scholarly journals Euphornin reduces proliferation of human cervical adenocarcinoma HeLa cells through induction of apoptosis and G2/M cell cycle arrest

2018 ◽  
Vol Volume 11 ◽  
pp. 4395-4405 ◽  
Author(s):  
Xiao-Qiang Li ◽  
Yin-Liang Bai ◽  
De-Li Zhang ◽  
Hai-Sheng Jiao ◽  
Rong-Xia He
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Hela Cells ◽  
Cervical Adenocarcinoma ◽  
M Cell ◽  
Cycle Arrest ◽  
Induction Of Apoptosis

scholarly journals Induction of Apoptosis and Cell Cycle Arrest in Human Colon Carcinoma Cells by Corema album Leaves

2014 ◽  
Vol 9 (1) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Antonio J. León-González ◽  
Margaret M. Manson ◽  
Miguel López-Lázaro ◽  
Inmaculada Navarro ◽  
Carmen Martín-Cordero
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Human Colon ◽  
Active Fraction ◽  
M Cell ◽  
Colon Carcinoma Cells ◽  
Cycle Arrest ◽  
Colon Cancer Cell Lines ◽  
Induction Of Apoptosis ◽  
Atlantic Coastal

The leaves of Corema album (Ericaceae), an endemic shrub which grows in Atlantic coastal areas of the Iberian Peninsula, are rich in flavonoids and other secondary metabolites. Silica gel column chromatography of the ethyl acetate extract from dried leaves was performed and a flavonic active fraction was obtained. The cytotoxic activity of this fraction was assessed using the colon cancer cell lines HCT116 and HT29. After 48 hours of treatment, cell viability was determined with luminescence-based ATPLite assay, showing IC50 values of 7.2 ± 0.7 and 6.8 ± 1.2 μg/mL, respectively. The study by flow cytometry revealed that the cytotoxicity of this fraction was mediated, at least in part, by induction of apoptosis and G2/M cell cycle arrest. The active fraction was then subjected to Sephadex LH-20 chromatography and two flavonoids were separated and identified as the flavanone pinocembrin and 2′,4′-dihydroxychalcone after UV, MS and NMR analysis.

G2/M cell cycle arrest and induction of apoptosis by a stilbenoid, 3,4,5-trimethoxy-4′-bromo-cis-stilbene, in human lung cancer cells

Life Sciences ◽  
2004 ◽  
Vol 75 (23) ◽  
pp. 2829-2839 ◽  
Author(s):  
Eun-Jin Lee ◽  
Hye-Young Min ◽  
Hyen Joo Park ◽  
Hwa-Jin Chung ◽  
Sanghee Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Human Lung ◽  
Human Lung Cancer ◽  
M Cell ◽  
Cycle Arrest ◽  
Human Lung Cancer Cells ◽  
Induction Of Apoptosis

scholarly journals Dillenia suffruticosa exhibited antioxidant and cytotoxic activity through induction of apoptosis and G2/M cell cycle arrest

2013 ◽  
Vol 146 (2) ◽  
pp. 525-535 ◽  
Author(s):  
Nurdin Armania ◽  
Latifah Saiful Yazan ◽  
Siti Noorhidayah Musa ◽  
Intan Safinar Ismail ◽  
Jhi Biau Foo ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cytotoxic Activity ◽  
Cell Cycle Arrest ◽  
M Cell ◽  
Cycle Arrest ◽  
Induction Of Apoptosis

scholarly journals EVALUATION OF THE ANTICANCER PROPERTIES OF TURMESAC® IN HUMAN CERVICAL ADENOCARCINOMA

2020 ◽  
pp. 109-113
Author(s):  
FIROZ HM ◽  
NANJUNDAIAH S ◽  
SADASHIVA CT
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Hela Cells ◽  
Anticancer Agent ◽  
Cervical Adenocarcinoma ◽  
Apoptosis Induction ◽  
Anticancer Properties ◽  
Cycle Arrest ◽  
Diphenyltetrazolium Bromide ◽  
Ic50 Value

Objective: In the current study, an extract of turmeric rhizome (Turmesac®) was evaluated for possible anticancer activity in human cervical adenocarcinoma (HeLa) cells. Methods: Turmesac®’s ability to elicit cytotoxicity in cancer cells was evaluated by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay (MTT) assay, where the IC50 value was determined. Apoptosis induction and cell cycle arrest were analyzed by flow cytometry post-Turmesac® IC50 value treatment for 24 h. Results: The determined IC50 value of Turmesac® in HeLa cells was 115.12 μg/ml. This concentration was able to induce apoptosis 2 times greater than the apoptotic standard, camptothecin, treated cells. Cell cycle arrest was observed at the G0/G1 and S phases in Turmesac® treated HeLa cells. Conclusion: Turmesac® shows the potential of being a promising anticancer agent that may be incorporated into chemotherapies, but further study is required to elucidate the exact mechanisms involved with longer treatment duration, as would be the case in clinical trial phases.

p38–NF-κB-promoted mitochondria-associated apoptosis and G2/M cell cycle arrest in norcantharidin-treated HeLa cells

2012 ◽  
Vol 14 (11) ◽  
pp. 1008-1019 ◽  
Author(s):  
Xiu Dong ◽  
Jian-Chun Li ◽  
Yuan-Yuan Jiang ◽  
Ming-Yu Xia ◽  
Shin-Ichi Tashiro ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Hela Cells ◽  
M Cell ◽  
Cycle Arrest

scholarly journals Induction of Apoptosis and G2/M Cell Cycle Arrest by Cordycepin in Human Prostate Carcinoma LNCap Cells

2014 ◽  
Vol 24 (1) ◽  
pp. 92-97 ◽  
Author(s):  
Hye Hyeon Lee ◽  
Won Deok Hwang ◽  
Jin-Woo Jeong ◽  
Cheol Park ◽  
Min Ho Han ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Prostate Carcinoma ◽  
Human Prostate ◽  
Lncap Cells ◽  
M Cell ◽  
Cycle Arrest ◽  
Human Prostate Carcinoma ◽  
Induction Of Apoptosis
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