scholarly journals Therapeutic effects of bone marrow-derived mesenchymal stem cells on radiation-induced lung injury

2015 ◽  
Vol 35 (2) ◽  
pp. 731-738 ◽  
Author(s):  
CHENGCHENG XIA ◽  
PENGYU CHANG ◽  
YUYU ZHANG ◽  
WEIYAN SHI ◽  
BIN LIU ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Lung Injury ◽  
Therapeutic Effects ◽  
Radiation Induced

scholarly journals Therapeutic Effects of Bone Marrow-Derived Mesenchymal Stem Cells in Models of Pulmonary and Extrapulmonary Acute Lung Injury

2015 ◽  
Vol 24 (12) ◽  
pp. 2629-2642 ◽  
Author(s):  
Ling Liu ◽  
Hongli He ◽  
Airan Liu ◽  
Jingyuan Xu ◽  
Jibin Han ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Therapeutic Effects

Therapeutic Effects of Bone Marrow-Derived Mesenchymal Stem Cells Engraftment on Bleomycin-Induced Lung Injury in Rats

2008 ◽  
Vol 40 (5) ◽  
pp. 1700-1705 ◽  
Author(s):  
F. Zhao ◽  
Y.F. Zhang ◽  
Y.G. Liu ◽  
J.J. Zhou ◽  
Z.K. Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Lung Injury ◽  
Therapeutic Effects

scholarly journals CXCR4-Overexpressing Umbilical Cord Mesenchymal Stem Cells Enhance Protection against Radiation-Induced Lung Injury

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Chunyang Zhang ◽  
Yan Zhu ◽  
Ji Wang ◽  
Lisheng Hou ◽  
Wei Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Lung Injury ◽  
Umbilical Cord ◽  
Saline Control ◽  
Human Umbilical Cord ◽  
Therapeutic Effects ◽  
X Rays ◽  
Thoracic Irradiation ◽  
Radiation Induced

Less quantity of transplanted mesenchymal stem cells (MSCs) influences the therapeutic effects on radiation-induced lung injury (RILI). Previous studies have demonstrated that MSCs overexpressing Chemokine (C-X-C motif) receptor 4 (CXCR4) could increase the quantity of transplanted cells to local tissues. In the present study, we conducted overexpressing CXCR4 human umbilical cord mesenchymal stem cell (HUMSC) therapy for RILI. C57BL mice received single dose of thoracic irradiation with 13 Gy of X-rays and then were administered saline, control HUMSCs, or CXCR4-overexpressing HUMSCs via tail vein. Transfection with CXCR4 enhanced the quantity of transplanted HUMSCs in the radiation-induced injured lung tissues. CXCR4-overexpressing HUMSCs not only improved histopathological changes but also decreased the radiation-induced expression of SDF-1, TGF-β1, α-SMA, and collagen I and inhibited the radiation-induced decreased expression of E-cadherin. Transplanted CXCR4-overexpressing HUMSCs also could express pro-SP-C, indicated adopting the feature of ATII. These finding suggests that CXCR4-overexpressing HUMSCs enhance the protection against RILI and may be a promising strategy for RILI treatment.

scholarly journals Therapeutic effects of bone marrow mesenchymal stem cells‐derived exosomes on osteoarthritis

2021 ◽  
Vol 25 (19) ◽  
pp. 9281-9294
Author(s):  
Yi Jin ◽  
Min Xu ◽  
Hai Zhu ◽  
Chen Dong ◽  
Juan Ji ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Effects ◽  
Marrow Mesenchymal Stem Cells
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