scholarly journals Anti-proliferative effect of isorhamnetin on HeLa cells through inducing G2/M cell cycle arrest

2018 ◽  
Author(s):  
Juan Wei ◽  
Hailan Su ◽  
Yang Bi ◽  
Jixin Li ◽  
Lidan Feng ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Hela Cells ◽  
M Cell ◽  
Proliferative Effect ◽  
Cycle Arrest

p38–NF-κB-promoted mitochondria-associated apoptosis and G2/M cell cycle arrest in norcantharidin-treated HeLa cells

2012 ◽  
Vol 14 (11) ◽  
pp. 1008-1019 ◽  
Author(s):  
Xiu Dong ◽  
Jian-Chun Li ◽  
Yuan-Yuan Jiang ◽  
Ming-Yu Xia ◽  
Shin-Ichi Tashiro ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Hela Cells ◽  
M Cell ◽  
Cycle Arrest

scholarly journals Fisetin induces G2/M phase cell cycle arrest by inactivating cdc25C-cdc2 via ATM-Chk1/2 activation in human endometrial cancer cells

2015 ◽  
Vol 10 (2) ◽  
pp. 279 ◽  
Author(s):  
Zan-Ying Wang ◽  
Wen-Qiong Liu ◽  
Si’e Wang ◽  
Zeng-Tao Wei
Keyword(s):  
Cell Cycle ◽  
Endometrial Cancer ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Cyclin B1 ◽  
Phase Cell ◽  
M Cell ◽  
Proliferative Effect ◽  
Cycle Arrest ◽  
M Phase

<p>Endometrial cancer is one of the most prevalent gynaecological malignancies where, currently available therapeutic options remain limited. Recently phytochemicals are exploited for their efficiency in cancer therapy. The present study investigates the anti-proliferative effect of fisetin, a flavonoid on human endometrial cancer cells (KLE and Hec1 A). Fisetin (20-100 µM) effectively reduced the viability of Hec1 A and KLE cells and potentially altered the cell population at G2/M stage. Expression levels of the cell cycle proteins (cyclin B1, p-Cdc2, p-Cdc25C, p-Chk1, Chk2, p-ATM, cyclin B1, H2AX, p21 and p27) were analyzed. Fisetin suppressed cyclin B1 expression and caused inactiva-tion of Cdc25C and Cdc2 by increasing their phosphorylation levels and further activated ATM, Chk1 and Chk2. Increased levels of p21 and p27 were observed as well. These results suggest that fisetin induced G2/M cell cycle arrest via inactivating Cdc25c and Cdc2 through activation of ATM, Chk1 and Chk2.</p><p> </p><p> </p>

scholarly journals Euphornin reduces proliferation of human cervical adenocarcinoma HeLa cells through induction of apoptosis and G2/M cell cycle arrest

2018 ◽  
Vol Volume 11 ◽  
pp. 4395-4405 ◽  
Author(s):  
Xiao-Qiang Li ◽  
Yin-Liang Bai ◽  
De-Li Zhang ◽  
Hai-Sheng Jiao ◽  
Rong-Xia He
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Hela Cells ◽  
Cervical Adenocarcinoma ◽  
M Cell ◽  
Cycle Arrest ◽  
Induction Of Apoptosis

Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells

2010 ◽  
Vol 287 (2) ◽  
pp. 231-239 ◽  
Author(s):  
Soon Young Shin ◽  
Yeonjoong Yong ◽  
Chang Gun Kim ◽  
Young Han Lee ◽  
Yoongho Lim
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Hela Cells ◽  
M Cell ◽  
Cycle Arrest
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