Evaluation of Hypocrellin B in a human bladder tumor model in experimental photodynamic therapy: Biodistribution, light dose and drug-light interval effects

2004 ◽  
Author(s):  
William Chin ◽  
Weber Lau ◽  
Christopher Cheng ◽  
Malini Olivo
Keyword(s):  
Photodynamic Therapy ◽  
Bladder Tumor ◽  
Tumor Model ◽  
Light Dose ◽  
Human Bladder ◽  
Hypocrellin B

Combination of angiogenesis inhibitors increases the anti-tumor efficacy of photodynamic therapy in a human bladder tumor xenograft model

2009 ◽  
Author(s):  
Ramaswamy Bhuvaneswari ◽  
Yik Yuen Gan ◽  
Patricia S. P. Thong ◽  
William Wei L. Chin ◽  
Khee Chee Soo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Bladder Tumor ◽  
Xenograft Model ◽  
Angiogenesis Inhibitors ◽  
Tumor Xenograft ◽  
Human Bladder

scholarly journals PHOTODYNAMIC THERAPY WITH PAD-S31, A NEW HYDROPHILIC CHLORIN PHOTOSENSITIZER, IN AN ORTHOTOPIC RAT BLADDER TUMOR MODEL

2005 ◽  
Vol 174 (5) ◽  
pp. 2016-2021 ◽  
Author(s):  
HIROSHI ASANUMA ◽  
TSUNENORI ARAI ◽  
YUJI MORIMOTO ◽  
SATOKO KAWAUCHI ◽  
HIROYUKI SATOH ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Bladder Tumor ◽  
Tumor Model ◽  
Rat Bladder

Targeting bladder tumor cells in vivo and in the urine by a peptide identified using phage display

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10071-10071
Author(s):  
T. Kwon ◽  
B. Lee ◽  
E. Yoo ◽  
S. Chung ◽  
Y. Park ◽  
...  
Keyword(s):  
Phage Display ◽  
Tumor Cells ◽  
Bladder Tumor ◽  
Tumor Model ◽  
Human Bladder ◽  
Selective Binding ◽  
Tumor Xenografts ◽  
Tumor Tissues ◽  
Fluorescent Peptide

10071 Background: Bladder cancer is one of the most common tumors of genitourinary tract. Selective delivery of drugs to tumor tissues is important for effective tumor therapy. Here we identified a peptide targeting bladder tumor cells using phage display. Methods: Phage peptide library containing CX7C (C-cysteine and X-any amino acid residue) was based on T7 415–1b phage vector (Novagen). Tumor xenografts were prepared by subcutaneously injecting BALB/c Nu/nu female nude mice with HT-1376 bladder tumor cells. For a carcinogen-induced tumor model, Fischer 344 female rats were supplied ad libitum with tap water containing 0.05% N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) for 8 weeks. Results: A phage library containing CX7C random peptides was screened for selective binding to cells from human bladder tumor xenografts. Selected phage clones were individually evaluated for binding to cultured bladder tumor cells and for binding to cells from human tumor tissues of six patients. The peptide displayed by the most promising clone was synthesized and designated as Bld-1. Fluorescein-conjugated Bld-1 peptide showed selective binding to frozen sections of human bladder tumor tissues of three patients. In vivo tumor targeting was examined in a carcinogen-induced rat tumor model (n=20). When the fluorescent peptide was introduced into the bladder lumen, it selectively bound to tumor epithelium. Next, when the fluorescent peptide was intravenously injected into the tail vein, it homed to the bladder tumor, but was not detectable in normal bladder and control organs such as lung. Moreover, the fluorescent peptide bound to cells from urinary specimens of tumor patients (n=10), whereas little binding was observed in cells from healthy individuals (n=3). Conclusions: The Bld-1 peptide may be useful for targeting bladder tumor cells in vivo and in the urine. No significant financial relationships to disclose.

Antiangiogenesis agents avastin and erbitux enhance the efficacy of photodynamic therapy in a murine bladder tumor model

2011 ◽  
Vol 43 (7) ◽  
pp. 651-662 ◽  
Author(s):  
Ramaswamy Bhuvaneswari ◽  
Gan Yik Yuen ◽  
Soo Khee Chee ◽  
Malini Olivo
Keyword(s):  
Photodynamic Therapy ◽  
Bladder Tumor ◽  
Tumor Model

Importance of fluence rate in photodynamic therapy with ALA-induced PpIX and BPD-MA in a rat bladder tumor model

1995 ◽  
Author(s):  
Seiichi Iinuma ◽  
Georges A. Wagnieres ◽  
Kevin T. Schomacker ◽  
Mike Bamberg ◽  
Tayyaba Hasan
Keyword(s):  
Photodynamic Therapy ◽  
Bladder Tumor ◽  
Tumor Model ◽  
Fluence Rate ◽  
Rat Bladder

Effects of Photodynamic Therapy in Combination with Intravesical Drugs in a Murine Bladder Tumor Model

1992 ◽  
Vol 147 (3 Part 1) ◽  
pp. 743-746 ◽  
Author(s):  
Yong-Hyun Cho ◽  
Richard C. Straight ◽  
Joseph A. Smith
Keyword(s):  
Photodynamic Therapy ◽  
Bladder Tumor ◽  
Tumor Model

PHOTODYNAMIC THERAPY IN THE TREATMENT OF SUBCUTANEOUSLY IMPLANTED HUMAN BLADDER TUMOUR

1992 ◽  
Vol 62 (8) ◽  
pp. 643-649 ◽  
Author(s):  
Wen-Ruo Han ◽  
John S. Hill ◽  
Stan S. Stylli ◽  
Andrew H. Kaye
Keyword(s):  
Photodynamic Therapy ◽  
Bladder Tumour ◽  
Human Bladder ◽  
Human Bladder Tumour
Sign in / Sign up

Export Citation Format

Share Document