scholarly journals Treatment of radiation-induced acute intestinal injury with bone marrow-derived mesenchymal stem cells

2016 ◽  
Vol 11 (6) ◽  
pp. 2425-2431 ◽  
Author(s):  
KAI ZHENG ◽  
WEIZHEN WU ◽  
SHUNLIANG YANG ◽  
LIANGHU HUANG ◽  
JIN CHEN ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Intestinal Injury ◽  
Radiation Induced

Directional delivery of RSPO1 by mesenchymal stem cells ameliorates radiation-induced intestinal injury

Cytokine ◽  
2017 ◽  
Vol 95 ◽  
pp. 27-34 ◽  
Author(s):  
Wei Chen ◽  
Songwen Ju ◽  
Ting Lu ◽  
Yongfang Xu ◽  
Xiaocui Zheng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Intestinal Injury ◽  
Radiation Induced

scholarly journals Therapeutic effects of bone marrow-derived mesenchymal stem cells on radiation-induced lung injury

2015 ◽  
Vol 35 (2) ◽  
pp. 731-738 ◽  
Author(s):  
CHENGCHENG XIA ◽  
PENGYU CHANG ◽  
YUYU ZHANG ◽  
WEIYAN SHI ◽  
BIN LIU ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Lung Injury ◽  
Therapeutic Effects ◽  
Radiation Induced

scholarly journals Transplantation of Mesenchymal Stem Cells to Prevent Radiation-induced Intestinal Injury in Mice

2010 ◽  
Vol 51 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Kohsei KUDO ◽  
Yong LIU ◽  
Kenji TAKAHASHI ◽  
Kohetsu TARUSAWA ◽  
Minoru OSANAI ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Intestinal Injury ◽  
Radiation Induced

scholarly journals Effect of Bone Marrow and Adipose Mesenchymal Stem Cells on Rat Intestinal Injury Induced by Methotrexate

2018 ◽  
Vol 1 (2) ◽  
pp. 1-11
Author(s):  
Marwa A. Masoud ◽  
Eman G. Mohamed ◽  
Wedad A. Hassan ◽  
Ebtehal Mohammad F
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Radical Scavenging ◽  
Intestinal Injury ◽  
Control Group ◽  
Therapeutic Effects ◽  
Myeloperoxidase Activity ◽  
Marrow Mesenchymal Stem Cells ◽  
Nitrite Nitrate

Methotrexate (MTX) is an anti-metabolite in cancer chemotherapy and is associated with various toxicities assigned to inflammation and oxidative stress. The present study was undertaken to corroborate the therapeutic effects of bone marrow mesenchymal stem cells (BM-MSCs) and adipose-derived mesenchymal stem cells (AD-MSCs) in MTX-induced intestinal toxicity in experimental animals as compared with dexamethasone (Dex). Rats were divided into five groups: I-Normal control group, II- MTX (14 mg/kg, as a single dose/week for 2 weeks), III & IV- BM-MSCs & AD-MSCs (2 × 106 cells/rat, 1 week after last dose of MTX), respectively, plus V- Dex (0.5 mg/kg/ for 7 days, 1 week after last dose of MTX). MTX induced marked intestinal elevation of interleukin-6, total oxidant, and nitrite/ nitrate, caspase-3 contents and myeloperoxidase activity, along with the reduction of reduced glutathione content and catalase activity. In conclusion, the positive modulation of MTX toxicity could be attributed to the free radical scavenging, anti-inflammatory and antiapoptotic potential of BM-MSC and AD-MSCs which will possibly make them as remarkable hopeful for the treatment of intestinal injury.

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