scholarly journals Kaempferol suppresses lipid accumulation in macrophages through the downregulation of cluster of differentiation 36 and the upregulation of scavenger receptor class B type I and ATP-binding cassette transporters A1 and G1

2012 ◽  
Vol 31 (2) ◽  
pp. 331-338 ◽  
Author(s):  
XIU-YING LI ◽  
LING-XI KONG ◽  
JUAN LI ◽  
HAI-XIA HE ◽  
YUAN-DA ZHOU
Keyword(s):  
Lipid Accumulation ◽  
Scavenger Receptor ◽  
Atp Binding ◽  
Type I ◽  
Scavenger Receptor Class ◽  
Atp Binding Cassette Transporters ◽  
Class B ◽  
Cluster Of Differentiation ◽  
Atp Binding Cassette

Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice

Hepatology ◽  
2009 ◽  
Vol 50 (4) ◽  
pp. 1263-1272 ◽  
Author(s):  
Harmen Wiersma ◽  
Alberto Gatti ◽  
Niels Nijstad ◽  
Ronald P. J. Oude Elferink ◽  
Folkert Kuipers ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Atp Binding ◽  
Type I ◽  
Biliary Cholesterol ◽  
Atp Binding Cassette Transporter ◽  
Scavenger Receptor Class ◽  
Class B ◽  
Biliary Cholesterol Secretion ◽  
Cholesterol Secretion ◽  
Atp Binding Cassette

scholarly journals Reduced Plasma High-Density Lipoprotein Cholesterol in Hyperthyroid Mice Coincides with Decreased Hepatic Adenosine 5′-Triphosphate-Binding Cassette Transporter 1 Expression

Endocrinology ◽  
2008 ◽  
Vol 149 (7) ◽  
pp. 3708-3712 ◽  
Author(s):  
Ivan Tancevski ◽  
Andreas Wehinger ◽  
Egon Demetz ◽  
Philipp Eller ◽  
Kristina Duwensee ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Atp Binding ◽  
Type I ◽  
Hepatic Expression ◽  
Atp Binding Cassette Transporter ◽  
Scavenger Receptor Class ◽  
Class B ◽  
Plasma High Density ◽  
Atp Binding Cassette

The aim of the study was to investigate the influence of severe hyperthyroidism on plasma high-density lipoprotein cholesterol (HDL-C). Recently, it was shown in mice that increasing doses of T3 up-regulate hepatic expression of scavenger receptor class B, type I, resulting in increased clearance of plasma HDL-C. Here, we show that severe hyperthyroidism in mice did not affect hepatic expression of scavenger receptor class B, type I, but reduced hepatic expression of ATP-binding cassette transporter 1, accompanied by a 40% reduction of HDL-C. The sterol content of bile, liver, and feces was markedly increased, accompanied by up-regulation of hepatic cholesterol 7α-hydroxylase, and ATP-binding cassette transporter 5, which is known to promote biliary sterol secretion upon dimerization with ATP-binding cassette transporter 8. Both control and hyperthyroid mice exerted identical plasma clearance of iv injected [3H]HDL-C, supporting the view that severe hyperthyroidism does not affect HDL-C clearance but, rather, its formation via hepatic ATP-binding cassette transporter 1.

scholarly journals HDL modification by secretory phospholipase A2 promotes scavenger receptor class B type I interaction and accelerates HDL catabolism

2000 ◽  
Vol 41 (11) ◽  
pp. 1849-1857 ◽  
Author(s):  
Frederick C. de Beer ◽  
Patrice M. Connell ◽  
J. Yu ◽  
Maria C. de Beer ◽  
Nancy R. Webb ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Scavenger Receptor ◽  
Type I ◽  
Secretory Phospholipase A2 ◽  
Secretory Phospholipase ◽  
Scavenger Receptor Class ◽  
Class B

MS81 LIVER-SPECIFIC LIPOPLEXES FOR THE KNOCKDOWN OF SCAVENGER RECEPTOR CLASS B TYPE I

2010 ◽  
Vol 11 (2) ◽  
pp. 126
Author(s):  
K. Duwensee ◽  
I. Tancevski ◽  
E. Demetz ◽  
P. Eller ◽  
C. Heim ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Type I ◽  
Scavenger Receptor Class ◽  
Class B
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