scholarly journals Pharmacologic inhibition of bone resorption prevents cancer-induced osteolysis but enhances soft tissue metastasis in a mouse model of osteolytic breast cancer

2014 ◽  
Vol 45 (2) ◽  
pp. 532-540 ◽  
Author(s):  
IRENE ZINONOS ◽  
KE-WANG LUO ◽  
AGATHA LABRINIDIS ◽  
VASILIOS LIAPIS ◽  
SHELLEY HAY ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Soft Tissue ◽  
Bone Resorption ◽  
Mouse Model ◽  
Soft Tissue Metastasis ◽  
Pharmacologic Inhibition

scholarly journals Bevacizumab Inhibits Breast Cancer-Induced Osteolysis, Surrounding Soft Tissue Metastasis, and Angiogenesis in Rats as Visualized by VCT and MRI

Neoplasia ◽  
2008 ◽  
Vol 10 (5) ◽  
pp. 511-520 ◽  
Author(s):  
Tobias Bäuerle ◽  
Heidegard Hilbig ◽  
Sönke Bartling ◽  
Fabian Kiessling ◽  
Astrid Kersten ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Soft Tissue ◽  
Soft Tissue Metastasis ◽  
Surrounding Soft Tissue

Bone resorption increases tumour growth in a mouse model of osteosclerotic breast cancer metastasis

2008 ◽  
Vol 25 (5) ◽  
pp. 559-567 ◽  
Author(s):  
Yu Zheng ◽  
Hong Zhou ◽  
Colette Fong-Yee ◽  
James R. K. Modzelewski ◽  
Markus J. Seibel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Resorption ◽  
Mouse Model ◽  
Tumour Growth ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis

Aging, Breast Cancer, and the Mouse Model

2003 ◽  
Author(s):  
Simona Parrinello ◽  
Judith Campisi
Keyword(s):  
Breast Cancer ◽  
Mouse Model

scholarly journals Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Vidya C. Sinha ◽  
Amanda L. Rinkenbaugh ◽  
Mingchu Xu ◽  
Xinhui Zhou ◽  
Xiaomei Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Mouse Model ◽  
Transition State ◽  
Tumor Cell ◽  
Single Cell ◽  
Tumor Cells ◽  
Breast Lesions ◽  
Aggressive Tumor ◽  
Insight Into

AbstractThere is an unmet clinical need for stratification of breast lesions as indolent or aggressive to tailor treatment. Here, single-cell transcriptomics and multiparametric imaging applied to a mouse model of breast cancer reveals that the aggressive tumor niche is characterized by an expanded basal-like population, specialization of tumor subpopulations, and mixed-lineage tumor cells potentially serving as a transition state between luminal and basal phenotypes. Despite vast tumor cell-intrinsic differences, aggressive and indolent tumor cells are functionally indistinguishable once isolated from their local niche, suggesting a role for non-tumor collaborators in determining aggressiveness. Aggressive lesions harbor fewer total but more suppressed-like T cells, and elevated tumor-promoting neutrophils and IL-17 signaling, disruption of which increase tumor latency and reduce the number of aggressive lesions. Our study provides insight into tumor-immune features distinguishing indolent from aggressive lesions, identifies heterogeneous populations comprising these lesions, and supports a role for IL-17 signaling in aggressive progression.

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