Transforming growth factor-β released by PPD-presenting malignant mesothelioma cells inhibits interferon-γ synthesis by an anti-PPD CD4+ T-cell clone

2003 ◽  
Author(s):  
Maria Valle ◽  
Camillo Porta ◽  
Anna Megiovanni ◽  
Roberta Libener ◽  
Laura Mele ◽  
...  
Keyword(s):  
T Cell ◽  
Growth Factor ◽  
Malignant Mesothelioma ◽  
Transforming Growth Factor ◽  
Cell Clone ◽  
Transforming Growth Factor Β ◽  
Interferon Γ ◽  
Cd4 T Cell ◽  
T Cell Clone

scholarly journals Characterization of an I-E-Restricted, gp63-Specific, CD4-T-Cell Clone from Leishmania major-Resistant C3H Mice That Secretes Type 2 Cytokines and Exacerbates Infection with L. major

2004 ◽  
Vol 72 (8) ◽  
pp. 4486-4493
Author(s):  
Cynthia M. Theodos ◽  
Robin V. Morris ◽  
Jeanette V. Bishop ◽  
Jeremy D. Jones ◽  
W. Robert McMaster ◽  
...  
Keyword(s):  
T Cell ◽  
Leishmania Major ◽  
Transforming Growth Factor ◽  
Cell Clone ◽  
Parasite Burden ◽  
Cd4 T Cell ◽  
Amino Terminal ◽  
T Cell Clone ◽  
C3h Mice

ABSTRACT A T-cell clone (designated KLmB-3) was derived from resistant C3H mice 2 weeks after infection with Leishmania major. KLmB-3 was a CD4-T-cell clone that utilized the Vβ8.1 T-cell receptor. When adoptively transferred to naive C3H mice, KLmB-3 unexpectedly exacerbated infection with L. major (it increased the cutaneous lesion size and the parasite burden within the lesion). The ability of KLmB-3 to exacerbate disease correlated with its ability to produce the type 2-associated cytokines interleukin-4 (IL-4), IL-5, IL-10, and transforming growth factor beta. Interestingly, KLmB-3 was specific for an epitope in the amino-terminal end of the L. major surface gp63 zinc metalloproteinase (leishmanolysin) that has been shown to be capable of inducing a protective immune response. Moreover, KLmB-3 was activated when this epitope was presented in the context of H-2 I-E rather than H-2 I-A.

scholarly journals Cell-Intrinsic Transforming Growth Factor-β Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence In Vivo

Immunity ◽  
2009 ◽  
Vol 31 (1) ◽  
pp. 145-157 ◽  
Author(s):  
Roberto Tinoco ◽  
Victor Alcalde ◽  
Yating Yang ◽  
Karsten Sauer ◽  
Elina I. Zuniga
Keyword(s):  
T Cell ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Viral Persistence ◽  
Transforming Growth Factor Β ◽  
Cd8 T Cell ◽  
Cell Deletion

scholarly journals Transfer of protective immunity in murine histoplasmosis by a CD4+ T-cell clone.

1993 ◽  
Vol 61 (2) ◽  
pp. 714-718 ◽  
Author(s):  
R Allendoerfer ◽  
D M Magee ◽  
G S Deepe ◽  
J R Graybill
Keyword(s):  
T Cell ◽  
Protective Immunity ◽  
Cell Clone ◽  
Cd4 T Cell ◽  
T Cell Clone

Tachyzoite-specific isoform of Toxoplasma gondii lactate dehydrogenase is the target antigen of a murine CD4+ T-cell clone

2001 ◽  
Vol 3 (10) ◽  
pp. 779-787 ◽  
Author(s):  
Gaby Reichmann ◽  
Henryka Długońska ◽  
Ela Hiszczyńska-Sawicka ◽  
Hans-Georg Fischer
Keyword(s):  
Lactate Dehydrogenase ◽  
T Cell ◽  
Toxoplasma Gondii ◽  
Cell Clone ◽  
Cd4 T Cell ◽  
Target Antigen ◽  
T Cell Clone
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