scholarly journals A high-throughput and untargeted lipidomics approach reveals new mechanistic insight and the effects of salvianolic acid B on the metabolic profiles in coronary heart disease rats using ultra-performance liquid chromatography with mass spectrometry

RSC Advances ◽  
2020 ◽  
Vol 10 (29) ◽  
pp. 17101-17113
Author(s):  
Ying-peng Li ◽  
Cong-ying Wang ◽  
Hong-tao Shang ◽  
Rui-rui Hu ◽  
Hui Fu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Liquid Chromatography ◽  
High Throughput ◽  
Ultra Performance Liquid Chromatography ◽  
Salvianolic Acid B ◽  
Metabolic Profiles ◽  
Therapeutic Drugs ◽  
Mechanistic Insight

High-throughput lipidomics provides the possibility for the development of new therapeutic drugs.

scholarly journals Lipidomic characterisation discovery for coronary heart disease diagnosis based on high-throughput ultra-performance liquid chromatography and mass spectrometry

RSC Advances ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. 647-654 ◽  
Author(s):  
Chang Liu ◽  
Wen-jing Zong ◽  
Ai-hua Zhang ◽  
Hua-min Zhang ◽  
Yi-han Luan ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Liquid Chromatography ◽  
High Throughput ◽  
Disease Diagnosis ◽  
Ultra Performance Liquid Chromatography ◽  
Diagnostic Tools ◽  
Heart Disease Diagnosis

Although many diagnostic tools have been developed for coronary heart disease (CHD), its diagnosis is still challenging.

scholarly journals High throughput metabolomics-proteomics investigation on metabolic phenotype changes in rats caused byRadix Scrophulariaeusing ultra-performance liquid chromatography with mass spectrometry

RSC Advances ◽  
2019 ◽  
Vol 9 (31) ◽  
pp. 17791-17800
Author(s):  
Fang Lu ◽  
Ning Zhang ◽  
Tao Ye ◽  
Hongwei Zhao ◽  
Mu Pang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
High Throughput ◽  
Chinese Herb ◽  
Ultra Performance Liquid Chromatography ◽  
Metabolic Phenotype ◽  
Hacat Cells ◽  
Traditional Chinese Herb ◽  
Induced Apoptosis

Radix Scrophulariae, a traditional Chinese herb, is used to treat various diseases, including H2O2-induced apoptosis in cardiomyocytes, HaCaT cells, hyperuricaemia, and depression.

scholarly journals A Metabonomics Profiling Study on Phlegm Syndrome and Blood-Stasis Syndrome in Coronary Heart Disease Patients Using Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Linlin Zhao ◽  
Ling Wan ◽  
Xinjian Qiu ◽  
Ruomeng Li ◽  
Shimi Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Liquid Chromatography ◽  
Acid Metabolism ◽  
Blood Stasis ◽  
Blood Stasis Syndrome ◽  
Flight Mass Spectrometry ◽  
Potential Biomarkers ◽  
Phlegm Syndrome

A metabonomics approach based on liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS) was utilized to obtain potential biomarkers of coronary heart disease (CHD) patients and investigate the ZHENG types differentiation in CHD patients. The plasma samples of 20 CHD patients with phlegm syndrome, 20 CHD patients with blood-stasis syndrome, and 16 healthy volunteers were collected in the study. 26 potential biomarkers were identified in the plasma of CHD patients and 19 differential metabolites contributed to the discrimination of phlegm syndrome and blood-stasis syndrome in CHD patients(VIP>1.5; P<0.05)which mainly involved purine metabolism, pyrimidine metabolism, amino acid metabolism, steroid biosynthesis, and arachidonic acid metabolism. This study demonstrated that metabonomics approach based on LC-MS was useful for studying pathologic changes of CHD patients and interpreting the differentiation of ZHENG types (phlegm and blood-stasis syndrome) in traditional Chinese medicine (TCM).

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