scholarly journals Shikonin reduces TGF-β1-induced collagen production and contraction in hypertrophic scar-derived human skin fibroblasts

2015 ◽  
Vol 36 (4) ◽  
pp. 985-991 ◽  
Author(s):  
CHEN FAN ◽  
YING DONG ◽  
YAN XIE ◽  
YONGHUA SU ◽  
XUFANG ZHANG ◽  
...  
Keyword(s):  
Human Skin ◽  
Hypertrophic Scar ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Collagen Production ◽  
Tgf Β1

scholarly journals Changes in the synthesis, distribution and sulphation of glycosaminoglycans of cultured human skin fibroblasts upon ascorbate feeding

1983 ◽  
Vol 64 (1) ◽  
pp. 245-254
Author(s):  
M. Edward ◽  
R.F. Oliver
Keyword(s):  
Ascorbic Acid ◽  
Cell Density ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Collagen Production ◽  
Sulphated Glycosaminoglycans ◽  
Cell Fractions

The effect of ascorbic acid on the synthesis, distribution and sulphation of glycosaminoglycans by human skin fibroblasts has been examined. Medium was supplemented with ascorbate over several days, and cultures incubated with [3H]glucosamine and Na2(35)SO4 for 48 h, followed by analysis of the glycosaminoglycans in the medium, in collagenase and trypsin extracts, and in cell fractions. Ascorbate feeding resulted in a reduction in hyaluronate synthesis, which was the main 3H-labelled component and was distributed mainly in the medium fractions. Sulphated glycosaminoglycans showed a reduction in incorporation of 3H label, but increased sulphation following ascorbate feeding. In control cultures 53% of 3H-labelled sulphated glycosaminoglycans and 63% of 35S-labelled glycosaminoglycans were present in the medium fraction, while in ascorbate-fed cultures, 41% of 3H label and 38% 35S label were incorporated into medium-sulphated glycosaminoglycans. Ascorbate also caused an increase in cell density and in collagen production and deposition.

Royal Jelly Protects Against Ultraviolet B–Induced Photoaging in Human Skin Fibroblasts via Enhancing Collagen Production

2011 ◽  
Vol 14 (9) ◽  
pp. 899-906 ◽  
Author(s):  
Hye Min Park ◽  
Eunson Hwang ◽  
Kwang Gill Lee ◽  
Sang-Mi Han ◽  
Yunhi Cho ◽  
...  
Keyword(s):  
Human Skin ◽  
Royal Jelly ◽  
Ultraviolet B ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Collagen Production

TGF-β1 mediates 70-kDa heat shock protein induction due to ultraviolet irradiation in human skin fibroblasts

1999 ◽  
Vol 438 (3) ◽  
pp. 239-244 ◽  
Author(s):  
Y. Cao ◽  
Nobu Ohwatari ◽  
Takaaki Matsumoto ◽  
M. Kosaka ◽  
Akira Ohtsuru ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Human Skin ◽  
Ultraviolet Irradiation ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Tgf Β1
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