scholarly journals Pancreatic ductal adenocarcinoma cell lines display a plastic ability to bi-directionally convert into cancer stem cells

2014 ◽  
Vol 46 (3) ◽  
pp. 1099-1108 ◽  
Author(s):  
ELISA DALLA POZZA ◽  
ILARIA DANDO ◽  
GIULIA BIONDANI ◽  
JESSICA BRANDI ◽  
CHIARA COSTANZO ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Cell Lines ◽  
Ductal Adenocarcinoma ◽  
Adenocarcinoma Cell

scholarly journals MicroRNA-132 Plays an Independent Prognostic Role in Pancreatic Ductal Adenocarcinoma and Acts as a Tumor Suppressor

2019 ◽  
Vol 18 ◽  
pp. 153303381882431 ◽  
Author(s):  
Yan Chen ◽  
Huiyun Zhu ◽  
Yuqiong Wang ◽  
Yingxiao Song ◽  
Pingping Zhang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Protein Kinase ◽  
Prognostic Factor ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Cell Lines ◽  
Mitogen Activated Protein Kinase ◽  
Ductal Adenocarcinoma ◽  
Adenocarcinoma Cell ◽  
Nuclear Transcription Factor ◽  
Mitogen Activated Protein

The role of microRNA-132 in human pancreatic ductal adenocarcinomas is still ambiguous. We explored the association between microRNA-132 and pancreatic ductal adenocarcinoma prognosis. The expression of microRNA-132 in 50 pancreatic ductal adenocarcinoma tissue samples and pancreatic ductal adenocarcinoma cell lines was examined, and the association between its expression and pancreatic ductal adenocarcinoma prognosis was assessed. Functional analysis and factors downstream of microRNA-132 were investigated. Kaplan-Meier survival curves showed that high expression of microRNA-132 was a significant prognostic factor for 1-year survival of patients with pancreatic ductal adenocarcinoma ( P = .028). Multivariate analysis for overall survival indicated that high expression of microRNA-132 was an independent prognostic factor for patients with pancreatic ductal adenocarcinoma ( P = .044). Low expression of microRNA-132 was associated with poor prognosis in pancreatic ductal adenocarcinoma. Ectopic expression of microRNA-132 significantly inhibited proliferation and promoted apoptosis of 2 pancreatic ductal adenocarcinoma cell lines. Bioinformatic analysis revealed that microRNA-132 may exert its effects on pancreatic ductal adenocarcinoma through downregulating mitogen-activated protein kinase 3 and nuclear transcription factor Y subunit α. The results of this study further our understanding of the relationship between microRNA-132 and pancreatic ductal adenocarcinoma by showing that microRNA-132 might inhibit the progression of pancreatic ductal adenocarcinoma by regulating mitogen-activated protein kinase and nuclear transcription factor Y subunit alpha.

scholarly journals Oncolytic Activity of Avian Influenza Virus in Human Pancreatic Ductal Adenocarcinoma Cell Lines

2014 ◽  
Vol 88 (16) ◽  
pp. 9321-9334 ◽  
Author(s):  
S. B. Kasloff ◽  
M. S. Pizzuto ◽  
M. Silic-Benussi ◽  
S. Pavone ◽  
V. Ciminale ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Cell Lines ◽  
Ductal Adenocarcinoma ◽  
Adenocarcinoma Cell ◽  
Oncolytic Activity

scholarly journals Comparative Proteomic Profiling of Pancreatic Ductal Adenocarcinoma Cell Lines

2014 ◽  
Vol 37 (12) ◽  
pp. 888-898 ◽  
Author(s):  
Yikwon Kim ◽  
Dohyun Han ◽  
Hophil Min ◽  
Jonghwa Jin ◽  
Eugene C. Yi ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Cell Lines ◽  
Ductal Adenocarcinoma ◽  
Proteomic Profiling ◽  
Adenocarcinoma Cell
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