scholarly journals No evidence of a correlation between lumbar spinal subtypes and intervertebral disc degeneration among asymptomatic middle‑aged and aged patients

2020 ◽  
Author(s):  
Ben Wang ◽  
Yifeng Shi ◽  
Boda Chen ◽  
Zhenxuan Shao ◽  
Lijie Chen ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Middle Aged ◽  
Aged Patients ◽  
Lumbar Spinal

scholarly journals A New Potential Indicator in Differentiating Patients with Lumbar Spinal Stenosis and Lumbar Intervertebral Disc Degeneration

2021 ◽  
Author(s):  
Faezeh Eskandari ◽  
Shima Bahramizadeh Sajadi ◽  
Hamid Reza Katoozian
Keyword(s):  
Intervertebral Disc ◽  
Spinal Stenosis ◽  
Disc Degeneration ◽  
Lumbar Spinal Stenosis ◽  
Intervertebral Disc Degeneration ◽  
Center Of Pressure ◽  
Intersection Angle ◽  
Lumbar Intervertebral Disc ◽  
Spinal Disorders ◽  
Lumbar Spinal

Background: Center of pressure (CoP) trajectory is one of the gait parameters that is widely used for clinical assessments. Moreover, the CoP trajectory could be adversely affected by anatomic and mechanical factors that involve foot function, which was shown to be correlated with musculoskeletal diseases. The aim of this study is to compare angle-associated parameters of gait in patients with different lumbar spinal disorders. Methods: The subjects suffered from the same levels of spine impairment, including patients with lumbar spinal stenosis (LSS) and lumbar intervertebral disc degeneration (LIDD) were recruited in this study. The spatio-temporal angular parameters associated with the CoP of the subjects during their gait were collected and examined. The measurements were used to calculate the CoP angle and symmetry angle (SA). Then the butterfly diagram (BD) intersection angle was introduced as a new potential parameter in gait assessment. Results: The results of the current study showed that CoPs and SAs did not vary between the two groups (P > 0.05). The BD intersection angle, however, indicated some variations between patients with LSS and LIDD (P < 0.05). Conclusion: While the results showed that CoP angles and SAs did not differ between the LSS and LIDD groups, it is hypothesized that such disorders that affect the gait could be reflected in the BD intersection angle. Therefore, the BD intersection angle is suggested as a clinical indicator in clarifying patients with lumbar spinal disorders.

INTERVERTEBRAL DISC DEGENERATION LINKED TO STRUCTURAL GENE VARIATIONS

2019 ◽  
Author(s):  
Saeeda Baig
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
English Language ◽  
Tandem Repeats ◽  
Lumbar Disc ◽  
Disease Process ◽  
Nucleotide Polymorphisms ◽  
Structural Protein ◽  
Lumbar Disc Degeneration

During the recent past focus has shifted from identifying intervertebral disc degeneration as being caused by physical exposure and strain to being linked with a variety of genetic variations. The objective of this review is to provide an up to date review of the existing research data regarding the relation of intervertebral disc degeneration to structural protein genes and their polymorphisms and thus help clearly establish further avenues where research into causation and treatment is needed. A comprehensive search using the keywords “Collagen”, “COL”, “Aggrecan”, “AGC”, “IVDD”, “intervertebral disc degeneration”, and “lumbar disc degeneration” from PubMed and Google Scholar, where literature in the English language was selected spanning from 1991 to 2019. There are many genes involved in the production of structural components of an intervertebral disc. The issues in production of these components involve the over-expression or under-expression of their genes, and single nucleotide polymorphisms and variable number of tandem repeats affecting their structures. These structural genes include primarily the collagen and the aggrecan genes. While genetic and environmental factors all come into play with a disease process like disc degeneration, the bulk of research now shows the significantly larger impact of hereditary over exposure. While further research is needed into some of the lesser studied genes linked to IVDD and also the racial variations in genetic makeup, the focus in the near future should be on establishment of genetic testing to identify individuals at greater risk of disease and deliberation regarding the use of gene therapy to prevent disc degeneration.

The Caspase-3 Knockout Inhibits Intervertebral Disc Degeneration Related to Injury But Accelerates Degeneration Related to Aging

2019 ◽  
Author(s):  
Takashi Ohnishi ◽  
Katsuhisa Yamada ◽  
Koji Iwasaki ◽  
Takeru Tsujimoto ◽  
Hideaki Higashi ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Caspase 3

Inhibition of LRRK2 Restores Parkin-Mediated Mitophagy and Suppresses Apoptosis in Intervertebral Disc Degeneration

2020 ◽  
Author(s):  
Jialiang Lin ◽  
Xuanqi Zheng ◽  
Zengjie Zhang ◽  
Zhenxuan Shao ◽  
Chongan Huang ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration
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