scholarly journals Emulsified isoflurane anesthesia decreases brain-derived neurotrophic factor expression and induces cognitive dysfunction in adult rats

2014 ◽  
Vol 8 (2) ◽  
pp. 471-477 ◽  
Author(s):  
FAN ZHANG ◽  
ZHAO-QIONG ZHU ◽  
DE-XING LIU ◽  
CHAO ZHANG ◽  
QI-HAI GONG ◽  
...  
Keyword(s):  
Cognitive Dysfunction ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Adult Rats ◽  
Isoflurane Anesthesia ◽  
Factor Expression

scholarly journals Stress and Inflammation Reduce Brain-Derived Neurotrophic Factor Expression in First-Episode Psychosis

2011 ◽  
Vol 72 (12) ◽  
pp. 1677-1684 ◽  
Author(s):  
Valeria Mondelli ◽  
Annamaria Cattaneo ◽  
Martino Belvederi Murri ◽  
Marta Di Forti ◽  
Rowena Handley ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Factor Expression

Forced running exercise mitigates radiation-induced cognitive deficits via regulated DNA hydroxymethylation

Epigenomics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 385-396 ◽  
Author(s):  
Junjun Zhang ◽  
Junyan Li ◽  
Yiwen Zhu ◽  
Zhigang Miao ◽  
Ye Tian
Keyword(s):  
Cognitive Dysfunction ◽  
Neurotrophic Factor ◽  
Epigenetic Modification ◽  
Brain Derived Neurotrophic Factor ◽  
Hippocampal Neurogenesis ◽  
Mice Model ◽  
Whole Brain Irradiation ◽  
Running Exercise ◽  
Radiation Induced ◽  
Forced Running

Aim: Roles of forced running exercise (FE) in remediation of neurogenesis inhibition and radiation-induced cognitive dysfunction were investigated in a whole-brain irradiation mice model via the regulation of DNA 5-hydroxymethylation modification (5 hmC) and its catalytic enzymes ten–eleven translocation (Tet) proteins. Materials & methods: Hippocampal neurogenesis and cognitive function, DNA 5 hmC level and Tet expression were determined in mice. Results: The expression of DNA 5 hmC and Tet2, brain-derived neurotrophic factor significantly decreased in hippocampus postradiation. FE mitigated radiation-induced neurogenesis deficits and cognitive dysfunction. Furthermore, FE increased 5 hmC and brain-derived neurotrophic factor expression. SC1, a Tet inhibitor, reversed partly such changes. Conclusion: Tet-mediated 5 hmC modification represents a kind of diagnostic biomarkers of radiation-induced cognitive dysfunction. Targeting Tet-related epigenetic modification may be a novel therapeutic strategy for radiation-induced brain injury.

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