scholarly journals Tumor budding is a significant indicator of a poor prognosis in lung squamous cell carcinoma patients

2012 ◽  
Vol 6 (5) ◽  
pp. 937-943 ◽  
Author(s):  
RYOTA MASUDA ◽  
HIROSHI KIJIMA ◽  
NAOKO IMAMURA ◽  
NAOHIRO ARUGA ◽  
YUSUKE NAKAMURA ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Lung Squamous Cell Carcinoma ◽  
Tumor Budding

scholarly journals Pyruvate Kinase M2 is a marker of poor prognosis in lung adenocarcinoma but not lung squamous cell carcinoma

2020 ◽  
Vol 9 (5) ◽  
pp. 3293-3302
Author(s):  
Junxia Zhang ◽  
Chengjuan Zhang ◽  
Xianghua Liu ◽  
Ning Sun ◽  
Caili Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lung Adenocarcinoma ◽  
Cell Carcinoma ◽  
Pyruvate Kinase ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Lung Squamous Cell Carcinoma ◽  
Pyruvate Kinase M2

scholarly journals STXBP4 Drives Tumor Growth and Is Associated with Poor Prognosis through PDGF Receptor Signaling in Lung Squamous Cell Carcinoma

2017 ◽  
Vol 23 (13) ◽  
pp. 3442-3452 ◽  
Author(s):  
Yukihiro Otaka ◽  
Susumu Rokudai ◽  
Kyoichi Kaira ◽  
Michiru Fujieda ◽  
Ikuko Horikoshi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Growth ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Lung Squamous Cell Carcinoma ◽  
Pdgf Receptor ◽  
Receptor Signaling

scholarly journals MA18.02 S100A10 Upregulation Associates with Poor Prognosis in Lung Squamous Cell Carcinoma

2019 ◽  
Vol 14 (10) ◽  
pp. S321-S322
Author(s):  
K. Sato ◽  
Y. Saiki ◽  
K. Arai ◽  
K. Ishizawa ◽  
S. Fukushige ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Lung Squamous Cell Carcinoma

Increased expression of connexin 26 in the invasive component of lung squamous cell carcinoma: Significant correlation with poor prognosis

2006 ◽  
Vol 234 (2) ◽  
pp. 239-248 ◽  
Author(s):  
Akihiko Ito ◽  
Yu-ichiro Koma ◽  
Kazuya Uchino ◽  
Tomoyo Okada ◽  
Chiho Ohbayashi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Lung Squamous Cell Carcinoma ◽  
Connexin 26 ◽  
Invasive Component

scholarly journals Vasohibin 2 Promotes Lymphangiogenesis of Lung Squamous Cell Carcinoma Through Snail-dependent VEGF-D Signaling Pathway

2020 ◽  
Author(s):  
Pengpeng Liu ◽  
Rui Zhang ◽  
Lei Han ◽  
Xiao Zhang ◽  
Yingnan Ye ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Endothelial Cells ◽  
Tumor Growth ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymphatic Metastasis ◽  
Poor Prognosis ◽  
Lung Squamous Cell Carcinoma ◽  
Secondary Site

Abstract Backgroumd: Tumor metastasis is a process in which tumor cells enter the lymphatic vessels and blood vessels and then spread to the secondary site where they form secondary tumors. In vascular biology, angiogenesis and anti-angiogenesis therapy have been extensively studied, however, the molecular mechanisms involved in lymphangiogenesis and lymphatic metastasis remain unclear.Methods: We analyzed mRNA expression profiles of 937 primary lung squamous cell carcinoma (LUSC) samples from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases to screen the most differentially expressed genes related to the poor prognosis of LUSC patients and validated in an independent Chinese LUSC cohort. We focused on Vasohibin 2 (VASH2) and investigated its biological functions in LUSC proliferation, apoptosis, migration, invasion, as well as lymphangiogenesis by forced over-expressing VASH2 in LUSC cell line H520 in vitro. We also investigated the anti-tumor efficacy of VASH2 target treatment in LUSC xenograft-bearing mice models.Results: We identified 12 genes closely related to poor prognosis of LUSC patients, among which VASH2 was validated in an independent Chinese LUSC cohort and displayed high potential of lymphatic metastasis. VASH2 promoted the proliferation and invasion of LUSC cells both in vitro and vivo. Forced over-expression of VASH2 in LUSC cells promoted the amplification and tube-formation of human umbilical vein endothelial cells (HUVECs) and human lymphatic endothelial cells (HLECs) cells via up-regulating vascular endothelial growth factor-D (VEGF-D) production which could be reversed by Snail inhibition. Furthermore, blocking VASH2/VEGF-D signaling using specific antibodies dramatically inhibited tumor growth in mice by interfering proliferation of cancer cells and lymphangiogenesis in tumor tissues. Conclusion: In conclusion, VASH2 facilitated lymphangiogenesis and tumor growth in a Snail-dependent manner which might serve as a novel biomarker for early diagnosis and prognosis prediction, as well as a potential therapeutic target in LUSC.Statement of conflict of interest: The authors declare no potential conflicts of interest.

S100A10 upregulation associates with poor prognosis in lung squamous cell carcinoma

2018 ◽  
Vol 505 (2) ◽  
pp. 466-470 ◽  
Author(s):  
Kimiaki Sato ◽  
Yuriko Saiki ◽  
Kazumori Arai ◽  
Kota Ishizawa ◽  
Shinichi Fukushige ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Lung Squamous Cell Carcinoma
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