scholarly journals Metabolic profiles of adipose-derived and bone marrow-derived stromal cells from elderly coronary heart disease patients by capillary liquid chromatography quadrupole time-of-flight mass spectrometry

2017 ◽  
Author(s):  
Jian-Zhong Li ◽  
Hui Qu ◽  
Jian Wu ◽  
Fan Zhang ◽  
Zhi-Bo Jia ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Bone Marrow ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Liquid Chromatography ◽  
Stromal Cells ◽  
Capillary Liquid Chromatography ◽  
Metabolic Profiles ◽  
Flight Mass Spectrometry ◽  
Capillary Liquid

scholarly journals A Metabonomics Profiling Study on Phlegm Syndrome and Blood-Stasis Syndrome in Coronary Heart Disease Patients Using Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Linlin Zhao ◽  
Ling Wan ◽  
Xinjian Qiu ◽  
Ruomeng Li ◽  
Shimi Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Liquid Chromatography ◽  
Acid Metabolism ◽  
Blood Stasis ◽  
Blood Stasis Syndrome ◽  
Flight Mass Spectrometry ◽  
Potential Biomarkers ◽  
Phlegm Syndrome

A metabonomics approach based on liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS) was utilized to obtain potential biomarkers of coronary heart disease (CHD) patients and investigate the ZHENG types differentiation in CHD patients. The plasma samples of 20 CHD patients with phlegm syndrome, 20 CHD patients with blood-stasis syndrome, and 16 healthy volunteers were collected in the study. 26 potential biomarkers were identified in the plasma of CHD patients and 19 differential metabolites contributed to the discrimination of phlegm syndrome and blood-stasis syndrome in CHD patients(VIP>1.5; P<0.05)which mainly involved purine metabolism, pyrimidine metabolism, amino acid metabolism, steroid biosynthesis, and arachidonic acid metabolism. This study demonstrated that metabonomics approach based on LC-MS was useful for studying pathologic changes of CHD patients and interpreting the differentiation of ZHENG types (phlegm and blood-stasis syndrome) in traditional Chinese medicine (TCM).

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