scholarly journals Cisplatin-induced apoptosis in human promyelocytic leukemia cells

2006 ◽  
Author(s):  
Maurizio Previati ◽  
Irene Lanzoni ◽  
Elisa Corbacella ◽  
Sara Magosso ◽  
Valeria Guaran ◽  
...  
Keyword(s):  
Promyelocytic Leukemia ◽  
Leukemia Cells ◽  
Induced Apoptosis

Cisplatin-Induced Apoptosis in HL-60 Human Promyelocytic Leukemia Cells

2003 ◽  
Vol 1010 (1) ◽  
pp. 153-158 ◽  
Author(s):  
KOSTAS V. FLOROS ◽  
HELLINIDA THOMADAKI ◽  
GEORGE LALLAS ◽  
NIKOS KATSAROS ◽  
MAROULIO TALIERI ◽  
...  
Keyword(s):  
Promyelocytic Leukemia ◽  
Leukemia Cells ◽  
Induced Apoptosis

Mechanism of dibucaine-induced apoptosis in promyelocytic leukemia cells (HL-60)

2000 ◽  
Vol 60 (7) ◽  
pp. 905-915 ◽  
Author(s):  
Kayo Arita ◽  
Toshihiko Utsumi ◽  
Akio Kato ◽  
Tomoko Kanno ◽  
Hirotsugu Kobuchi ◽  
...  
Keyword(s):  
Promyelocytic Leukemia ◽  
Leukemia Cells ◽  
Induced Apoptosis

scholarly journals 23-Hydroxyursolic Acid Isolated from the Stem Bark of Cussonia bancoensis Induces Apoptosis through Fas/Caspase-8-Dependent Pathway in HL-60 Human Promyelocytic Leukemia Cells

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3306 ◽  
Author(s):  
Jong-Heon Won ◽  
Kyung-Sook Chung ◽  
Eun-Young Park ◽  
Jeong-Hun Lee ◽  
Jung-Hye Choi ◽  
...  
Keyword(s):  
Dna Fragmentation ◽  
Molecular Mechanisms ◽  
Caspase 3 ◽  
Stem Bark ◽  
Promyelocytic Leukemia ◽  
Leukemia Cells ◽  
Caspase 8 ◽  
Signaling Complex ◽  
Induced Apoptosis ◽  
Apoptotic Effects

The natural product 23-hydroxyursolic acid (23-HUA) is a derivative of ursolic acid, which is known to induce cancer cell apoptosis. However, apoptotic effects and mechanisms of 23-HUA have not been well characterized yet. Herein, we investigated the molecular mechanisms of 23-HUA-induced apoptosis in HL-60 human promyelocytic leukemia cells. 23-HUA-treated HL-60 cells showed apoptotic features including internucleosomal DNA condensation and fragmentation as well as externalization of phosphatidylserine residues. 23-HUA induced a series of mitochondrial events including disruption of mitochondrial membrane potential (ΔΨm), cytochrome c and Smac/DIABLO release and loss of balance between pro-apoptotic and anti-apoptotic Bcl-2 proteins in HL-60 cells. In addition, 23-HUA activated caspase-8, caspase-9 and caspase-3. Pretreatment with a broad caspase inhibitor (z-VAD-fmk), a caspase-3 inhibitor (z-DEVD-fmk), and a caspase-8 inhibitor (z-IETD-fmk) significantly attenuated 23-HUA-induced DNA fragmentation. After 23-HUA-induced apoptosis, proteins expression levels of FasL, Fas and FADD constituting the death-inducing signaling complex (DISC) were upregulated in HL-60 cells. Moreover, transfection with Fas or FADD siRNA significantly blocked 23-HUA-induced DNA fragmentation and caspases activation. Taken together, these findings indicate that 23-HUA induces apoptosis in HL-60 human promyelocytic leukemia cells through formation of DISC and caspase-8 activation leading to loss of ΔΨm and caspase-3 activation.

Mechanism of α-tocopheryl succinate-induced apoptosis of promyelocytic leukemia cells

2000 ◽  
Vol 33 (4) ◽  
pp. 407-418 ◽  
Author(s):  
Shinji Yamamoto ◽  
Hiroshi Tamai ◽  
Rumi Ishisaka ◽  
Tomoko Kanno ◽  
Kayo Arita ◽  
...  
Keyword(s):  
Promyelocytic Leukemia ◽  
Leukemia Cells ◽  
Tocopheryl Succinate ◽  
Induced Apoptosis

Azidothymidine hinders arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells by induction of p21 and attenuation of G2/M arrest

2013 ◽  
Vol 92 (9) ◽  
pp. 1207-1220 ◽  
Author(s):  
Saeed Hassani ◽  
Seyed H. Ghaffari ◽  
Farhad Zaker ◽  
Rohellah Mirzaee ◽  
Hajar Mardani ◽  
...  
Keyword(s):  
Arsenic Trioxide ◽  
Acute Promyelocytic Leukemia ◽  
Promyelocytic Leukemia ◽  
Leukemia Cells ◽  
Induced Apoptosis
Sign in / Sign up

Export Citation Format

Share Document