scholarly journals Combined oridonin with cetuximab treatment shows synergistic anticancer effects on laryngeal squamous cell carcinoma: Involvement of inhibition of EGFR and activation of reactive oxygen species-mediated JNK pathway

2016 ◽  
Vol 49 (5) ◽  
pp. 2075-2087 ◽  
Author(s):  
Shijie Cao ◽  
Meijuan Xia ◽  
Yiwei Mao ◽  
Qiang Zhang ◽  
Paul Owusu Donkor ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Jnk Pathway ◽  
Anticancer Effects

Genkwadaphnin induces reactive oxygen species (ROS)-mediated apoptosis of squamous cell carcinoma (SCC) cells

2014 ◽  
Vol 450 (2) ◽  
pp. 1115-1119 ◽  
Author(s):  
Zheng Jun Li ◽  
Xue Mei Li ◽  
Yong Jun Piao ◽  
Dae-Kyoung Choi ◽  
Sue Jeong Kim ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Reactive Oxygen ◽  
Oxygen Species

Promotion of Ferroptosis in Oral Cancer Cell Lines by Chrysophanol

2019 ◽  
Vol 18 (3) ◽  
pp. 273-276
Author(s):  
Lin Ya-Hsuan ◽  
Chiu Valeria ◽  
Huang Chun-Yen ◽  
Tzeng I-Shiang ◽  
Hsieh Po-Chun ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Oral Cancer ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Cancer Cell ◽  
Squamous Cell ◽  
Reactive Oxygen ◽  
Oxygen Species

Oral cancer is a type of head and neck cancer that can be life threatening if not diagnosed and treated early. Ferroptosis is a type of programmed or regulated cell death dependent on iron and reactive oxygen species but is a caspase-independent form of non-apoptotic cell death. Therefore, there is a need to identify candidate natural compound that may attenuate carcinogenesis through ferroptosis. To this end, we determined the pharmacological effects of chrysophanol on ferroptosis in two different oral cancer cell lines—FaDu, a hypopharyngeal squamous cell carcinoma and SAS, a poorly differentiated squamous cell carcinoma cell line from human tongue primary lesion. Results indicated that chrysophanol caused overproduction of lipid reactive oxygen species, decreased the level of glutathione peroxidase 4, and increased the level of lipocalin-2 and CCAAT-enhancer-binding protein homologous protein. These findings suggest that chrysophanol has the therapeutic potential to alleviate the progression of oral carcinogenesis through activation of ferroptosis.

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