scholarly journals Effects of embryonic exposure to polychlorinated biphenyls on zebrafish skeletal development

2012 ◽  
Author(s):  
Yue Lou
Keyword(s):  
Polychlorinated Biphenyls ◽  
Skeletal Development ◽  
Embryonic Exposure

Effects of embryonic exposure to polychlorinated biphenyls on zebrafish (Danio rerio) retinal development

2011 ◽  
Vol 32 (3) ◽  
pp. 186-193 ◽  
Author(s):  
Yan-Ping Wang ◽  
Qin Hong ◽  
Da-ni Qin ◽  
Chun-Zhao Kou ◽  
Chun-Mei Zhang ◽  
...  
Keyword(s):  
Polychlorinated Biphenyls ◽  
Danio Rerio ◽  
Retinal Development ◽  
Embryonic Exposure

scholarly journals Effects of embryonic exposure to polychlorinated biphenyls (PCBs) on anxiety-related behaviors in larval zebrafish

2016 ◽  
Vol 53 ◽  
pp. 93-101 ◽  
Author(s):  
Sarah T. Gonzalez ◽  
Dylan Remick ◽  
Robbert Creton ◽  
Ruth M. Colwill
Keyword(s):  
Polychlorinated Biphenyls ◽  
Larval Zebrafish ◽  
Embryonic Exposure

Pesticide and non-dioxin-like polychlorinated biphenyls (NDL-PCBs) residues in foodstuffs from Ismailia city, Egypt

2008 ◽  
pp. 1-9 ◽  
Author(s):  
N. Loutfy ◽  
M. Fuerhacker ◽  
C. Lesueur ◽  
M. Gartner ◽  
M. Tawfic Ahmed ◽  
...  
Keyword(s):  
Polychlorinated Biphenyls

The effect of mTORC1 on postnatal skeletal development

2013 ◽  
Author(s):  
Mary Matthews ◽  
Andrew Zannettino ◽  
Stephen Fitter ◽  
Sally Martin
Keyword(s):  
Skeletal Development

Maternal vitamin D depletion disrupts neonatal skeletal development in mice

2015 ◽  
Author(s):  
Harriet Buckley ◽  
Stephanie Borg ◽  
Kirsty Nicholson ◽  
Mark Kinch ◽  
David Hughes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Skeletal Development ◽  
Maternal Vitamin ◽  
Vitamin D Depletion

Fatty Liver and Impaired Hepatic Metabolism Alters the Congener-Specific Distribution of Polychlorinated Biphenyls (PCBs) in Mice with a Liver-Specific Deletion of Cytochrome P450 Reductase

2020 ◽  
Author(s):  
Xueshu Li ◽  
Chun-Yun Zhang ◽  
Hans-Joachim Lehmler
Keyword(s):  
Cytochrome P450 ◽  
Polychlorinated Biphenyls ◽  
Fatty Liver ◽  
Partition Coefficients ◽  
Hepatic Metabolism ◽  
Gas Chromatography Mass Spectrometry ◽  
Cytochrome P450 Reductase ◽  
P450 Reductase ◽  
Specific Distribution ◽  
Specific Deletion

Polychlorinated biphenyls (PCBs) are persistent organic pollutants that are linked to adverse health outcomes. PCB tissue levels are determinants of PCB toxicity; however, it is unclear how factors, such as an altered metabolism and/or a fatty liver, affect PCB distribution in vivo. We determined the congener-specific disposition of PCBs in mice with a liver specific deletion of cytochrome P450 reductase (KO), a model of fatty liver with impaired hepatic metabolism, and wildtype (WT) mice. Male and female KO and WT mice were exposed orally to Aroclor 1254, a technical PCB mixture. PCBs were quantified in adipose, blood, brain and liver tissues by gas chromatography-mass spectrometry. PCB profiles and levels in tissues were genotype and sex dependent. PCB levels were higher in the liver from KO compared to WT mice. PCB profiles showed clear differences between tissues from the same exposure group. While experimental tissue : blood partition coefficients in KO and WT mice did not follow the trends predicted using a composition-based model, the agreement between experimental and calculated partition coefficients was still reasonable. Thus, a fatty liver and/or an impaired hepatic metabolism alter the distribution of PCBs in mice and the magnitude of the partitioning of PCBs from blood into tissues can be approximated using composition-based models.<br>

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