scholarly journals TGF-β1 induces HMGA1 expression: The role of HMGA1 in thyroid cancer proliferation and invasion

2017 ◽  
Vol 50 (5) ◽  
pp. 1567-1578 ◽  
Author(s):  
Jing Zhong ◽  
Chang Liu ◽  
Qing Hai Zhang ◽  
Ling Chen ◽  
Ying-Ying Shen ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Proliferation ◽  
Hmga1 Expression ◽  
Proliferation And Invasion ◽  
Tgf Β1

scholarly journals The inhibitory role of miR‑485‑5p in colorectal cancer proliferation and invasion via targeting of CD147

2018 ◽  
Author(s):  
Yuqin Pan ◽  
Huiling Sun ◽  
Xiuxiu Hu ◽  
Bangshun He ◽  
Xiangxiang Liu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Proliferation ◽  
Inhibitory Role ◽  
Proliferation And Invasion

scholarly journals AUF1 Promotes Proliferation and Invasion of Thyroid Cancer via Downregulation of ZBTB2 and Subsequent TRIM58

2021 ◽  
Vol 11 ◽  
Author(s):  
Xin Du ◽  
Jia-Mei Wang ◽  
Da-Lin Zhang ◽  
Tong Wu ◽  
Xiao-Yan Zeng ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Binding Sites ◽  
Critical Role ◽  
Common Type ◽  
Migration And Invasion ◽  
Papillary Thyroid ◽  
Thyroid Cancer Cells ◽  
Proliferation And Invasion

The pathogenesis of papillary thyroid cancer (PTC), the most common type of thyroid cancer, is not yet fully understood. This limits the therapeutic options for approximately 7% of invasive PTC patients. The critical role of AUF1 in the progression of thyroid cancer was first reported in 2009, however, its molecular mechanism remained unclear. Our study used CRISPR/Cas 9 system to knockdown AUF1 in IHH4 and TPC1 cells. We noticed that the expression of TRIM58 and ZBTB2 were increased in the AUF1 knockdown IHH4 and TPC1 cells. When TRIM58 and ZBTB2 were inhibited by small hairpin RNAs (shRNAs) against TRIM58 (shTRIM58) and ZBTB2 (shZBTB2), respectively, the proliferation, migration, and invasion ability of the AUF1-knockdown IHH4 and TPC1 cells were increased. In addition, two ZBTB2 binding sites (-719~-709 and -677~-668) on TRIM58 promoter and two AUF1 binding sites (1250-1256 and 1258-1265) on ZBTB2 3’-UTR were identified. These results suggested that AUF1 affecting thyroid cancer cells via regulating the expression of ZBTB2 and TRIM58.

scholarly journals MicroRNA-96-5p represses breast cancer proliferation and invasion through Wnt/β-catenin signaling via targeting CTNND1

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiao-hui Gao ◽  
Ya-li Zhang ◽  
Zhi-ye Zhang ◽  
Shuang-shuang Guo ◽  
Xiao-bing Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cyclin D1 ◽  
Cancer Proliferation ◽  
Invasive Capacity ◽  
Novel Target ◽  
Proliferation And Invasion

AbstractLow miR-96-5p expression is characteristic of many cancers but its role in breast cancer (BCa) remains poorly defined. Here, the role of miR-96-5p in BC development was assessed. We demonstrate that exogenously expressing miR-96-5p inhibits the proliferative, migratory and invasive capacity of BCa cells. Mechanistically, miR-96-5p in BCa cells was found to target and downregulate catenin delta 1 (CTNND1) leading to decreased β-catenin expression, a loss of WNT11 signaling, reduced cyclin D1 levels and lower MMP7 expression. Exogenously expressing CTNND1 alleviated these effects. In summary, we are the first to reveal that miR-96-5p inhibits the proliferative, invasive and migratory phenotypes of BCa cells the targeting of CTNND1 and subsequent Wnt/β-catenin signaling. These data highlight miR-96-5p as a novel target for BC treatment.

