Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice

Hepatology ◽  
2009 ◽  
Vol 50 (4) ◽  
pp. 1263-1272 ◽  
Author(s):  
Harmen Wiersma ◽  
Alberto Gatti ◽  
Niels Nijstad ◽  
Ronald P. J. Oude Elferink ◽  
Folkert Kuipers ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Atp Binding ◽  
Type I ◽  
Biliary Cholesterol ◽  
Atp Binding Cassette Transporter ◽  
Scavenger Receptor Class ◽  
Class B ◽  
Biliary Cholesterol Secretion ◽  
Cholesterol Secretion ◽  
Atp Binding Cassette

scholarly journals Reduced Plasma High-Density Lipoprotein Cholesterol in Hyperthyroid Mice Coincides with Decreased Hepatic Adenosine 5′-Triphosphate-Binding Cassette Transporter 1 Expression

Endocrinology ◽  
2008 ◽  
Vol 149 (7) ◽  
pp. 3708-3712 ◽  
Author(s):  
Ivan Tancevski ◽  
Andreas Wehinger ◽  
Egon Demetz ◽  
Philipp Eller ◽  
Kristina Duwensee ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Atp Binding ◽  
Type I ◽  
Hepatic Expression ◽  
Atp Binding Cassette Transporter ◽  
Scavenger Receptor Class ◽  
Class B ◽  
Plasma High Density ◽  
Atp Binding Cassette

The aim of the study was to investigate the influence of severe hyperthyroidism on plasma high-density lipoprotein cholesterol (HDL-C). Recently, it was shown in mice that increasing doses of T3 up-regulate hepatic expression of scavenger receptor class B, type I, resulting in increased clearance of plasma HDL-C. Here, we show that severe hyperthyroidism in mice did not affect hepatic expression of scavenger receptor class B, type I, but reduced hepatic expression of ATP-binding cassette transporter 1, accompanied by a 40% reduction of HDL-C. The sterol content of bile, liver, and feces was markedly increased, accompanied by up-regulation of hepatic cholesterol 7α-hydroxylase, and ATP-binding cassette transporter 5, which is known to promote biliary sterol secretion upon dimerization with ATP-binding cassette transporter 8. Both control and hyperthyroid mice exerted identical plasma clearance of iv injected [3H]HDL-C, supporting the view that severe hyperthyroidism does not affect HDL-C clearance but, rather, its formation via hepatic ATP-binding cassette transporter 1.

scholarly journals Effects of Astaxanthin on Reverse Cholesterol Transport and Atherosclerosis in Mice

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Tang-Bin Zou ◽  
Shan-Shan Zhu ◽  
Fei Luo ◽  
Wei-Qiao Li ◽  
Xue-Rong Sun ◽  
...  
Keyword(s):  
Reverse Cholesterol Transport ◽  
Scavenger Receptor ◽  
Hdl Cholesterol ◽  
High Plasma ◽  
Cholesterol Transport ◽  
Atp Binding ◽  
Type I ◽  
Aortic Sinus ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

High plasma level of HDL-cholesterol (HDL-C) has been consistently associated with a decreased risk of atherosclerosis (AS); thus, HDL-C is considered to be an antiatherogenic lipoprotein. The development of novel therapies to enhance the atheroprotective properties of HDL may have the possibility of further reducing the residual AS risk. Reverse cholesterol transport (RCT) is believed to be a primary atheroprotective activity of HDL, which has been shown to promote the efflux of excess cholesterol from macrophage-derived foam cells via ATP-binding cassette transporter A1 (ABCA1), ATP-binding cassette transporter G1 (ABCG1), and scavenger receptor class B type I (SR-BI) and then transport it back to the liver for excretion into bile and eventually into the feces. In the current study, we investigated the effects of astaxanthin on RCT and AS progression in mice. The results showed that short- and long-term supplementation of astaxanthin promote RCT in C57BL/6J and ApoE−/−mice, respectively. Moreover, astaxanthin can relieve the plaque area of the aortic sinus and aortic cholesterol in mice. These findings suggest that astaxanthin is beneficial for boosting RCT and preventing the development of AS.

scholarly journals HDL modification by secretory phospholipase A2 promotes scavenger receptor class B type I interaction and accelerates HDL catabolism

2000 ◽  
Vol 41 (11) ◽  
pp. 1849-1857 ◽  
Author(s):  
Frederick C. de Beer ◽  
Patrice M. Connell ◽  
J. Yu ◽  
Maria C. de Beer ◽  
Nancy R. Webb ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Scavenger Receptor ◽  
Type I ◽  
Secretory Phospholipase A2 ◽  
Secretory Phospholipase ◽  
Scavenger Receptor Class ◽  
Class B

MS81 LIVER-SPECIFIC LIPOPLEXES FOR THE KNOCKDOWN OF SCAVENGER RECEPTOR CLASS B TYPE I

2010 ◽  
Vol 11 (2) ◽  
pp. 126
Author(s):  
K. Duwensee ◽  
I. Tancevski ◽  
E. Demetz ◽  
P. Eller ◽  
C. Heim ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Type I ◽  
Scavenger Receptor Class ◽  
Class B
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