scholarly journals Coexpression of CD44‐positive/CD133‐positive cancer stem cells and CD204‐positive tumor‐associated macrophages is a predictor of survival in pancreatic ductal adenocarcinoma

Cancer ◽  
2014 ◽  
Vol 120 (17) ◽  
pp. 2766-2777 ◽  
Author(s):  
Ya‐Chin Hou ◽  
Ying‐Jui Chao ◽  
Hui‐Ling Tung ◽  
Hao‐Chen Wang ◽  
Yan‐Shen Shan
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma ◽  
Tumor Associated Macrophages

scholarly journals Pancreatic ductal adenocarcinoma cell lines display a plastic ability to bi-directionally convert into cancer stem cells

2014 ◽  
Vol 46 (3) ◽  
pp. 1099-1108 ◽  
Author(s):  
ELISA DALLA POZZA ◽  
ILARIA DANDO ◽  
GIULIA BIONDANI ◽  
JESSICA BRANDI ◽  
CHIARA COSTANZO ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Cell Lines ◽  
Ductal Adenocarcinoma ◽  
Adenocarcinoma Cell

Expression of stem cell markers in pancreatic ductal adenocarcinoma and clinical relevance.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e15058-e15058
Author(s):  
Kalliopi Andrikou ◽  
Luca Faloppi ◽  
Cristian Loretelli ◽  
Alessandra Mandolesi ◽  
Italo Bearzi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Univariate Analysis ◽  
Human Pancreatic Cancer ◽  
Ductal Adenocarcinoma ◽  
Small Subset ◽  
Stem Cell Markers ◽  
Cell Markers

e15058 Background: Emerging evidence has suggested that malignant tumors are heterogeneous and that are composed of a small subset of distinct cancer cells (usually defined by cell surface marker expression) that are responsible for tumor initiation and propagation, termed cancer stem cells. These cancer stem cells (CSCs), or tumor-initiating cells (TICs), exhibit properties of normal stem cells and are associated with resistance to current therapies. It was found that human pancreatic cancer has shown a population of cancer stem cells that have aberrantly activated developmental signaling pathways, are resistant to standard chemotherapy and radiation, and have up-regulated signaling cascades that are integral for tumor metastasis. The aim of our study is to investigate the prognostic implication of cancer stem cell markers in pancreatic ductal adenocarcinoma. Methods: In 43 histological samples of pancreatic ductal adenocarcinoma were performed molecular biology assessment of CD 24, CD44, CD133, CD166, OCT3/4, LGR5. Results: At univariate analysis patients with an overexpression of CD44, CD133, OCT3/4 showed a worse prognosis in terms of overall survival (respectively: p=0.031; p=0.014; p=0.001). At multivariate analysis OCT3/4 resulted to be independent factor influencing outcome (HR=0.23). Patients with overexpression of all factors seem to have a worse OS compared to patients expressing only two, one or none (8.6 vs. 15.6 vs. 18.0 vs. 59.9 mts; p=0.006). Conclusions: Our data suggest that the presence of cancer stem cells could be linked with tumor aggressiveness and patients’ survival. This finding could drive therapeutic decision towards less or more intensive treatment.

Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma

Oncogene ◽  
2020 ◽  
Vol 40 (1) ◽  
pp. 215-231
Author(s):  
Rama Krishna Nimmakayala ◽  
Frank Leon ◽  
Satyanarayana Rachagani ◽  
Sanchita Rauth ◽  
Palanisamy Nallasamy ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Metabolic Programming ◽  
Ductal Adenocarcinoma

scholarly journals EMT and Stemness—Key Players in Pancreatic Cancer Stem Cells

Cancers ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1136 ◽  
Author(s):  
Eva Rodriguez-Aznar ◽  
Lisa Wiesmüller ◽  
Bruno Sainz ◽  
Patrick C. Hermann
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Tumor Progression ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Cancer Progression ◽  
Epithelial To Mesenchymal Transition ◽  
Developmental Process ◽  
Therapy Resistance ◽  
Ductal Adenocarcinoma ◽  
Mesenchymal Transition

Metastasis and tumor progression are the major cause of death in patients suffering from pancreatic ductal adenocarcinoma. Tumor growth and especially dissemination are typically associated with activation of an epithelial-to-mesenchymal transition (EMT) program. This phenotypic transition from an epithelial to a mesenchymal state promotes migration and survival both during development and in cancer progression. When re-activated in pathological contexts such as cancer, this type of developmental process confers additional stemness properties to specific subsets of cells. Cancer stem cells (CSCs) are a subpopulation of cancer cells with stem-like features that are responsible for the propagation of the tumor as well as therapy resistance and cancer relapse, but also for circulating tumor cell release and metastasis. In support of this concept, EMT transcription factors generate cells with stem cell properties and mediate chemoresistance. However, their role in pancreatic ductal adenocarcinoma metastasis remains controversial. As such, a better characterization of CSC populations will be crucial in future development of therapies targeting these cells. In this review, we will discuss the latest updates on the mechanisms common to pancreas development and CSC-mediated tumor progression.

scholarly journals Isolation and in Vitro Culture of Rare Cancer Stem Cells from Patient-Derived Xenografts of Pancreatic Ductal Adenocarcinoma

2013 ◽  
Vol 85 (15) ◽  
pp. 7271-7278 ◽  
Author(s):  
Philip C. Gach ◽  
Peter J. Attayek ◽  
Gabriela Herrera ◽  
Jen Jen Yeh ◽  
Nancy L. Allbritton
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
In Vitro Culture ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma ◽  
Rare Cancer

Role of cancer stem cells in pancreatic ductal adenocarcinoma

2009 ◽  
Vol 6 (10) ◽  
pp. 580-586 ◽  
Author(s):  
Gregory Sergeant ◽  
Hugo Vankelecom ◽  
Lies Gremeaux ◽  
Baki Topal
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma
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