scholarly journals 3M1515 Role of 140Trp on Staphylococcal nuclease for structure

2002 ◽  
Vol 42 (supplement2) ◽  
pp. S193
Author(s):  
S. Hirano ◽  
H. Kamikubo ◽  
Y. Yamazaki ◽  
Y. Imamoto ◽  
M. Kataoka
Keyword(s):  
Staphylococcal Nuclease

Local stability identification and the role of a key aromatic amino acid residue in staphylococcal nuclease refolding

FEBS Journal ◽  
2005 ◽  
Vol 272 (15) ◽  
pp. 3960-3966 ◽  
Author(s):  
Zhengding Su ◽  
Jiun-Ming Wu ◽  
Huey-Jen Fang ◽  
Tian-Yow Tsong ◽  
Hueih-Min Chen
Keyword(s):  
Amino Acid ◽  
Amino Acid Residue ◽  
Aromatic Amino Acid ◽  
Local Stability ◽  
Staphylococcal Nuclease ◽  
Aromatic Amino Acid Residue

scholarly journals 1P-013 The role of the flexible loop in staphylococcal nuclease on its catalytic activity(The 46th Annual Meeting of the Biophysical Society of Japan)

2008 ◽  
Vol 48 (supplement) ◽  
pp. S22
Author(s):  
Shigehumi Tadokoro ◽  
Hironari Kamikubo ◽  
Shigeo Yamaguchi ◽  
Yoichi Yamazaki ◽  
Mikio Kataoka
Keyword(s):  
Catalytic Activity ◽  
Annual Meeting ◽  
Staphylococcal Nuclease ◽  
Flexible Loop ◽  
Biophysical Society

scholarly journals 3P019 The role of the flexible loop in Staphylococcal nuclease on its catalytic activity(01A. Protein: Structure,Poster)

2013 ◽  
Vol 53 (supplement1-2) ◽  
pp. S215
Author(s):  
Rumi Shiba ◽  
Hironari Kamikubo ◽  
Yutaka Maruyama ◽  
Junko Yunoki ◽  
Keiichi Fukuyama ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Protein Structure ◽  
Staphylococcal Nuclease ◽  
Flexible Loop

scholarly journals Genetic control of the immune response to staphylococcal nuclease. IV. H-2-linked control of the relative proportions of antibodies produced to different determinants of native nuclease.

1977 ◽  
Vol 145 (1) ◽  
pp. 123-135 ◽  
Author(s):  
J A Berzofsky ◽  
A N Schechter ◽  
G M Shearer ◽  
D H Sachs
Keyword(s):  
Immune Response ◽  
B Cells ◽  
Antibody Response ◽  
Binding Capacity ◽  
Staphylococcal Nuclease ◽  
Gene Control ◽  
Low Responder ◽  
Selection Of ◽  
Ir Genes

The relative proportions of antibodies of different specificities within antisera raised to native staphylococcal nuclease have been studied in several strains of mice in which the antibody response has been shown to be under H-2-linked Ir-gene control. A method was developed in which binding to different radiolabeled fragments of nuclease was titrated against increasing fragment concentration until the binding capacity of the antiserum for that fragment was saturated. In comparing the low responder (H-2b) strain C57BL/10 with its congenic high responder counterpart B10.A (H-2a), it was found that the two strains made markedly and reproducibly different proportions of antibodies to different determinants on native nuclease. Since these two strains differ only at H-2, and therefore have identical immunoglobulin structural gene repertoires, we conclude that H-2-linked Ir genes can control the response to different determinants on the same antigen molecule independently of one another. This result suggests a possible role of H-2-linked genes in the selection of specific B cells.

scholarly journals 1P-089 Role of Luecine 108 for the folding of Staphylococcal Nuclease(The 46th Annual Meeting of the Biophysical Society of Japan)

2008 ◽  
Vol 48 (supplement) ◽  
pp. S35
Author(s):  
Reine Nakagaki ◽  
Hironari Kamikubo ◽  
Yoichi Yamazaki ◽  
Mikio Kataoka
Keyword(s):  
Annual Meeting ◽  
Staphylococcal Nuclease ◽  
Biophysical Society

scholarly journals Local stability identification and the role of key acidic amino acid residues in staphylococcal nuclease unfolding

