Mulberry Fruit (Moris fructus) Extracts Induce Human Glioma Cell Death In Vitro Through ROS-Dependent Mitochondrial Pathway and Inhibits Glioma Tumor Growth In Vivo

2010 ◽  
Vol 62 (3) ◽  
pp. 402-412 ◽  
Author(s):  
Ji Cheon Jeong ◽  
Sang Won Jang ◽  
Thae Hyun Kim ◽  
Chae Hwa Kwon ◽  
Yong Keun Kim
Keyword(s):  
Cell Death ◽  
Tumor Growth ◽  
Glioma Cell ◽  
Mitochondrial Pathway ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Mulberry Fruit ◽  
Glioma Tumor

scholarly journals APO010, a synthetic hexameric CD95 ligand, induces human glioma cell death in vitro and in vivo

2010 ◽  
Vol 13 (2) ◽  
pp. 155-164 ◽  
Author(s):  
G. Eisele ◽  
P. Roth ◽  
K. Hasenbach ◽  
S. Aulwurm ◽  
F. Wolpert ◽  
...  
Keyword(s):  
Cell Death ◽  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell ◽  
Cd95 Ligand

scholarly journals Expression of CYP4A1 in U251 Human Glioma Cell Induces Hyperproliferative Phenotype in Vitro and Rapidly Growing Tumors in Vivo

2008 ◽  
Vol 327 (1) ◽  
pp. 10-19 ◽  
Author(s):  
Austin M. Guo ◽  
Ju Sheng ◽  
Gloria M. Scicli ◽  
Ali S. Arbab ◽  
Norman L. Lehman ◽  
...  
Keyword(s):  
Glioma Cell ◽  
Human Glioma ◽  
Human Glioma Cell

scholarly journals MicroRNA-585 inhibits human glioma cell proliferation by directly targeting MDM2

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wangsheng Chen ◽  
Lan Hong ◽  
Changlong Hou ◽  
Yibin Wang ◽  
Fei Wang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Lines ◽  
Glioma Cell ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Human Glioma Cell ◽  
Glioma Cell Proliferation

Abstract Background MicroRNAs (miRNAs) are important regulators for cancer cell proliferation. miR-585 has been shown to inhibit the proliferation of several types of cancer, however, little is known about its role in human glioma cells. Methods miR-585 levels in human glioma clinical samples and cell lines were examined by quantitative real-time PCR (qRT-PCR) analysis. Cell proliferation was measured by Cell Counting Kit-8 (CCK-8) and EdU incorporation assays in vitro. For in vivo investigations, U251 cells were intracranially inoculated in BALB/c nude mice and xenografted tumors were visualized by magnetic resonance imaging (MRI). Results miR-585 expression is downregulated in human glioma tissues and cell lines compared with non-cancerous counterparts. Additionally, miR-585 overexpression inhibits and its knockdown promotes human glioma cell proliferation in vitro. Moreover, miR-585 overexpression also inhibits the growth of glioma xenografts in vivo, suggesting that miR-585 may act as a tumor suppressor to inhibit the proliferation of human glioma. Furthermore, miR-585 directly targets and decreases the expression of oncoprotein murine double minute 2 (MDM2). More importantly, the restoration of MDM2 via enforced overexpression markedly rescues miR-585 inhibitory effect on human glioma cell proliferation, thus demonstrating that targeting MDM2 is a critical mechanism by which miR-585 inhibits human glioma cell proliferation. Conclusions Our study unveils the anti-proliferative role of miR-585 in human glioma cells, and also implicates its potential application in clinical therapy.

Silibinin Inhibits Glioma Cell Proliferation via Ca2+/ROS/MAPK-Dependent Mechanism In Vitro and Glioma Tumor Growth In Vivo

2009 ◽  
Vol 34 (8) ◽  
pp. 1479-1490 ◽  
Author(s):  
Kwang Won Kim ◽  
Chang Hwa Choi ◽  
Thae Hyun Kim ◽  
Chae Hwa Kwon ◽  
Jae Suk Woo ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Growth ◽  
Glioma Cell ◽  
Glioma Cell Proliferation ◽  
Glioma Tumor ◽  
Dependent Mechanism
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