scholarly journals Cerebellar fastigial nucleus is involved in post‑stroke depression through direct cerebellar‑hypothalamic GABAergic and glutamatergic projections

2019 ◽  
Author(s):  
Yuan Li ◽  
Xin Zhang ◽  
Lixin Chen ◽  
Bo Yang ◽  
Rubo Sui
Keyword(s):  
Fastigial Nucleus ◽  
Post Stroke ◽  
Post Stroke Depression

scholarly journals Cerebellar Fastigial Nucleus Electrical Stimulation Alleviates Depressive-Like Behaviors in Post-Stroke Depression Rat Model and Potential Mechanisms

2017 ◽  
Vol 41 (4) ◽  
pp. 1403-1412 ◽  
Author(s):  
Lei Zhang ◽  
Mingkui Zhao ◽  
Ru-Bo Sui
Keyword(s):  
Weight Loss ◽  
Electrical Stimulation ◽  
Purkinje Cells ◽  
Inflammatory Cytokines ◽  
Rat Model ◽  
Mrna Level ◽  
Fastigial Nucleus ◽  
Post Stroke ◽  
Post Stroke Depression ◽  
Cerebellar Purkinje Cells

Objective: To identify the molecular mechanism of post-stroke depression (PSD), and observe the therapeutic effects of cerebellar fastigial nucleus electrical stimulation (FNS) on the behaviors and regional cerebral blood flow (rCBF) in a PSD rat model. Methods: Healthy SD rats were randomly divided into four groups (sham, stroke, post-stroke depress and FNS group). Sham group (n = 6) underwent sham operation. The other three groups (n = 6*3) underwent MCAO. Rats were examined twice a week in open filed test. Moreover, neuroprotective effect on cerebellar Purkinje cells and expression of cytokines in hippocampal tissue were examined. Results: The PSD group showed a significant weight loss, decreased consumption of sucrose water, reduced rearing and locomotor activities. The FNS significantly alleviates the body weight loss and sucrose preference, locomotor and rearing activities. The bilateral rCBF was also restored after FNS treatment. Moreover, FNS improved the neuroprotection via suppressing apoptosis of cerebellar Purkinje cells. And the inflammatory cytokines mRNA level in hippocampus was significantly decreased. Conclusion: FNS treatment alleviates depressive-like behaviors and rCBF in PSD rats model, which could be attributed to its ability to protect cerebellar Purkinje cells and decrease the mRNA level of inflammatory cytokines.

Early Symptom Measurement of Post‐Stroke Depression

2016 ◽  
Author(s):  
Jufang Li ◽  
Linda Denise Oakley ◽  
Roger L. Brown ◽  
Yun Li ◽  
Maiyun Ye ◽  
...  
Keyword(s):  
Early Symptom ◽  
Post Stroke ◽  
Post Stroke Depression ◽  
Symptom Measurement

Therapy of post-stroke depression – a systematic review

2013 ◽  
Vol 10 (02) ◽  
pp. 108-129 ◽  
Author(s):  
W. Gaebel ◽  
W. Wannagat ◽  
J. Zielasek
Keyword(s):  
Systematic Review ◽  
Large Scale ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Placebo Control ◽  
Post Stroke ◽  
Pharmacological Studies ◽  
Post Stroke Depression ◽  
Control Procedures ◽  
Antidepressant Pharmacotherapy

SummaryWe performed a systematic review of randomized placebo-controlled pharmacological and non-pharmacological trials for the therapy and prevention of post-stroke depression that have been published between 1980 and 2011. We initially identified 2 260 records of which 28 studies were finally included into this review. A meta-analytic approach was hampered by considerable differences regarding the kinds of therapeutic regimens and the study durations. Modest effects favoring treatment of post-stroke depression could be found for pharmacological treatment as well as repetitive transcranial magnetic stimulation. For the prevention of post-stroke depression, antidepressant pharmacotherapy showed promising results. However, large-scale studies with better standardized study populations, optimized placebo control procedures in non-pharmacological studies, and replication in larger follow-up studies are still necessary to find the optimal therapeutic regimens to prevent and treat post-stroke depression.

Influence of informing patients with stroke of environment during hospitalization for the disease post-stroke depression

2015 ◽  
Vol 17 (9) ◽  
pp. 63-65 ◽  
Author(s):  
M.N. Maltseva ◽  
◽  
E.V. Melnikova ◽  
A.A. Shmonin ◽  
I.A. Sudnikova ◽  
...  
Keyword(s):  
Post Stroke ◽  
Post Stroke Depression
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