scholarly journals Protective effect of myricetin in dextran sulphate sodium-induced murine ulcerative colitis

2012 ◽  
Vol 7 (2) ◽  
pp. 565-570 ◽  
Author(s):  
JING ZHAO ◽  
TIE HONG ◽  
MAN DONG ◽  
YIXIAO MENG ◽  
JIAYE MU
Keyword(s):  
Ulcerative Colitis ◽  
Protective Effect ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium

scholarly journals Protective Effect ofCalculus Bovis Sativuson Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Xiping Li ◽  
Yanjiao Xu ◽  
Chengliang Zhang ◽  
Li Deng ◽  
Mujun Chang ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Protective Effect ◽  
Activity Index ◽  
Disease Activity Index ◽  
Inflammatory Cells ◽  
Dextran Sulphate ◽  
Colon Tissue ◽  
Sod Activity ◽  
Dextran Sulphate Sodium ◽  
Anti Inflammatory

Calculus Bovis Sativus(CBS) is a commonly used traditional Chinese medicine, which has been reported to exhibit antispasmodic, fever-reducing, anti-inflammatory, and gallbladder-repairing effects. The present study aims to investigate the protective effect of CBS on dextran sulphate sodium- (DSS-) induced ulcerative colitis (UC) in mice. C57BL/6 male mice were exposed to 5% DSS in drinking water. CBS was given orally at 50 and 150 mg/kg once per day for 7 days. Body weight, disease activity index (DAI), colon length, colonic myeloperoxidase (MPO) activity, superoxide dismutase (SOD) activity, and malondialdehyde (MDA) and nitric oxide (NO) levels were measured. Administration of CBS significantly reserved these changes, decreased the MPO activity and MDA and NO level, and increased the SOD activity in the colon tissue. Histological observation suggested that CBS alleviated edema, mucosal damage, and inflammatory cells infiltration induced by DSS in the colon. Moreover, CBS significantly downregulated the mRNA expression of tumor necrosis factor-α(TNF-α), interleukin- (IL-) 1βand IL-6 in the colon tissue. Our data suggested that CBS exerted protective effect on DSS-induced UC partially through the antioxidant and anti-inflammatory activities.

Stevioside, a diterpenoid glycoside, shows anti-inflammatory property against Dextran Sulphate Sodium-induced ulcerative colitis in mice

2019 ◽  
Vol 855 ◽  
pp. 192-201 ◽  
Author(s):  
Sateesh Alavala ◽  
Rajendra Sangaraju ◽  
Nasiruddin Nalban ◽  
Bidya Dhar Sahu ◽  
Mahesh Kumar Jerald ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium ◽  
Anti Inflammatory

scholarly journals Flaxseed oil alleviates dextran sulphate sodium-induced ulcerative colitis in rats

2020 ◽  
Vol 64 ◽  
pp. 103602 ◽  
Author(s):  
Qian Zhou ◽  
Lei Ma ◽  
Wenyang Zhao ◽  
Wen Zhao ◽  
Xue Han ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Flaxseed Oil ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium

Induction of ulcerative colitis in mice influences the course of infection with the nematode Trichuris muris

2014 ◽  
Vol 89 (5) ◽  
pp. 593-600 ◽  
Author(s):  
M.C. Vegas-Sánchez ◽  
E. Rollán-Landeras ◽  
J.J. García-Rodríguez ◽  
F. Bolás-Fernández
Keyword(s):  
Ulcerative Colitis ◽  
Concurrent Infection ◽  
Dextran Sulphate ◽  
Oral Gavage ◽  
Acute Colitis ◽  
Trichuris Muris ◽  
Dextran Sulphate Sodium ◽  
Beneficial Effects ◽  
Chemically Induced ◽  
Inflammatory Bowel

AbstractThe aim of this study was to assess the effect of infection with the nematode whipworm Trichuris muris on the course of chemically induced acute ulcerative colitis in CBA/J mice, a strain proven to be highly resistant to infection with T. muris. Each mouse was infected with 50 embryonated eggs of T. muris by oral gavage. Acute colitis was triggered by administering 4% dextran sulphate sodium (DSS) in the drinking water for nine consecutive days at different times after infection. Concurrent infection and DSS administration exacerbate the severity of the colitis while favouring the permanence of parasites in the intestine. The induction of ulcerative colitis from days 54 to 62 post-infection (p.i.), when all worms had been expelled, ameliorated the course of the inflammatory disease. When ulcerative colitis was triggered earlier on, from days 27 to 35 p.i., the beneficial effects on inflammatory events were clearly shown with signs of mucosal epithelization and regeneration as early as day 1 after DSS administration. Previous infections by T. muris therefore accelerate recovery from subsequently induced inflammatory bowel disease and such an effect assists the nematode to persist in the intestinal niche.

scholarly journals Maggot protein ameliorates dextran sulphate sodium-induced ulcerative colitis in mice

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Rong Wang ◽  
Lei Wang ◽  
Yongzheng Luo ◽  
Daojuan Wang ◽  
Ronghui Du ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Activity Index ◽  
Water Model ◽  
Inflammatory Factors ◽  
Control Group ◽  
Sterile Water ◽  
Dextran Sulphate ◽  
Model Group ◽  
Dextran Sulphate Sodium ◽  
Body Weights

Ulcerative colitis (UC) is a common chronic remitting disease but without satisfactory treatment. Maggots are known as a traditional Chinese medicine named as ‘wu gu chong’. The aim of the present study was to investigate the therapeutic effect of the maggot protein on dextran sulphate sodium (DSS)-induced colitis in C57BL/6 mice. In the present study, female C57BL/6 mice were given sterile water containing 3% DSS to establish the model of UC. Mice were randomly divided into five groups: control group (sterile water), model group (DSS), treatment group (DSS + maggot protein), mesalazine group (DSS + mesalazine), and maggot protein group (sterile water + maggot protein). The mental state, defecate traits, and changes in body weights were recorded daily. The disease activity index (DAI) as a disease severity criterion was calculated based on body weights and stool consistency and bleeding. All the mice were killed on the 12th day. Colon length, colon histological changes, and other inflammatory factors were analyzed and evaluated. The results showed that colitis models of mice were established successfully. Administration of maggot protein markedly suppressed the severity of UC compared with the DSS model group. Furthermore, maggot protein potently ameliorated DSS-induced weight loss, colon shortening, and colon histological injury. Moreover, the maggot protein exerted anti-inflammatory effects via inhibition of the activation of the nuclear factor κB (NFκB) signaling pathway. In summary, treatment by maggot protein was able to improve not only the symptoms of colitis, but also the microscopic inflammation in mice with DSS-induced colitis. The present study may have implications for developing an effective therapeutic strategy for inflammatory bowel diseases (IBDs).

Sign in / Sign up

Export Citation Format

Share Document