scholarly journals Dose-dependent effects of selenite (Se4+) on arsenite (As3+)-induced apoptosis and differentiation in acute promyelocytic leukemia cells

2015 ◽  
Vol 6 (1) ◽  
pp. e1596-e1596 ◽  
Author(s):  
S Wang ◽  
Z Geng ◽  
N Shi ◽  
X Li ◽  
Z Wang
Keyword(s):  
Acute Promyelocytic Leukemia ◽  
Promyelocytic Leukemia ◽  
Leukemia Cells ◽  
Induced Apoptosis ◽  
Dose Dependent

Anti-Leukemic Effect of Tetra-Arsenic Oxide in Acute Promyelocytic Leukemia Cells in Vitro and In Vivo

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4306-4306
Author(s):  
So Young Chong ◽  
Moon Ju Jang ◽  
Sun Ju Lee ◽  
Ji Young Huh ◽  
Jeehyeon Bae ◽  
...  
Keyword(s):  
Acute Promyelocytic Leukemia ◽  
Cell Lines ◽  
Xenograft Model ◽  
Promyelocytic Leukemia ◽  
Dependent Manner ◽  
Facs Analysis ◽  
Arsenic Oxide ◽  
Induced Apoptosis ◽  
Dose Dependent

Abstract Abstract 4306 Arsenic trioxide (As2O3; ATO) has been established to be an effective agent for treating acute promyelocytic leukemia (APL). Tetra-arsenic oxide (As4O6; TAO) is a new arsenic compound which has shown anti-proliferative and apoptosis-inducing effects against human leukemic and solid tumor cells, but TAO has never been studied in APL so far. We investigated the effect of TAO in APL cell lines (NB-4), and evaluated their anti-leukemic effect in murine xenograft model. In both the XTT assay and in FACS analysis, TAO inhibited cell proliferation and induced apoptosis in NB4 cell lines as effective as ATO in dose dependent manner. In FACS analysis, TAO induced apoptosis in NB4 cell lines as effective as ATO in a dose dependent manner. However, expression of differentiation (CD11b) was unchanged. For in vivo study, we established a xenograft model in nude mice (BALB/cBy J-nu) using the NB4 cell line. 1 × 107 NB4 cells were inoculated into the flank subcutaneously. When the tumor size reached 1.0 cm3, intra-peritoneal ATO or TAO treatment (5mg/kg or 10mg/kg) was initiated and administration was performed daily. We found that TAO (10mg/kg) significantly inhibited tumor growth of the inoculated NB4 cell as effective as ATO (10mg/kg). These results suggest that TAO may have a potential for the treatment of APL. Disclosures: No relevant conflicts of interest to declare.

Azidothymidine hinders arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells by induction of p21 and attenuation of G2/M arrest

2013 ◽  
Vol 92 (9) ◽  
pp. 1207-1220 ◽  
Author(s):  
Saeed Hassani ◽  
Seyed H. Ghaffari ◽  
Farhad Zaker ◽  
Rohellah Mirzaee ◽  
Hajar Mardani ◽  
...  
Keyword(s):  
Arsenic Trioxide ◽  
Acute Promyelocytic Leukemia ◽  
Promyelocytic Leukemia ◽  
Leukemia Cells ◽  
Induced Apoptosis

scholarly journals Erratum: Arsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells

Leukemia ◽  
2005 ◽  
Vol 19 (2) ◽  
pp. 322-322
Author(s):  
P Lunghi ◽  
A Tabilio ◽  
F Lo-Coco ◽  
P Pelicci ◽  
A Bonati
Keyword(s):  
Arsenic Trioxide ◽  
Acute Promyelocytic Leukemia ◽  
Promyelocytic Leukemia ◽  
Leukemia Cells

Metabolism of Arsenic Trioxide in Acute Promyelocytic Leukemia Cells

2014 ◽  
Vol 115 (10) ◽  
pp. 1729-1739 ◽  
Author(s):  
Ali Khaleghian ◽  
Seyed H. Ghaffari ◽  
Shahin Ahmadian ◽  
Kamran Alimoghaddam ◽  
Ardeshir Ghavamzadeh
Keyword(s):  
Arsenic Trioxide ◽  
Acute Promyelocytic Leukemia ◽  
Promyelocytic Leukemia ◽  
Leukemia Cells
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