scholarly journals Therapeutic potential of caffeic acid phenethyl ester and its anti-inflammatory and immunomodulatory effects (Review)

2015 ◽  
Vol 9 (5) ◽  
pp. 1582-1588 ◽  
Author(s):  
FERAH ARMUTCU ◽  
SUMEYYA AKYOL ◽  
SEYFETTIN USTUNSOY ◽  
FATIME FILIZ TURAN
Keyword(s):  
Caffeic Acid ◽  
Therapeutic Potential ◽  
Caffeic Acid Phenethyl Ester ◽  
Immunomodulatory Effects ◽  
Anti Inflammatory

Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights

2021 ◽  
Vol 19 ◽  
Author(s):  
Namrata Pramod Kulkarni ◽  
Bhupesh Vaidya ◽  
Acharan Narula ◽  
Shyam Sunder Sharma
Keyword(s):  
Caffeic Acid ◽  
Neurological Disorders ◽  
Therapeutic Potential ◽  
Caffeic Acid Phenethyl Ester ◽  
Depression And Anxiety ◽  
Age Related ◽  
Anti Cancer ◽  
Therapeutic Molecules ◽  
Conifer Trees ◽  
Lateral Sclerosis

: Neurological disorders like Alzheimer’s disease (AD), Parkinson’s disease (PD), stroke, amyotrophic lateral sclerosis, Huntington’s disease (HD), epilepsy, traumatic brain injury (TBI), depression and anxiety are responsible for thousands of deaths worldwide every year. With the increase in life expectancy, there has been a rise in the prevalence of these disorders. Age is one of the major risk factors for these neurological disorders and with the aged population is set to rise to 1.25 billion by 2050. There is a growing concern to look for new therapeutic molecules to treat age-related diseases. Caffeic acid phenethyl ester (CAPE) is a molecule obtained from a number of botanical sources such as the bark of conifer trees as well as propolis which is extracted from beehives. Though CAPE remains relatively unexplored in human trials, it possesses antioxidant, anti-inflammatory, antimitogenic and anti-cancer activities as shown by preclinical studies. Apart from this, it also exhibits tremendous potential for the treatment of neurological disorders through modulation of multiple molecular pathways and attenuation of behavioural deficits. In the present article, we have reviewed the therapeutic potential of CAPE and its mechanisms in the treatment of neurological disorders.

scholarly journals Caffeic Acid Phenethyl Ester Attenuates Gingival Tissue Inflammation in Experimental Periodontitis

2021 ◽  
Author(s):  
Esra DEMİR ◽  
Feyza Otan ÖZDEN ◽  
Bahattin AVCI
Keyword(s):  
Caffeic Acid ◽  
Alveolar Bone ◽  
Caffeic Acid Phenethyl Ester ◽  
Gingival Tissue ◽  
Dependent Manner ◽  
Tnf Α ◽  
Significant Difference ◽  
Experimental Periodontitis ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Abstract Caffeic acid phenethyl ester (CAPE) is an active component of propolis extracts and has anti-inflammatory, antioxidant, immunomodulatory activities. This study aims to investigate the anti-inflammatory effect of two different dosages of CAPE on lipopolysaccharide-induced experimental periodontitis (EP). Forty Sprague Dawley rats were randomly divided into four groups: control, EP, EP treated with 5 µmol/kg/day of CAPE (EP + CAPE 5), and EP treated with 10 µmol/kg/day of CAPE (EP + CAPE 10). Followed by the EP, CAPE was administered intraperitoneally to the EP + CAPE groups for 28 days. Samples were investigated biochemically using an enzyme linked immunoassay (ELISA) kit and alveolar bone loss was measured morphometrically. In both of the CAPE groups, the levels of IL-1β and TNF-α in the gingiva were significantly lower than those in the EP group (p < 0.001). The decrease in tissue levels of TNF-α was greater in the EP + CAPE 10 group than in the EP + CAPE 5 group in a dose-dependent manner. Serum analysis of the cytokines showed no significant difference between the groups. Within the limits of this study, CAPE showed its anti-inflammatory effect by reducing pro-inflammatory cytokines in gingiva and is claimed to be a novel agent in improving the results of periodontal therapy without any known side effects.

scholarly journals Adipose Tissue-Derived Stem Cells: Immunomodulatory Effects and Therapeutic Potential

Physiology ◽  
2020 ◽  
Vol 35 (2) ◽  
pp. 125-133 ◽  
Author(s):  
Sara Al-Ghadban ◽  
Bruce A. Bunnell
Keyword(s):  
Stem Cells ◽  
Therapeutic Potential ◽  
Mechanisms Of Action ◽  
Adipose Derived Stem Cells ◽  
Immunomodulatory Effects ◽  
Graft Versus Host ◽  
Cell Lineages ◽  
Pathological Conditions ◽  
Multiple Cell ◽  
Anti Inflammatory

Adipose-derived stem cells (ASCs) can self-renew and differentiate along multiple cell lineages. ASCs are also potently anti-inflammatory due to their inherent ability to regulate the immune system by secreting anti-inflammatory cytokines and growth factors that play a crucial role in the pathology of many diseases, including multiple sclerosis, diabetes mellitus, Crohn’s, SLE, and graft-versus-host disease. The immunomodulatory effects and mechanisms of action of ASCs on pathological conditions are reviewed here.

scholarly journals Caffeic Acid Phenethyl Ester: Consequences of Its Hydrophobicity in the Oxidative Functions and Cytokine Release by Leukocytes

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Luana Chiquetto Paracatu ◽  
Carolina Maria Quinello Gomes Faria ◽  
Camila Quinello ◽  
Camila Rennó ◽  
Patricia Palmeira ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Caffeic Acid ◽  
Superoxide Anion ◽  
Hypochlorous Acid ◽  
Inflammatory Diseases ◽  
Biological Effects ◽  
Caffeic Acid Phenethyl Ester ◽  
Nadph Oxidases ◽  
Tnf Α ◽  
Anti Inflammatory

Numerous anti-inflammatory properties have been attributed to caffeic acid phenethyl ester (CAPE), an active component of propolis. NADPH oxidases are multienzymatic complexes involved in many inflammatory diseases. Here, we studied the importance of the CAPE hydrophobicity on cell-free antioxidant capacity, inhibition of the NADPH oxidase and hypochlorous acid production, and release of TNF-α and IL-10 by activated leukocytes. The comparison was made with the related, but less hydrophobic, caffeic and chlorogenic acids. Cell-free studies such as superoxide anion scavenging assay, triene degradation, and anodic peak potential(Epa)measurements showed that the alterations in the hydrophobicity did not provoke significant changes in the oxidation potential and antiradical potency of the tested compounds. However, only CAPE was able to inhibit the production of superoxide anion by activated leukocytes. The inhibition of the NADPH oxidase resulted in the blockage of production of hypochlorous acid. Similarly, CAPE was the more effective inhibitor of the release of TNF-α and IL-10 byStaphylococcus aureusstimulated cells. In conclusion, the presence of the catechol moiety and the higher hydrophobicity were essential for the biological effects. Considering the involvement of NADPH oxidases in the genesis and progression of inflammatory diseases, CAPE should be considered as a promising anti-inflammatory drug.

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