scholarly journals Therapeutic challenges of extrapulmonary dual organ system involvement in COVID‑19: A case report

2021 ◽  
Vol 1 (5) ◽  
Author(s):  
Karniza Khalid ◽  
Suhaila Wahab ◽  
Khaulah Azni
Keyword(s):  
Case Report ◽  
Organ System ◽  
System Involvement

A Fatal Case of Pyoderma Gangrenosum with Multiple Organ System Involvement: Unexpected Progression: Case Report

2015 ◽  
Vol 25 (2) ◽  
pp. 67-70
Author(s):  
Suzan D. PEKTAŞ ◽  
Neriman D. ALTINTAŞ ◽  
Seval İZDEŞ ◽  
Sibel YÜCEL ◽  
Hayriye T. DOĞAN
Keyword(s):  
Case Report ◽  
Pyoderma Gangrenosum ◽  
Fatal Case ◽  
Multiple Organ ◽  
Organ System ◽  
System Involvement ◽  
Multiple Organ System

Lyme Disease: Acute Focal Meningoencephalitis in a Child

PEDIATRICS ◽  
1988 ◽  
Vol 82 (6) ◽  
pp. 931-934
Author(s):  
HENRY M. FEDER ◽  
EDWIN L. ZALNERAITIS ◽  
LOUIS REIK
Keyword(s):  
Nervous System ◽  
Case Report ◽  
Lyme Disease ◽  
Signs And Symptoms ◽  
Brain Parenchyma ◽  
Tick Bite ◽  
System Involvement ◽  
History Of ◽  
Csf Pleocytosis ◽  
The Brain

Nervous system involvement in Lyme disease was originally described as meningitis, cranial neuritis, and radiculoneuritis,1-3 but Lyme disease can also involve the brain parenchyma. We describe a child whose first manifestation of Lyme disease was an acute, focal meningoencephalitis with signs and symptoms such as fever, headache, slurred speech, hemiparesis, seizure, and CSF pleocytosis. CASE REPORT A 7-year-old boy was hospitalized Aug 27, 1985, because of hemiparesis. Six weeks prior to admission he had vacationed at Old Lyme, CT. There was no history of rash or tick bite. He had been well until eight hours prior to admission when fever and headache developed.

Case report of a Rare Cause of Portal Hypertension

2021 ◽  
Vol 3 (6) ◽  
pp. 01-03
Author(s):  
Mra Aye
Keyword(s):  
Nervous System ◽  
Case Report ◽  
Portal Hypertension ◽  
Genetic Architecture ◽  
Developmental Disorder ◽  
Chromosome 7 ◽  
Morbidity And Mortality ◽  
Facial Features ◽  
System Involvement ◽  
William Syndrome

Williams or Williams-Beuren (WBS) is a developmental disorder with multisystemic manifestations. Chromosome 7 microdeletion underlying WBS occurs because of the unique genetic architecture in this region. Facial features change from subtle to dramatic. The extent of mental and development problems is variable. Cardiovascular, endocrine, and nervous system involvement mostly affect the morbidity and mortality. Although many systems are involved in this syndrome, portal hypertension and splenomegaly are scarcely reported. We report a case of William syndrome with moderate splenomegaly and portal hypertension.

Clinical Characteristics and Organ System Involvement in Sarcoidosis: Comparison of the University of Minnesota Cohort and Other Cohorts

2020 ◽  
Author(s):  
Hok Sreng ◽  
David M Perlman ◽  
Chetan Shenoy ◽  
Daniel J Steinberger ◽  
Rebecca J Cogswell ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
High Variability ◽  
Organ System ◽  
Assessment Instrument ◽  
Genomic Research ◽  
Unknown Etiology ◽  
University Of Minnesota ◽  
System Involvement ◽  
Tertiary Center ◽  
The University

