scholarly journals Role of the staphylococcal nuclease and tudor domain containing 1 in oncogenesis (Review)

2014 ◽  
Vol 46 (2) ◽  
pp. 465-473 ◽  
Author(s):  
NIDHI JARIWALA ◽  
DEVARAJA RAJASEKARAN ◽  
JYOTI SRIVASTAVA ◽  
RACHEL GREDLER ◽  
MAAGED A. AKIEL ◽  
...  
Keyword(s):  
Staphylococcal Nuclease ◽  
Tudor Domain

scholarly journals The Role of the PRMT5–SND1 Axis in Hepatocellular Carcinoma

Epigenomes ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 2
Author(s):  
Tanner Wright ◽  
Yalong Wang ◽  
Mark T. Bedford
Keyword(s):  
Hepatocellular Carcinoma ◽  
Staphylococcal Nuclease ◽  
Arginine Methylation ◽  
Effector Protein ◽  
Cancer Type ◽  
Post Translational Modification ◽  
Protein Arginine Methyltransferases ◽  
Disease Phenotypes ◽  
Tudor Domain

Arginine methylation is an essential post-translational modification (PTM) deposited by protein arginine methyltransferases (PRMTs) and recognized by Tudor domain-containing proteins. Of the nine mammalian PRMTs, PRMT5 is the primary enzyme responsible for the deposition of symmetric arginine methylation marks in cells. The staphylococcal nuclease and Tudor domain-containing 1 (SND1) effector protein is a key reader of the marks deposited by PRMT5. Both PRMT5 and SND1 are broadly expressed and their deregulation is reported to be associated with a range of disease phenotypes, including cancer. Hepatocellular carcinoma (HCC) is an example of a cancer type that often displays elevated PRMT5 and SND1 levels, and there is evidence that hyperactivation of this axis is oncogenic. Importantly, this pathway can be tempered with small-molecule inhibitors that target PRMT5, offering a therapeutic node for cancer, such as HCC, that display high PRMT5–SND1 axis activity. Here we summarize the known activities of this writer–reader pair, with a focus on their biological roles in HCC. This will help establish a foundation for treating HCC with PRMT5 inhibitors and also identify potential biomarkers that could predict sensitivity to this type of therapy.

Local stability identification and the role of a key aromatic amino acid residue in staphylococcal nuclease refolding

FEBS Journal ◽  
2005 ◽  
Vol 272 (15) ◽  
pp. 3960-3966 ◽  
Author(s):  
Zhengding Su ◽  
Jiun-Ming Wu ◽  
Huey-Jen Fang ◽  
Tian-Yow Tsong ◽  
Hueih-Min Chen
Keyword(s):  
Amino Acid ◽  
Amino Acid Residue ◽  
Aromatic Amino Acid ◽  
Local Stability ◽  
Staphylococcal Nuclease ◽  
Aromatic Amino Acid Residue

scholarly journals 1P-013 The role of the flexible loop in staphylococcal nuclease on its catalytic activity(The 46th Annual Meeting of the Biophysical Society of Japan)

2008 ◽  
Vol 48 (supplement) ◽  
pp. S22
Author(s):  
Shigehumi Tadokoro ◽  
Hironari Kamikubo ◽  
Shigeo Yamaguchi ◽  
Yoichi Yamazaki ◽  
Mikio Kataoka
Keyword(s):  
Catalytic Activity ◽  
Annual Meeting ◽  
Staphylococcal Nuclease ◽  
Flexible Loop ◽  
Biophysical Society

scholarly journals 3M1515 Role of 140Trp on Staphylococcal nuclease for structure

2002 ◽  
Vol 42 (supplement2) ◽  
pp. S193
Author(s):  
S. Hirano ◽  
H. Kamikubo ◽  
Y. Yamazaki ◽  
Y. Imamoto ◽  
M. Kataoka
Keyword(s):  
Staphylococcal Nuclease

scholarly journals 3P019 The role of the flexible loop in Staphylococcal nuclease on its catalytic activity(01A. Protein: Structure,Poster)

2013 ◽  
Vol 53 (supplement1-2) ◽  
pp. S215
Author(s):  
Rumi Shiba ◽  
Hironari Kamikubo ◽  
Yutaka Maruyama ◽  
Junko Yunoki ◽  
Keiichi Fukuyama ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Protein Structure ◽  
Staphylococcal Nuclease ◽  
Flexible Loop

scholarly journals Genetic control of the immune response to staphylococcal nuclease. IV. H-2-linked control of the relative proportions of antibodies produced to different determinants of native nuclease.

1977 ◽  
Vol 145 (1) ◽  
pp. 123-135 ◽  
Author(s):  
J A Berzofsky ◽  
A N Schechter ◽  
G M Shearer ◽  
D H Sachs
Keyword(s):  
Immune Response ◽  
B Cells ◽  
Antibody Response ◽  
Binding Capacity ◽  
Staphylococcal Nuclease ◽  
Gene Control ◽  
Low Responder ◽  
Selection Of ◽  
Ir Genes

The relative proportions of antibodies of different specificities within antisera raised to native staphylococcal nuclease have been studied in several strains of mice in which the antibody response has been shown to be under H-2-linked Ir-gene control. A method was developed in which binding to different radiolabeled fragments of nuclease was titrated against increasing fragment concentration until the binding capacity of the antiserum for that fragment was saturated. In comparing the low responder (H-2b) strain C57BL/10 with its congenic high responder counterpart B10.A (H-2a), it was found that the two strains made markedly and reproducibly different proportions of antibodies to different determinants on native nuclease. Since these two strains differ only at H-2, and therefore have identical immunoglobulin structural gene repertoires, we conclude that H-2-linked Ir genes can control the response to different determinants on the same antigen molecule independently of one another. This result suggests a possible role of H-2-linked genes in the selection of specific B cells.

scholarly journals 1P-089 Role of Luecine 108 for the folding of Staphylococcal Nuclease(The 46th Annual Meeting of the Biophysical Society of Japan)

2008 ◽  
Vol 48 (supplement) ◽  
pp. S35
Author(s):  
Reine Nakagaki ◽  
Hironari Kamikubo ◽  
Yoichi Yamazaki ◽  
Mikio Kataoka
Keyword(s):  
Annual Meeting ◽  
Staphylococcal Nuclease ◽  
Biophysical Society

scholarly journals Local stability identification and the role of key acidic amino acid residues in staphylococcal nuclease unfolding

FEBS Journal ◽  
2005 ◽  
Vol 272 (15) ◽  
pp. 3967-3974 ◽  
Author(s):  
Hueih-Min Chen ◽  
Siu-Chiu Chan ◽  
King-Wong Leung ◽  
Jiun-Ming Wu ◽  
Huey-Jen Fang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Local Stability ◽  
Staphylococcal Nuclease ◽  
Amino Acid Residues ◽  
Acidic Amino Acid

scholarly journals Staphylococcal Nuclease and Tudor Domain Containing 1 (SND1 Protein) Promotes Hepatocarcinogenesis by Inhibiting Monoglyceride Lipase (MGLL)

2016 ◽  
Vol 291 (20) ◽  
pp. 10736-10746 ◽  
Author(s):  
Devaraja Rajasekaran ◽  
Nidhi Jariwala ◽  
Rachel G. Mendoza ◽  
Chadia L. Robertson ◽  
Maaged A. Akiel ◽  
...  
Keyword(s):  
Staphylococcal Nuclease ◽  
Monoglyceride Lipase ◽  
Tudor Domain
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