scholarly journals Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis

2018 ◽  
Author(s):  
Honglei Wang ◽  
Yi Xiao ◽  
Li Wu ◽  
Dachang Ma
Keyword(s):  
Circular Rna ◽  
Regulatory Role ◽  
Breast Carcinogenesis ◽  
Rna Profiling

scholarly journals Comprehensive circular RNA profiling reveals the regulatory role of circ_100242/miR-145 pathway in bladder cancer

2020 ◽  
Author(s):  
Zhaowei Zhu ◽  
Fujiang Chang ◽  
Junxiao Liu ◽  
Jiange Wang ◽  
Xuepei Zhang
Keyword(s):  
Bladder Cancer ◽  
Circular Rna ◽  
Regulatory Role ◽  
Rna Profiling

scholarly journals Circular RNA profiling reveals a potential role of hsa_circ_IPCEF1 in papillary thyroid carcinoma

2021 ◽  
Vol 24 (2) ◽  
Author(s):  
Min Guo ◽  
Yushuang Sun ◽  
Junzhu Ding ◽  
Yong Li ◽  
Sihan Yang ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Potential Role ◽  
Circular Rna ◽  
Papillary Thyroid ◽  
Rna Profiling

scholarly journals Comprehensive Circular RNA Profiling Reveals the Regulatory Role of the CircRNA-0067835/miR-155 Pathway in Temporal Lobe Epilepsy

2018 ◽  
Vol 51 (3) ◽  
pp. 1399-1409 ◽  
Author(s):  
Guo-Hua Gong ◽  
Feng-Mao An ◽  
Yu Wang ◽  
Ming Bian ◽  
Di Wang ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Circular Rna ◽  
Fine Tuning ◽  
Luciferase Reporter ◽  
Circular Rnas ◽  
G1 Arrest ◽  
Rna Profiling

Background/Aims: Temporal lobe epilepsy (TLE) is the most common form of adult localization-related epilepsy that is accompanied by progressive etiopathology and high incidences of drug resistance. Circular RNAs (circRNAs) play important roles in fine-tuning gene expression, however, the expression profile and clinical significance of circRNAs in TLE remains unknown. Methods: Circular RNA microarray was conducted to identify TLE-related circRNAs. CCK8 assays and flow cytometric assays were conducted to clarify the role of circRNA in TLE in vitro. Bioinformatics analysis and in vitro experiments were conducted to clarify the mechanism of circRNA-mediated gene regulation in TLE cell. Results: 586 differentially expressed circRNAs were identified between TLE and the control tissues. The expression of circRNA-0067835 was significantly down-regulated in tissues and plasma from TLE patients. Lower circRNA-0067835 correlated to increased seizure frequency, HS, and higher Engel’s score. Overexpression of circRNA-0067835 observably decreased SH-SY5Y cell proliferation by causing G1 arrest and promoting apoptosis. Bioinformatics online programs predicted that circRNA-0067835 acted as miR-155 sponge to regulate FOXO3a expression, which was validated using luciferase reporter assay. Conclusion: Our experiments showed that circRNA-0067835 regulated refractory epilepsy progression by acting as a sponge of miR-155 to promote FOXO3a expression, indicating that circRNA-0067835 may serve as a potential therapeutic target for patients with TLE.

Regulatory role of resistin on ovarian function

2014 ◽  
Author(s):  
Agnieszka Rak-Mardyla ◽  
Anna Wrobel ◽  
Eliza Drwal ◽  
Ewa Gregoraszczuk
Keyword(s):  
Ovarian Function ◽  
Regulatory Role
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