction: Peripheral adiposity is associated with better metabolic health and higher plasma adiponectin (ADPN) levels. Since ADPN is secreted mainly by adipose tissue (AT), it is intriguing that higher visceral adipose tissue (VAT) is associated with lower ADPN levels and poor metabolic health. Hypothesis: We hypothesized that various AT depots differ in their ability to secrete ADPN. Methods: Paired AT samples (VAT and subcutaneous adipose tissue (SAT)) were collected from 19 subjects (10 women, 15 obese) undergoing elective abdominal surgery. The samples were cultured and the supernatant was collected after 24 hours. ADPN levels released into the supernatant from VAT and SAT were measured using multiplex methods. Subjects were defined as obese or non-obese (NO) based on BMI > or ≤ 30kg/m2 respectively. Obese subjects were further classified as metabolically unhealthy obese (MUO) or metabolically healthy obese (MHO) based on presence or absence of type 2 diabetes mellitus, hypertension, or cardiovascular disease at the time of surgery. Results: Mean ADPN secretion levels from SAT and VAT were similar in NO subjects (17.3 ± 3.4 vs. 9.8 ± 13.0 ng/mL/mg, p=0.5) whereas the mean ADPN secretion was lower from VAT among obese subjects (15.9 ± 0.8 vs. 4.5 ± 0.2 ng/mL/mg, p=0.0002). ADPN secretion decreased from VAT (r=-0.16) and increased from SAT (r=0.33) with increased BMI (Fig.1). When MHO and MUO were compared, ADPN secretion from VAT in MHO was reduced only slightly (16.1 ± 8.2 vs. 4.0 ± 2.0 ng/mL/mg, p=0.07) whereas ADPN secretion was significantly reduced in MUO (15.9 ± 5.3 vs. 4.7 ± 4.6 ng/mL/mg, p=0.003). Conclusions: Reduced ADPN secretion from VAT in subjects with increasing BMI may explain lower circulating ADPN levels in obese individuals. Higher ADPN production from SAT and the relatively preserved secretion of ADPN from VAT may explain metabolic health in some obese individuals. Futures studies will help identify factors that control ADPN secretion from AT.

Effects of Growth Hormone on Abnormal Visceral Adipose Tissue Accumulation and Dyslipidemia in HIV-Infected Patients

2004 ◽  
Vol 35 (3) ◽  
pp. 239-252 ◽  
Author(s):  
Donald P. Kotler ◽  
Norma Muurahainen ◽  
Carl Grunfeld ◽  
Christine Wanke ◽  
Melanie Thompson ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Tissue Accumulation ◽  
Visceral Adipose

Visceral adipose tissue accumulation, secretory phospholipase A2-IIA and atherogenecity of LDL

2006 ◽  
Vol 30 (11) ◽  
pp. 1615-1622 ◽  
Author(s):  
M-E Paradis ◽  
M-O Hogue ◽  
J-F Mauger ◽  
C Couillard ◽  
P Couture ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Phospholipase A2 ◽  
Visceral Adipose Tissue ◽  
Secretory Phospholipase A2 ◽  
Tissue Accumulation ◽  
Secretory Phospholipase ◽  
Visceral Adipose

Human adipose tissue accumulation is connected with pro-inflammatory changes in subcutaneous rather than visceral adipose tissue

2017 ◽  
Vol 263 ◽  
pp. e72
Author(s):  
Ivana Kralova Lesna ◽  
Anna Kralova ◽  
Sona Cejkova ◽  
Jiri Fronek ◽  
Marek Petras ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Human Adipose Tissue ◽  
Tissue Accumulation ◽  
Visceral Adipose ◽  
Inflammatory Changes

Visceral Adipose Tissue Accumulation and Residual Cardiovascular Risk

2018 ◽  
Vol 20 (9) ◽  
Author(s):  
Thierry H. Le Jemtel ◽  
Rohan Samson ◽  
Gregory Milligan ◽  
Abhishek Jaiswal ◽  
Suzanne Oparil
Keyword(s):  
Adipose Tissue ◽  
Cardiovascular Risk ◽  
Visceral Adipose Tissue ◽  
Residual Cardiovascular Risk ◽  
Tissue Accumulation ◽  
Visceral Adipose

Associations between the fatty acid content of triglyceride, visceral adipose tissue accumulation, and components of the insulin resistance syndrome

Metabolism ◽  
2004 ◽  
Vol 53 (3) ◽  
pp. 310-317 ◽  
Author(s):  
André J. Tremblay ◽  
Jean-Pierre Després ◽  
Marie-Ève Piché ◽  
André Nadeau ◽  
Jean Bergeron ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Visceral Adipose Tissue ◽  
Acid Content ◽  
Fatty Acid Content ◽  
Insulin Resistance Syndrome ◽  
Tissue Accumulation ◽  
Visceral Adipose
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