scholarly journals Expression of the WT1 gene -KTS domain isoforms suppresses the invasive ability of human lung squamous cell carcinoma cells

2008 ◽  
Author(s):  
Shogo Moriya ◽  
Masaki Takiguchi ◽  
Naohiko Seki
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Human Lung ◽  
Lung Squamous Cell Carcinoma ◽  
Carcinoma Cells ◽  
Wt1 Gene ◽  
Invasive Ability

scholarly journals Oxyresveratrol inhibits the growth of human lung squamous cell carcinoma cells by triggering S-phase arrest and apoptosis

2019 ◽  
Vol 6 ◽  
Author(s):  
Cheng-Hsuan Chuang ◽  
Kok-Tong Tan ◽  
Yu-Tang Tung ◽  
Chi-Chien Lin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Human Lung ◽  
Lung Squamous Cell Carcinoma ◽  
Small Cell ◽  
S Phase ◽  
Carcinoma Cells ◽  
Small Cell Lung ◽  
Protein Expressions

Oxyresveratrol is found in mulberry (Morus alba L.) and possesses antioxidant, anti-inflammatory, and antitumor activities. However, to the best of our knowledge, relevant studies on the effects of oxyresveratrol on human lung squamous cell carcinoma cells are lacking. The aim of this study was to evaluate the antitumor activity of oxyresveratrol in human NCI-H520 lung squamous cell carcinoma cells using in vitro and in vivo approaches. Oxyresveratrol induced NCI-H520 cell apoptosis in an intrinsic signaling pathway. Therefore, oxyresveratrol resulted in enhanced cell numbers at the sub-G1 phase, increased caspase-3 and -9 activities, caused the MMP (mitochondrial membrane potential) to collapse, and decreased Bcl-2 and cyclin D protein expressions. In addition, oxyresveratrol induced arrest at the S-phase cell cycle in NCI-H520 cells through downregulating the cell-cycle-related protein expressions of cyclin A, cyclin B, and cdk2. These results indicated that oxyresveratrol inhibited the proliferation and induced apoptosis by activating an intrinsic pathway in NCI-H520 non-small cell lung cancer cells. Our results suggest that oxyresveratrol can be used as an alternative remedy for human non-small-cell lung cancer.

scholarly journals Oxyresveratrol Inhibits the Growth of Human Lung Squamous Cell Carcinoma Cells by Triggering S-phase Arrest and Apoptosis

2019 ◽  
Vol 6 ◽  
Author(s):  
Cheng-Hsuan Chuang ◽  
Kok-Tong Tan ◽  
Yu-Tang Tung ◽  
Chi-Chien Lin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Human Lung ◽  
Lung Squamous Cell Carcinoma ◽  
Small Cell ◽  
S Phase ◽  
Carcinoma Cells ◽  
Small Cell Lung ◽  
Protein Expressions

Oxyresveratrol is found in the mulberry (Morus alba L.) and possesses antioxidant, anti-inflammatory, and antitumor activities. However, to the best of our knowledge, relevant studies on the effects of oxyresveratrol on human lung squamous cell carcinoma cells are lacking. The aim of this study was to evaluate the antitumor activity of oxyresveratrol in human NCI-H520 lung squamous cell carcinoma cells using in vitro and in vivo approaches. Oxyresveratrol induced NCI-H520 cell apoptosis in an intrinsic signaling pathway. Therefore, oxyresveratrol resulted in enhanced cell numbers at the sub-G1 phase, increased caspase-3 and -9 activities, caused the MMP to collapse, and decreased Bcl-2 and cyclin D protein expressions. In addition, oxyresveratrol induced arrest at the S-phase cell cycle in NCI-H520 cells through downregulating the cell-cycle-related protein expressions of cyclin A, cyclin B, and cdk2. These results indicated that oxyresveratrol inhibited the proliferation and induced apoptosis by activating an intrinsic pathway in NCI-H520 non-small cell lung cancer cells. Our results suggest that oxyresveratrol can be used as an alternative remedy for human non-small-cell lung cancer.

Purification of a Tumoral Marker Recognized by Monoclonal Antibody Po66 and Associated with Human Lung Squamous Cell Carcinoma

1996 ◽  
Vol 11 (3) ◽  
pp. 148-152 ◽  
Author(s):  
F. Brichory ◽  
B. Collet ◽  
C. Pineau ◽  
B. Desrues ◽  
L. Toujas ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Squamous Cell ◽  
Human Lung ◽  
Lung Squamous Cell Carcinoma ◽  
Squamous Carcinoma ◽  
Prolonged Retention ◽  
Squamous Carcinoma Cell

Monoclonal antibody (MAb) Po66, a murine IgG1, was raised by immunization against human lung squamous cell carcinoma. When injected intravenously, Po66 showed prolonged retention in the tumor. It recognized an intracellular antigen. The human lung squamous carcinoma cell line SK-MES-1 expresses the antigen recognized by MAb Po66 and was used as a source of biological material for its purification. The SK-MES-1 cell line was labeled in culture with [35S]methionine and its lysate was immunoprecipitated with Po66 immobilized on Protein G-Sepharose. The precipitate contained three proteins (47, 50 and 69 kDa) absent in the controls. The 69 kDa polypeptide was further purified by anion exchange and immunoaffinity chromatographies. To date, no other tumor marker expressed in non-small cell lung cancer with these characteristics has been described and as such this marker is interesting for future use in immunotherapy and in diagnosis.

scholarly journals Identification of reference genes for qRT-PCR in human lung squamous-cell carcinoma by RNA-Seq

2014 ◽  
Vol 46 (4) ◽  
pp. 330-337 ◽  
Author(s):  
Cheng Zhan ◽  
Yongxing Zhang ◽  
Jun Ma ◽  
Lin Wang ◽  
Wei Jiang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Reference Genes ◽  
Human Lung ◽  
Lung Squamous Cell Carcinoma ◽  
Rna Seq ◽  
Qrt Pcr

scholarly journals Terminal N-Acetylgalactosamine-Specific Leguminous Lectin from Wisteria japonica as a Probe for Human Lung Squamous Cell Carcinoma

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e83886 ◽  
Author(s):  
Keisuke Soga ◽  
Futaba Teruya ◽  
Hiroaki Tateno ◽  
Jun Hirabayashi ◽  
Kazuo Yamamoto
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Human Lung ◽  
Lung Squamous Cell Carcinoma ◽  
Leguminous Lectin
Sign in / Sign up

Export Citation Format

Share Document