Abstract Background: Sarcoidosis is a systemic granulomatous disease of unknown etiology. Clinical cohort studies of different populations are important to understand the high variability in clinical presentation and disease course of sarcoidosis. The aim of the study is to evaluate clinical characteristics, including organ involvement, pulmonary function tests, and laboratory parameters, in a sarcoidosis cohort at the University of Minnesota. We compare the organ system involvement of this cohort with other available cohorts. Methods: We conducted a retrospective data collection and analysis of 187 subjects with biopsy-proven sarcoidosis seen at a tertiary center. Organ system involvement was determined using the WASOG sarcoidosis organ assessment instrument. Clinical phenotype groups were classified using the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis criteria. Results: Mean subject age at diagnosis was 45.8 ± 12.4, with a higher proportion of males (55.1%), and a higher proportion of blacks (17.1%) compared to the racial distribution of Minnesota residents (5.95%). The majority (71.1%) of subjects required anti-inflammatory therapy for at least 1 month. Compared to the A Case Control Etiologic Study of Sarcoidosis cohort, there was a higher frequency of extra-thoracic lymph node (34.2% vs. 15.2%), eye (20.9% vs. 11.8%), liver (17.6% vs. 11.5%), spleen (20.9% vs. 6.7%), musculoskeletal (9.6% vs. 0.5%), and cardiac (10.7% vs. 2.3%) involvement in our cohort. A multisystem disease with at least five different organs involved was identified in 13.4% of subjects. A restrictive physiological pattern was observed in 21.6% of subjects, followed by an obstructive pattern in 17.3% and mixed obstructive and restrictive pattern in 2.2%. Almost half (49.2%) were Scadding stages II/III. Commonly employed disease activity markers, including soluble interleukin-2 receptor and angiotensin-converting enzyme, did not differ between treated and untreated groups. Conclusions: This cohort features a relatively high frequency of high-risk sarcoidosis phenotypes including cardiac and multiorgan disease. Commonly-utilized serum biomarkers do not identify subpopulations that require or do better with treatment. Findings from this study present further the high-variability nature of sarcoidosis and the need for a more reliable biomarker to predict and measure disease severity and outcomes for better clinical management for sarcoidosis patients.

scholarly journals Animal Virus Ecology and Evolution Are Shaped by the Virus Host-Body Infiltration and Colonization Pattern

Pathogens ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 72
Author(s):  
Jan Slingenbergh
Keyword(s):  
Virus Transmission ◽  
Mass Rearing ◽  
Virus Genome ◽  
Organ System ◽  
Emerging Viruses ◽  
Cell Infection ◽  
Host Environment ◽  
Animal Virus ◽  
Host Tropism ◽  
System Involvement

The current classification of animal viruses is largely based on the virus molecular world. Less attention is given to why and how virus fitness results from the success of virus transmission. Virus transmission reflects the infection-shedding-transmission dynamics, and with it, the organ system involvement and other, macroscopic dimensions of the host environment. This study describes the transmission ecology of the world main livestock viruses, 36 in total, a mix of RNA, DNA and retroviruses. Following an iterative process, the viruses are virtually ranked in an outer- to inner-body fashion, by organ system, on ecological grounds. Also portrayed are the shifts in virus host tropism and virus genome. The synthesis of the findings reveals a predictive virus evolution framework, based on the outer- to inner-body changes in the interplay of host environment-transmission modes-organ system involvement-host cell infection cycle-virus genome. Outer-body viruses opportunistically respond to the variation in the external environment. For example, respiratory and enteric viruses tend to be associated with poultry and pig mass rearing. Ruminant and equine viruses tend to be more deep-rooted and host-specific, and also establish themselves in the vital inner-body systems. It is concluded that the framework may assist the study of new emerging viruses and pandemic risks.

scholarly journals Clinical characteristics and organ system involvement in sarcoidosis: comparison of the University of Minnesota Cohort with other cohorts

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hok Sreng Te ◽  
David M. Perlman ◽  
Chetan Shenoy ◽  
Daniel J. Steinberger ◽  
Rebecca J. Cogswell ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Organ System ◽  
University Of Minnesota ◽  
System Involvement ◽  
The University
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