Role of miR-150-targeting c-Myb in colonic epithelial disruption during dextran sulphate sodium-induced murine experimental colitis and human ulcerative colitis

2011 ◽  
Vol 225 (4) ◽  
pp. 544-553 ◽  
Author(s):  
Zhen Bian ◽  
Limin Li ◽  
Jinglong Cui ◽  
Hongjie Zhang ◽  
Yuan Liu ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Experimental Colitis ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium ◽  
Epithelial Disruption

scholarly journals Nigella A ameliorates experimental colitis via interacting with gut microbiota on dextran sulphate sodium (DSS)-induced C57BL/6 mice

2020 ◽  
Author(s):  
XingJiang Hu ◽  
Nana Xu ◽  
Xi Yang ◽  
Xi Hu ◽  
Yunliang Zheng ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Chinese Medicine ◽  
Therapeutic Effect ◽  
Antioxidant Activities ◽  
Intestinal Flora ◽  
Signs And Symptoms ◽  
Experimental Colitis ◽  
Dextran Sulphate ◽  
Microbial Composition ◽  
Dextran Sulphate Sodium

Abstract Nigella A, also named Sieboldianoside A, has been extracted from many kinds of Traditional Chinese Medicine (TCM), such as Nigella glandulifera, Stauntonia chinensis DC., and the leaves of Acanthopanax sieboldianus. Nigella A exhibited potential analgesic, anti-inflammatory, anti-tumor, and antioxidant activities. However, whether Nigella A could treat ulcerative colitis (UC) is still unknown. As saponins always be regarded as the kinds of ingredients that could regulate immunity and intestinal flora. This research aimed to investigate the therapeutic effect of Nigella A on UC and explore its effect on intestinal flora. We noted that Nigella A and SASP could significantly improve the signs and symptoms, alleviate colonic pathological injury in DSS-induced mice. The changing of many specific bacterial genus such as Lactobacillus, Porphyromonadaceae, Bacteroides and Escherichia might closely related to the recovery of intestinal inflammatory response. This study initially confirmed the therapeutic effect of Nigella A and SASP on DSS-induced colitis by improving the diversity of intestinal microbial composition. Nigella A has the potential to be developed for the treatment of UC and other disorders related to the imbalance of intestinal flora.

Protective role of liriodendrin in mice with dextran sulphate sodium-induced ulcerative colitis

2017 ◽  
Vol 52 ◽  
pp. 203-210 ◽  
Author(s):  
Zhen Zhang ◽  
Lei Yang ◽  
Botao Wang ◽  
Lanqiu Zhang ◽  
Qi Zhang ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Protective Role ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium

Stevioside, a diterpenoid glycoside, shows anti-inflammatory property against Dextran Sulphate Sodium-induced ulcerative colitis in mice

2019 ◽  
Vol 855 ◽  
pp. 192-201 ◽  
Author(s):  
Sateesh Alavala ◽  
Rajendra Sangaraju ◽  
Nasiruddin Nalban ◽  
Bidya Dhar Sahu ◽  
Mahesh Kumar Jerald ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium ◽  
Anti Inflammatory

scholarly journals The role of central and peripheral D2R receptors in the mechanism of colonic vascular permeability during experimental colitis in rats

2017 ◽  
Vol 22 (1) ◽  
pp. 39-43
Author(s):  
A. Prysiazhniuk ◽  
T. Dovbynchuk ◽  
B. Kopiyak ◽  
G. Tolstanova
Keyword(s):  
Ulcerative Colitis ◽  
Vascular Permeability ◽  
Experimental Colitis ◽  
Inbred Rats ◽  
Simultaneous Activation ◽  
Colitis Ulcerative ◽  
Joint Injections ◽  
Positive Effect ◽  
Experimental Ulcerative Colitis

We investigated the involvement of central and peripheral D2 dopaminergic receptors in the mechanism of vascular permeability in rat's colon during experimental ulcerative colitis. Ulcerative colitis was induced in male white inbred rats by 6 % iodoacetamide enema. For the investigation of central and peripheral D2R, separate and joint injections of D2R antagonist domperidone (2 mg/100 g, per os) and D2R agonist quinpirole (1 mg/100 g, per os) were applied. Central D2R were destroyed by neurotoxin injection – 6OHDA. Colonic vascular permeability was measured by colonic extravasation of 1,5 % Evans blue. It was observed that blockade of peripheral D2R decreased colonic vascular permeability, while simultaneous activation of central D2R and inhibition of peripheral D2R have additive positive effect in prevention of increased colonic vascular permeability during experimental colitis.

scholarly journals Flaxseed oil alleviates dextran sulphate sodium-induced ulcerative colitis in rats

2020 ◽  
Vol 64 ◽  
pp. 103602 ◽  
Author(s):  
Qian Zhou ◽  
Lei Ma ◽  
Wenyang Zhao ◽  
Wen Zhao ◽  
Xue Han ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Flaxseed Oil ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium

scholarly journals Induction of experimental colitis by dextran sulphate sodium in a piglet model of irritable bowel syndrome

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Dale Lackeyram ◽  
Connie Kim ◽  
Denise Young ◽  
Tania Archbold ◽  
Chengbo Yang ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Experimental Colitis ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium ◽  
Irritable Bowel
Sign in / Sign up

Export Citation Format

Share Document