Combination of angiogenesis inhibitors increases the anti-tumor efficacy of photodynamic therapy in a human bladder tumor xenograft model

2009 ◽  
Author(s):  
Ramaswamy Bhuvaneswari ◽  
Yik Yuen Gan ◽  
Patricia S. P. Thong ◽  
William Wei L. Chin ◽  
Khee Chee Soo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Bladder Tumor ◽  
Xenograft Model ◽  
Angiogenesis Inhibitors ◽  
Tumor Xenograft ◽  
Human Bladder

scholarly journals Development of an ErbB-overexpressing A-431 Optical Reporting Tumor Xenograft Model to Assess Targeted Photodynamic Therapy Regimens

2010 ◽  
Vol 86 (6) ◽  
pp. 1379-1389 ◽  
Author(s):  
Mark D. Savellano ◽  
Nicci Owusu-Brackett ◽  
Ji Son ◽  
Thierri Callier ◽  
Dagmar Högemann Savellano
Keyword(s):  
Photodynamic Therapy ◽  
Xenograft Model ◽  
Tumor Xenograft ◽  
Targeted Photodynamic Therapy

Nicotinamide Inhibits Growth of Carcinogen Induced Mouse Bladder Tumor and Human Bladder Tumor Xenograft Through Up-Regulation of RUNX3 and p300

2011 ◽  
Vol 185 (6) ◽  
pp. 2366-2375 ◽  
Author(s):  
Wun-Jae Kim ◽  
Jung-Won Lee ◽  
Changyi Quan ◽  
Hyung-Joon Youn ◽  
Hwan-Mook Kim ◽  
...  
Keyword(s):  
Bladder Tumor ◽  
Tumor Xenograft ◽  
Human Bladder

scholarly journals LINC00958 promotes the proliferation of TSCC via miR-211-5p/CENPK axis and activating the JAK/STAT3 signaling pathway

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bo Jia ◽  
Junfeng Dao ◽  
Jiusong Han ◽  
Zhijie Huang ◽  
Xiang Sun ◽  
...  
Keyword(s):  
Noncoding Rna ◽  
Xenograft Model ◽  
Tumor Xenograft ◽  
Luciferase Reporter ◽  
Cell Cycle Regulators ◽  
Normal Tissues ◽  
Stat3 Signaling ◽  
Long Intergenic Noncoding Rna

Abstract Background Tongue squamous cell carcinoma (TSCC) is one of the most common oral tumors. Recently, long intergenic noncoding RNA 00958 (LINC00958) has been identified as an oncogene in human cancers. Nevertheless, the role of LINC00958 and its downstream mechanisms in TSCC is still unknown. Methods The effect of LINC00958 on TSCC cells proliferation and growth were assessed by CCK-8, colony formation, 5-Ethynyl-2′-deoxyuridline (EdU) assay and flow cytometry assays in vitro and tumor xenograft model in vivo. Bioinformatics analysis was used to predict the target of LINC00958 in TSCC, which was verified by RNA immunoprecipitation and luciferase reporter assays. Results LINC00958 was increased in TSCC tissues, and patients with high LINC00958 expression had a shorter overall survival. LINC00958 knockdown significantly decreased the growth rate of TSCC cells both in vitro and in vivo. In mechanism, LINC00958 acted as a ceRNA by competitively sponging miR-211-5p. In addition, we identified CENPK as a direct target gene of miR-211-5p, which was higher in TSCC tissues than that in adjacent normal tissues. Up-regulated miR-211-5p or down-regulated CENPK could abolish LINC00958-induced proliferation promotion in TSCC cells. Furthermore, The overexpression of CENPK promoted the expression of oncogenic cell cycle regulators and activated the JAK/STAT3 signaling. Conclusions Our findings suggested that LINC00958 is a potential prognostic biomarker in TSCC.

PHOTODYNAMIC THERAPY IN THE TREATMENT OF SUBCUTANEOUSLY IMPLANTED HUMAN BLADDER TUMOUR

1992 ◽  
Vol 62 (8) ◽  
pp. 643-649 ◽  
Author(s):  
Wen-Ruo Han ◽  
John S. Hill ◽  
Stan S. Stylli ◽  
Andrew H. Kaye
Keyword(s):  
Photodynamic Therapy ◽  
Bladder Tumour ◽  
Human Bladder ◽  
Human Bladder Tumour

scholarly journals Gamma-radiated immunosuppressed tumor xenograft mice can be a new ideal model in cancer research

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hamid Khodayari ◽  
Saeed Khodayari ◽  
Solmaz Khalighfard ◽  
Arash Tahmasebifar ◽  
Mahboubeh Tajaldini ◽  
...  
Keyword(s):  
Gamma Radiation ◽  
High Capacity ◽  
Xenograft Model ◽  
Tumor Xenograft ◽  
Whole Body ◽  
Cell Injection ◽  
Tumor Tissues ◽  
Post Radiation ◽  
Xenograft Models ◽  
Xenograft Mice

AbstractTumor xenograft models can create a high capacity to study human tumors and discover efficient therapeutic approaches. Here, we aimed to develop the gamma-radiated immunosuppressed (GIS) mice as a new kind of tumor xenograft model for biomedical studies. First, 144 mice were divided into the control and treated groups exposed by a medical Cobalt-60 apparatus in 3, 4, and 5 Gy based on the system outputs. Then, 144 BALB/c mice were divided into four groups; healthy, xenograft, radiation, and radiation + xenograft groups. The animals in the xenograft and radiation + xenograft groups have subcutaneously received 3 × 106 MCF-7 cells 24 h post-radiation. On 3, 7, 14, and 21 days after cell injection, the animals were sacrificed. Then, the blood samples and the spleen and tumor tissues were removed for the cellular and molecular analyses. The whole-body gamma radiation had a high immunosuppressive effect on the BALB/c mice from 1 to 21 days post-radiation. The macroscopic and histopathological observations have proved that the created clusters' tumor structure resulted in the xenograft breast tumor. There was a significant increase in tumor size after cell injection until the end of the study. Except for Treg, the spleen level of CD4, CD8, CD19, and Ly6G was significantly decreased in Xen + Rad compared to the Xen alone group on 3 and 7 days. Unlike IL-4 and IL-10, the spleen level of TGF-β, INF-γ, IL-12, and IL-17 was considerably decreased in the Xen + Rad than the Xen alone group on 3 and 7 days. The spleen expressions of the VEGF, Ki67, and Bax/Bcl-2 ratio were dramatically increased in the Xen + Rad group compared to the Xen alone on 3, 7, 14, and 21 days. Our results could confirm a new tumor xenograft model via an efficient immune-suppressive potential of the whole-body gamma radiation in mice.

Effect of angiotensin II type 1 receptor antagonist on tumor growth and angiogenesis in a xenograft model of human bladder cancer

Human Cell ◽  
2007 ◽  
Vol 20 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Michio KOSUGI ◽  
Akira MIYAJIMA ◽  
Eiji KIKUCHI ◽  
Takeo KOSAKA ◽  
Yutaka HORIGUCHI ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Angiotensin Ii ◽  
Tumor Growth ◽  
Receptor Antagonist ◽  
Xenograft Model ◽  
Human Bladder Cancer ◽  
Human Bladder
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