scholarly journals Kukoamine A inhibits human glioblastoma cell growth and migration through apoptosis induction and epithelial-mesenchymal transition attenuation

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Qiaoping Wang ◽  
Haiyan Li ◽  
Zhen Sun ◽  
Lihua Dong ◽  
Ling Gao ◽  
...  
Keyword(s):  
Cell Growth ◽  
Epithelial Mesenchymal Transition ◽  
Glioblastoma Cell ◽  
Apoptosis Induction ◽  
Cell Growth And Migration ◽  
Human Glioblastoma ◽  
Mesenchymal Transition ◽  
Human Glioblastoma Cell ◽  
And Migration

Enhanced LINC01061 Levels as a Serum Biomarker in Gastric Cancer and Promotion of Malignant Transformation

2021 ◽  
Vol 44 (5) ◽  
pp. 242-251
Author(s):  
Wei Liang ◽  
Bin Xia ◽  
Meina Yan ◽  
Guanghua Zhai ◽  
Meifen Li
Keyword(s):  
Gastric Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Epithelial Mesenchymal Transition ◽  
Growth Curves ◽  
Functional Study ◽  
Cell Growth And Migration ◽  
Mesenchymal Transition ◽  
Qrt Pcr ◽  
And Migration

<b><i>Background:</i></b> The genomic copy number of LINC01061 is amplified in papillary thyroid cancer. However, its role in gastric cancer is not clear. <b><i>Materials and Methods:</i></b> Tissues and serum of GC patients were collected to detect the expression of LINC01061 by quantitative real-time polymerase chain reaction (qRT-PCR). ShRNA were applied to knock down the expression of LINC01061. Growth curves and colony formation experiments were applied to evaluate cell growth. Cell migration was assessed by transwell migration experiments. Cell cycle and apoptosis were analyzed by flow cytometry. Epithelial-mesenchymal transition (EMT) was examined by qRT-PCR and Western blot. <b><i>Results:</i></b> The expression of LINC01061 was upregulated in tissues and serum of GC patients and it was associated with the clinicopathological features and survival time. Functional study indicated that cell growth and migration were suppressed after LINC01061 knockdown. Cell cycle arrest and increased apoptosis occurred when LINC01061 expression was inhibited. EMT was also impaired combined with a decrease in β-catenin expression after LINC01061 knockdown. <b><i>Conclusions:</i></b> Our data indicate that LINC01061 is a novel biomarker for diagnosis and prognosis of GC. LINC01061 promoted progression of GC through cell cycle regulation and EMT.

scholarly journals Anticancer Non-narcotic Opium Alkaloid Papaverine Suppresses Human Glioblastoma Cell Growth

2019 ◽  
Vol 39 (12) ◽  
pp. 6743-6750 ◽  
Author(s):  
MANA INADA ◽  
AKIRA SATO ◽  
MIKA SHINDO ◽  
YOHEI YAMAMOTO ◽  
YASUHARU AKASAKI ◽  
...  
Keyword(s):  
Cell Growth ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell ◽  
Opium Alkaloid

scholarly journals Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth

2013 ◽  
Vol 34 (7) ◽  
pp. 930-938 ◽  
Author(s):  
Qi Qi ◽  
Xia Liu ◽  
Shiyong Li ◽  
Harish C Joshi ◽  
Keqiang Ye
Keyword(s):  
Cell Growth ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell

IGF-II mRNA expression in LI human glioblastoma cell line parallels cell growth

1992 ◽  
Vol 144 (1-2) ◽  
pp. 25-28 ◽  
Author(s):  
Gennaro Melino ◽  
Anastasis Stephanou ◽  
Margherita Annicchiarico-Petruzzelli ◽  
Alessandro Finazzi-Agró ◽  
Richard A. Knight ◽  
...  
Keyword(s):  
Cell Growth ◽  
Mrna Expression ◽  
Cell Line ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell Line ◽  
Human Glioblastoma Cell

scholarly journals Radixin Knockdown by RNA Interference Suppresses Human Glioblastoma Cell Growth in Vitro and in Vivo

2014 ◽  
Vol 15 (22) ◽  
pp. 9805-9812 ◽  
Author(s):  
Jun-Jie Qin ◽  
Jun-Mei Wang ◽  
Jiang Du ◽  
Chun Zeng ◽  
Wu Han ◽  
...  
Keyword(s):  
Rna Interference ◽  
Cell Growth ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell
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