scholarly journals Honokiol inhibits U87MG human glioblastoma cell invasion through endothelial cells by regulating membrane permeability and the epithelial-mesenchymal transition

2013 ◽  
Vol 44 (1) ◽  
pp. 187-194 ◽  
Author(s):  
YOUNG NAK JOO ◽  
SO YOUNG EUN ◽  
SANG WON PARK ◽  
JAE HEUN LEE ◽  
KI CHURL CHANG ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Membrane Permeability ◽  
Cell Invasion ◽  
Epithelial Mesenchymal Transition ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Mesenchymal Transition ◽  
Human Glioblastoma Cell

DRR1 promotes glioblastoma cell invasion and epithelial-mesenchymal transition via regulating AKT activation

2018 ◽  
Vol 423 ◽  
pp. 86-94 ◽  
Author(s):  
Yu-Shui Ma ◽  
Zhi-Jun Wu ◽  
Rui-Zhen Bai ◽  
Hua Dong ◽  
Bing-Xue Xie ◽  
...  
Keyword(s):  
Cell Invasion ◽  
Epithelial Mesenchymal Transition ◽  
Glioblastoma Cell ◽  
Mesenchymal Transition ◽  
Akt Activation

CXCL12-induced upregulation of FOXM1 expression promotes human glioblastoma cell invasion

2014 ◽  
Vol 447 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Shengwen Wang ◽  
Shanyi Zhang ◽  
Junliang Li ◽  
Xinke Xu ◽  
Yinlun Weng ◽  
...  
Keyword(s):  
Cell Invasion ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell ◽  
Foxm1 Expression

scholarly journals Inhibition of human glioblastoma cell invasion involves PION@E6 mediated autophagy process

2019 ◽  
Vol Volume 11 ◽  
pp. 2643-2652 ◽  
Author(s):  
Zhongyu Ren ◽  
Jing Liang ◽  
Peng Zhang ◽  
Jianjiao Chen ◽  
Jian Wen
Keyword(s):  
Cell Invasion ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell

FOTEMUSTINE EFFECT ON HUMAN GLIOBLASTOMA CELL LINES

Tsitologiya ◽  
2018 ◽  
Vol 60 (1) ◽  
Author(s):  
L. N. Kiseleva ◽  
◽  
A. V. Kartashev ◽  
N. L. Vartanyan ◽  
A. A. Pinevich ◽  
...  
Keyword(s):  
Cell Lines ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell ◽  
Glioblastoma Cell Lines

scholarly journals Enhanced Anti-Tumor Activity in Mice with Temozolomide-Resistant Human Glioblastoma Cell Line-Derived Xenograft Using SN-38-Incorporated Polymeric Microparticle

2021 ◽  
Vol 22 (11) ◽  
pp. 5557
Author(s):  
Tao-Chieh Yang ◽  
Shih-Jung Liu ◽  
Wei-Lun Lo ◽  
Shu-Mei Chen ◽  
Ya-Ling Tang ◽  
...  
Keyword(s):  
Cell Line ◽  
Therapeutic Index ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell Line ◽  
Human Glioblastoma Cell ◽  
Therapeutic Benefits ◽  
Biodegradable Poly ◽  
Anti Tumor Activity

Glioblastoma multiforme (GBM) has remained one of the most lethal and challenging cancers to treat. Previous studies have shown encouraging results when irinotecan was used in combination with temozolomide (TMZ) for treating GBM. However, irinotecan has a narrow therapeutic index: a slight dose increase in irinotecan can induce toxicities that outweigh its therapeutic benefits. SN-38 is the active metabolite of irinotecan that accounts for both its anti-tumor efficacy and toxicity. In our previous paper, we showed that SN-38 embedded into 50:50 biodegradable poly[(d,l)-lactide-co-glycolide] (PLGA) microparticles (SMPs) provides an efficient delivery and sustained release of SN-38 from SMPs in the brain tissues of rats. These properties of SMPs give them potential for therapeutic application due to their high efficacy and low toxicity. In this study, we tested the anti-tumor activity of SMP-based interstitial chemotherapy combined with TMZ using TMZ-resistant human glioblastoma cell line-derived xenograft models. Our data suggest that treatment in which SMPs are combined with TMZ reduces tumor growth and extends survival in mice bearing xenograft tumors derived from both TMZ-resistant and TMZ-sensitive human glioblastoma cell lines. Our findings demonstrate that combining SMPs with TMZ may have potential as a promising strategy for the treatment of GBM.

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