scholarly journals Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo

2009 ◽  
Vol 34 (6) ◽  
Author(s):  
Kang
Keyword(s):  
Cell Growth ◽  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell

Silencing of Hypoxia Inducible Factor-1α by RNA Interference Attenuates Human Glioma Cell Growth In vivo

2007 ◽  
Vol 13 (8) ◽  
pp. 2441-2448 ◽  
Author(s):  
David L. Gillespie ◽  
Kum Whang ◽  
Brian T. Ragel ◽  
Jeannette R. Flynn ◽  
David A. Kelly ◽  
...  
Keyword(s):  
Rna Interference ◽  
Cell Growth ◽  
Glioma Cell ◽  
Hypoxia Inducible Factor ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Hypoxia Inducible Factor 1Α

scholarly journals Expression of CYP4A1 in U251 Human Glioma Cell Induces Hyperproliferative Phenotype in Vitro and Rapidly Growing Tumors in Vivo

2008 ◽  
Vol 327 (1) ◽  
pp. 10-19 ◽  
Author(s):  
Austin M. Guo ◽  
Ju Sheng ◽  
Gloria M. Scicli ◽  
Ali S. Arbab ◽  
Norman L. Lehman ◽  
...  
Keyword(s):  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell

Co-delivery of as-miR-21 and 5-FU by Poly(amidoamine) Dendrimer Attenuates Human Glioma Cell Growth in Vitro

2010 ◽  
Vol 21 (3) ◽  
pp. 303-314 ◽  
Author(s):  
Yu Ren ◽  
Chun-Sheng Kang ◽  
Xu-Bo Yuan ◽  
Xuan Zhou ◽  
Peng Xu ◽  
...  
Keyword(s):  
Cell Growth ◽  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell

scholarly journals APO010, a synthetic hexameric CD95 ligand, induces human glioma cell death in vitro and in vivo

2010 ◽  
Vol 13 (2) ◽  
pp. 155-164 ◽  
Author(s):  
G. Eisele ◽  
P. Roth ◽  
K. Hasenbach ◽  
S. Aulwurm ◽  
F. Wolpert ◽  
...  
Keyword(s):  
Cell Death ◽  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Cd95 Ligand

scholarly journals MicroRNA-585 inhibits human glioma cell proliferation by directly targeting MDM2

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wangsheng Chen ◽  
Lan Hong ◽  
Changlong Hou ◽  
Yibin Wang ◽  
Fei Wang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Lines ◽  
Glioma Cell ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Human Glioma Cell ◽  
Glioma Cell Proliferation

Abstract Background MicroRNAs (miRNAs) are important regulators for cancer cell proliferation. miR-585 has been shown to inhibit the proliferation of several types of cancer, however, little is known about its role in human glioma cells. Methods miR-585 levels in human glioma clinical samples and cell lines were examined by quantitative real-time PCR (qRT-PCR) analysis. Cell proliferation was measured by Cell Counting Kit-8 (CCK-8) and EdU incorporation assays in vitro. For in vivo investigations, U251 cells were intracranially inoculated in BALB/c nude mice and xenografted tumors were visualized by magnetic resonance imaging (MRI). Results miR-585 expression is downregulated in human glioma tissues and cell lines compared with non-cancerous counterparts. Additionally, miR-585 overexpression inhibits and its knockdown promotes human glioma cell proliferation in vitro. Moreover, miR-585 overexpression also inhibits the growth of glioma xenografts in vivo, suggesting that miR-585 may act as a tumor suppressor to inhibit the proliferation of human glioma. Furthermore, miR-585 directly targets and decreases the expression of oncoprotein murine double minute 2 (MDM2). More importantly, the restoration of MDM2 via enforced overexpression markedly rescues miR-585 inhibitory effect on human glioma cell proliferation, thus demonstrating that targeting MDM2 is a critical mechanism by which miR-585 inhibits human glioma cell proliferation. Conclusions Our study unveils the anti-proliferative role of miR-585 in human glioma cells, and also implicates its potential application in clinical therapy.

scholarly journals Downregulation of ubiquitin-associated protein 2-like with a short hairpin RNA inhibits human glioma cell growth in vitro

2015 ◽  
Vol 36 (4) ◽  
pp. 1012-1018 ◽  
Author(s):  
BING ZHAO ◽  
GANG ZONG ◽  
YONGSHENG XIE ◽  
JIA LI ◽  
HONGLIANG WANG ◽  
...  
Keyword(s):  
Cell Growth ◽  
Glioma Cell ◽  
Short Hairpin Rna ◽  
Human Glioma ◽  
Hairpin Rna ◽  
Human Glioma Cell ◽  
Short Hairpin
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