scholarly journals Possibility of molecular targeting therapy for the treatment of cancer of unknown primary origin by analysis of intracellular signaling molecules

2011 ◽  
Vol 3 (3) ◽  
pp. 547-549 ◽  
Author(s):  
SHOICHIRO OHTA ◽  
YUKIKO CHO ◽  
MASAHARU SHIBATA ◽  
KIMIHIRO NAGAI ◽  
TATSUO IIJIMA ◽  
...  
Keyword(s):  
Intracellular Signaling ◽  
Signaling Molecules ◽  
Cancer Of Unknown Primary ◽  
Molecular Targeting ◽  
Unknown Primary ◽  
Targeting Therapy ◽  
Molecular Targeting Therapy ◽  
Primary Origin ◽  
Intracellular Signaling Molecules ◽  
Unknown Primary Origin

scholarly journals Expression of Glycolysis-Related Proteins in Cancer of Unknown Primary Origin

2021 ◽  
Vol 11 ◽  
Author(s):  
Murilo Bonatelli ◽  
Isabella Fernandes Fornari ◽  
Priscila Neves Bernécule ◽  
Lara Esquiapatti Pinheiro ◽  
Ricardo Filipe Alves Costa ◽  
...  
Keyword(s):  
Overall Survival ◽  
Lymph Nodes ◽  
Glucose Transporter ◽  
Metastatic Cancer ◽  
Multivariable Analysis ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Primary Origin ◽  
Related Proteins ◽  
Unknown Primary Origin

IntroductionCancer of unknown primary origin (CUP) is defined as metastatic cancer without identification of the primary site. Considering that only 15–20% of patients with CUP show a favorable outcome, identifying biomarkers may help improve the clinical management of patients who do not respond well to conventional therapies. In this context, the study of the metabolic profile of CUP may pave the way to establish new biomarkers and/or therapeutic targets; therefore, this study aimed to characterize the expression of metabolism-related proteins in CUP.Materials and MethodsThe expression of monocarboxylate transporters MCT1, MCT2 and MCT4, their chaperone CD147, the glucose transporter GLUT1 and the pH regulator CAIX was evaluated by immunohistochemistry in a series of 118 CUP patients, and the results were associated with the available clinicopathological information.ResultsThe metabolism-related proteins MCT1, MCT4, CD147, GLUT1 and CAIX were expressed in a critical portion of the CUP (approximately 20 to 70%). MCT1 and CD147 were both more frequently expressed in cases with lymph nodes as metastasis dominant sites (p = 0.001) as well as in samples from lymph nodes (p <0.001 and p = 0.002, respectively), while MCT1 expression was more frequently expressed in squamous cell carcinomas (p = 0.045). A higher overall survival was observed in patients with tumors positive for GLUT1 and CAIX expression (p = 0.011 and p = 0.041, respectively), but none of the proteins was an independent prognostic factor for overall survival in multivariable analysis.ConclusionThe results suggest that a portion of CUPs present a hyperglycolytic phenotype, which is associated with higher overall survival.

scholarly journals Cancer of Unknown Primary Origin

1997 ◽  
Vol 2 (3) ◽  
pp. 142-152 ◽  
Author(s):  
Evangelos Briasoulis ◽  
Nicholas Pavlidis
Keyword(s):  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Primary Origin ◽  
Unknown Primary Origin

A new, palliative care led, pathway approach to care in metastatic cancer of unknown primary origin

2012 ◽  
Vol 2 (Suppl 1) ◽  
pp. A46.1-A46
Author(s):  
Philippa Hughes ◽  
Clare Farrington ◽  
David Brooks ◽  
Peter Bath ◽  
Bill Noble
Keyword(s):  
Palliative Care ◽  
Metastatic Cancer ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Primary Origin ◽  
Unknown Primary Origin

Cancer of Unknown Primary origin in the genomic era: Elucidating the dark box of cancer

2015 ◽  
Vol 41 (7) ◽  
pp. 598-604 ◽  
Author(s):  
Panagiota Economopoulou ◽  
Giannis Mountzios ◽  
Nicholas Pavlidis ◽  
George Pentheroudakis
Keyword(s):  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Primary Origin ◽  
Unknown Primary Origin

scholarly journals A Rare Case of Pembrolizumab-Induced Dermatomyositis in a Patient with Cancer of Unknown Primary Origin

2021 ◽  
Vol 22 ◽  
Author(s):  
Kensaku Takatsuki ◽  
Toyoshi Yanagihara ◽  
Ayaka Egashira ◽  
Naruhiko Ogo ◽  
Seiji Yoshizawa ◽  
...  
Keyword(s):  
Rare Case ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Primary Origin ◽  
Unknown Primary Origin

scholarly journals A Study on Cervical Lymph Node Metastasis from Cancer of Unknown Primary Origin

2014 ◽  
Vol 138 (0) ◽  
pp. 108-109
Author(s):  
Takashi Taniyama ◽  
Tomonori Sugiyama ◽  
Mamika Araki ◽  
Kouhei Fukukita ◽  
Hiroyuki Yamada ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cervical Lymph Node ◽  
Cervical Lymph Node Metastasis ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Node Metastasis ◽  
Primary Origin ◽  
Unknown Primary Origin
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