FEBS Journal ◽  
2005 ◽  
Vol 272 (15) ◽  
pp. 3967-3974 ◽  
Author(s):  
Hueih-Min Chen ◽  
Siu-Chiu Chan ◽  
King-Wong Leung ◽  
Jiun-Ming Wu ◽  
Huey-Jen Fang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Local Stability ◽  
Staphylococcal Nuclease ◽  
Amino Acid Residues ◽  
Acidic Amino Acid

scholarly journals Role of the staphylococcal nuclease and tudor domain containing 1 in oncogenesis (Review)

2014 ◽  
Vol 46 (2) ◽  
pp. 465-473 ◽  
Author(s):  
NIDHI JARIWALA ◽  
DEVARAJA RAJASEKARAN ◽  
JYOTI SRIVASTAVA ◽  
RACHEL GREDLER ◽  
MAAGED A. AKIEL ◽  
...  
Keyword(s):  
Staphylococcal Nuclease ◽  
Tudor Domain

A pan-cancer analysis of the oncogenic role of staphylococcal nuclease domain-containing protein 1 (SND1) in human tumors

Genomics ◽  
2020 ◽  
Vol 112 (6) ◽  
pp. 3958-3967 ◽  
Author(s):  
Xiaoteng Cui ◽  
Xinxin Zhang ◽  
Minghui Liu ◽  
Chunyan Zhao ◽  
Nan Zhang ◽  
...  
Keyword(s):  
Staphylococcal Nuclease ◽  
Human Tumors ◽  
Nuclease Domain ◽  
Pan Cancer

scholarly journals Genetic control of the immune response to staphylococcal nuclease. VII. Role of non-H-2-linked genes in the control of the anti-nuclease antibody response

1978 ◽  
Vol 147 (2) ◽  
pp. 396-408 ◽  
Author(s):  
DS Pisetsky ◽  
JA Berzofsky ◽  
DH Sachs
Keyword(s):  
Immune Response ◽  
Antibody Response ◽  
Genetic Control ◽  
Heavy Chain ◽  
Staphylococcal Nuclease ◽  
Antigenic Determinants ◽  
Structural Genes ◽  
Antibody Titers ◽  
Freund's Adjuvant

The role of non-H-2-linked genes in the control of the antibody response to staphylococcal nuclease has been investigated. 3 wk after immunization with nuclease in complete Freund's adjuvant, strain A/J (H-2 a) mice produced significantly higher titers of antibody than strain B10.A (H-2(a)) mice, whereas mice of strains A.BY (H-2(b)) and B10 (H-2(b)) produced barely detectable titers. With hyperimmunization, A/J and A.BY mice reached the same peak levels for antibody titers, both severalfold higher than those reached by B10.A and B10 mice. Analysis of the specificity of antibodies by assessment of binding to two fragments of nuclease showed similarities between strains of the same H-2 haplotype. These results suggest that although H-2-1inked genes determined initial responsiveness at 3 wk and the relative proportions of antibodies directed toward different antigenic determinants on the nuclease molecule, non-H-2-linked genes determined the overall magnitude of the hyperimmuneresponse. Measurement of the affinity of the antibodies to the nuclease fragment (1-126) showed that strains B10 and B10.A produced antibodies with 7- to 10-fold higher affinity than comparable antibodies from strains A.BY and A/J. In a backcross of (B10.A × A/J) × B10.A, the level of antibody segregated independently of the Ig-1(e) C(H) allotype and the A/J anti-nuclease idiotypes. Thus, a gene(s) linked to neither H-2 nor heavy chain structural genes appears to control the aggregate response to antigenic determinants on the nuclease molecule independent of subspecificities of these antibodies or their idiotype.

The role of tryptophan in staphylococcal nuclease stability

2010 ◽  
Vol 151 (3) ◽  
pp. 170-177 ◽  
Author(s):  
Hong-Yu Hu ◽  
Ming-Chya Wu ◽  
Huey-Jen Fang ◽  
Michael D. Forrest ◽  
Chin-Kun Hu ◽  
...  
Keyword(s):  
Staphylococcal Nuclease
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