miR‐206 inhibits thyroid cancer proliferation and invasion by targeting RAP1B

2019 ◽  
Vol 120 (11) ◽  
pp. 18927-18936 ◽  
Author(s):  
Peng Wang ◽  
Jialei Gu ◽  
Kejing Wang ◽  
Jinbiao Shang ◽  
Wendong Wang
Keyword(s):  
Thyroid Cancer ◽  
Cancer Proliferation ◽  
Proliferation And Invasion

scholarly journals microRNA-141 inhibits TGF-β1-induced epithelial-to-mesenchymal transition through inhibition of the TGF-β1/SMAD2 signalling pathway in endometriosis

2020 ◽  
Vol 301 (3) ◽  
pp. 707-714 ◽  
Author(s):  
Sixue Wang ◽  
Mengmeng Zhang ◽  
Tingting Zhang ◽  
Juan Deng ◽  
Xiaomeng Xia ◽  
...  
Keyword(s):  
Epithelial To Mesenchymal Transition ◽  
Transforming Growth Factor ◽  
Signalling Pathway ◽  
Functional Assay ◽  
Transforming Growth Factor Beta1 ◽  
Mesenchymal Transition ◽  
Polymerase Chain ◽  
Proliferation And Invasion ◽  
Tgf Β1

Abstract Purpose Recent studies have demonstrated the differential expression of micro(mi)RNAs in endometriosis. Previously, we reported the low expression of miR-141 in patients with this disease. Epithelial-to-mesenchymal transition (EMT) and the transforming growth factor-beta1 (TGF-β1)-induced SMAD2 signalling pathway are central to tumour proliferation and invasion. However, the role of miR-141 in regulating the TGF-β1/SMAD2 signalling pathway and the associated EMT to be elucidated. Methods The levels of TGF-β1/SMAD2 signalling and EMT markers expression in eutopic and ectopic endometria of endometriosis were determined by immunohistochemistry and western blot analyses. MiR-141 expression was analysed by quantitative reverse-transcription polymerase chain reaction. Cellular invasion and proliferation were determined by transwell and CCK-8 assays, respectively. Functional assay of miR-141 was performed using plasmid and shRNA transfection methods. Result The presence of miR-141, EMT, and TGF-β1/SMAD2 signalling markers were detected in eutopic and ectopic endometria of endometriosis. TGF-β1-induced EMT in Ishikawa (ISK) cells by activating the SMAD2 signalling pathway, whereas miR-141 inhibited the TGF-β1-induced EMT, proliferation and invasion abilities of these cells. Conclusion These data identify miR-141 as a novel driver of EMT in endometriosis, implicates the link between miR-141 and TGF-β1/SMAD2 signalling pathway in the context of endometriosis, and underscore the role of EMT in the development of endometriosis.

scholarly journals The association between S100A13 and HMGA1 in the modulation of thyroid cancer proliferation and invasion

2016 ◽  
Vol 14 (1) ◽  
Author(s):  
Jing Zhong ◽  
Chang Liu ◽  
Ya-jun Chen ◽  
Qing-hai Zhang ◽  
Jing Yang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Proliferation ◽  
Proliferation And Invasion

The role of radioiodine SPECT/CT in differentiated thyroid cancer

2013 ◽  
Author(s):  
Emese Mezosi ◽  
Laszlo Bajnok ◽  
Karoly Rucz ◽  
Csaba Weninger ◽  
Erzsebet Schmidt ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer

The role of preoperative serum thyroglobulin values in the diagnosis of differentiated thyroid cancer

2017 ◽  
Author(s):  
Blertina Dyrmishi ◽  
Taulant Olldashi ◽  
Ema Lumi ◽  
Entela Puca ◽  
Dorina Ylli ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Serum Thyroglobulin ◽  
Preoperative Serum
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