Anti-inflammatory effects of caffeic acid phenethyl ester (CAPE), a nuclear factor-κB inhibitor, onHelicobacter pylori-induced gastritis in Mongolian gerbils

2009 ◽  
Vol 125 (8) ◽  
pp. 1786-1795 ◽  
Author(s):  
Takeshi Toyoda ◽  
Tetsuya Tsukamoto ◽  
Shinji Takasu ◽  
Liang Shi ◽  
Naoki Hirano ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Nuclear Factor Κb ◽  
Caffeic Acid Phenethyl Ester ◽  
Mongolian Gerbils ◽  
Nuclear Factor ◽  
Anti Inflammatory

scholarly journals Inhibition of nuclear factor-κB p65 phosphorylation by 3,4-dihydroxybenzalacetone and caffeic acid phenethyl ester

2018 ◽  
Vol 137 (3) ◽  
pp. 248-255 ◽  
Author(s):  
Ken Takakura ◽  
Shouhei Takatou ◽  
Ryoichi Tomiyama ◽  
Thuong Manh Le ◽  
Dinh Thi Nguyen ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Nuclear Factor Κb ◽  
Caffeic Acid Phenethyl Ester ◽  
Nuclear Factor

scholarly journals Caffeic acid phenethyl ester reduces the activation of the nuclear factor κB pathway by high-fat diet-induced obesity in mice

Metabolism ◽  
2012 ◽  
Vol 61 (11) ◽  
pp. 1606-1614 ◽  
Author(s):  
Rosângela Maria Neves Bezerra ◽  
Lucimara Fernanda Veiga ◽  
Aline Camila Caetano ◽  
Pedro Luiz Rosalen ◽  
Maria Esméria Corezola Amaral ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
High Fat Diet ◽  
Nuclear Factor Κb ◽  
Caffeic Acid Phenethyl Ester ◽  
Nuclear Factor ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice

scholarly journals Nuclear Factor-κB Inhibitors as Potential Novel Anti-Inflammatory Agents for the Treatment of Immune Glomerulonephritis

2002 ◽  
Vol 161 (4) ◽  
pp. 1497-1505 ◽  
Author(s):  
Oscar López-Franco ◽  
Yusuke Suzuki ◽  
Guillermo Sanjuán ◽  
Julia Blanco ◽  
Purificación Hernández-Vargas ◽  
...  
Keyword(s):  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Anti Inflammatory

scholarly journals Biological Evaluation of Alkyl Triphenylphosphonium Ostruthin Derivatives as Potential Anti-Inflammatory Agents Targeting the Nuclear Factor κB Signaling Pathway in Human Lung Adenocarcinoma A549 Cells

BioChem ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 107-121
Author(s):  
Nghia Trong Vo ◽  
Eiichi Kusagawa ◽  
Kaori Nakano ◽  
Chihiro Moriwaki ◽  
Yasunobu Miyake ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Signaling Pathway ◽  
Human Lung ◽  
A549 Cells ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Human Lung Adenocarcinoma ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Lung Adenocarcinoma A549

Ostruthin (6-geranyl-7-hydroxycoumarin) is one of the constituents isolated from Paramignya trimera and has been classified as a simple coumarin. We recently reported the synthesis of alkyl triphenylphosphonium (TPP) derivatives from ostruthin and evaluated their anticancer activities. In the present study, we demonstrated that alkyl TPP ostruthin derivatives inhibited the up-regulation of cell-surface intercellular adhesion molecule-1 (ICAM-1) in human lung adenocarcinoma A549 cells stimulated with tumor necrosis factor-α (TNF-α) without affecting cell viability, while ostruthin itself exerted cytotoxicity against A549 cells. The heptyl TPP ostruthin derivative (termed OS8) attenuated the up-regulation of ICAM-1 mRNA expression at concentrations higher than 40 µM in TNF-α-stimulated A549 cells. OS8 inhibited TNF-α-induced nuclear factor κB (NF-κB)-responsive luciferase reporter activity at concentrations higher than 40 µM, but did not affect the translocation of the NF-κB subunit RelA in response to the TNF-α stimulation at concentrations up to 100 µM. A chromatin immunoprecipitation assay showed that OS8 at 100 µM prevented the binding of RelA to the ICAM-1 promoter. We also showed that OS8 at 100 µM inhibited the TNF-α-induced phosphorylation of RelA at Ser 536. Moreover, the TNF-α-induced phosphorylation of an inhibitor of NF-κB α and extracellular signal-regulated kinase was reduced by OS8. These results indicate that OS8 has potential as an anti-inflammatory agent that targets the NF-κB signaling pathway.

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