scholarly journals Alteration of P2X1‑6 receptor expression in retrograde Fluorogold‑labeled DRG neurons from rat chronic neuropathic pain model

2019 ◽  
Author(s):  
Changlong Leng ◽  
Lin Chen ◽  
Chaoying Li
Keyword(s):  
Neuropathic Pain ◽  
Receptor Expression ◽  
Drg Neurons ◽  
Chronic Neuropathic Pain ◽  
Pain Model ◽  
Neuropathic Pain Model

Pulsed magnetic field enhances therapeutic efficiency of mesenchymal stem cells in chronic neuropathic pain model

2017 ◽  
Vol 38 (4) ◽  
pp. 255-264 ◽  
Author(s):  
Tufan Mert ◽  
Akif Hakan Kurt ◽  
İdiris Altun ◽  
Ahmet Celik ◽  
Furkan Baran ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Neuropathic Pain ◽  
Pulsed Magnetic Field ◽  
Chronic Neuropathic Pain ◽  
Pain Model ◽  
Therapeutic Efficiency ◽  
Neuropathic Pain Model

Spinal Cord Stimulation in a Mouse Chronic Neuropathic Pain Model

2007 ◽  
Vol 10 (4) ◽  
pp. 358-362 ◽  
Author(s):  
M. Truin ◽  
P. van Venrooij ◽  
V. Duysens ◽  
R. Deumens ◽  
M. van Kleef ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Spinal Cord Stimulation ◽  
Chronic Neuropathic Pain ◽  
Pain Model ◽  
Neuropathic Pain Model

167 SPINAL CORD STIMULATION IN A MOUSE CHRONIC NEUROPATHIC PAIN MODEL

2007 ◽  
Vol 11 (S1) ◽  
pp. S72-S72
Author(s):  
M. Truin ◽  
Y. Verboeket ◽  
W. Honig ◽  
R. Deumens ◽  
M. Kleef ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Spinal Cord Stimulation ◽  
Chronic Neuropathic Pain ◽  
Pain Model ◽  
Neuropathic Pain Model

scholarly journals The Therapeutic Effectiveness of Full Spectrum Hemp Oil Using a Chronic Neuropathic Pain Model

Life ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 69 ◽  
Author(s):  
Jacob M. Vigil ◽  
Marena A. Montera ◽  
Nathan S. Pentkowski ◽  
Jegason P. Diviant ◽  
Joaquin Orozco ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Infraorbital Nerve ◽  
Chronic Neuropathic Pain ◽  
Full Spectrum ◽  
Pain Model ◽  
Post Surgery ◽  
Whole Plant ◽  
Neuropathic Pain Model ◽  
Whisker Pad ◽  
Hemp Oil

Background: Few models exist that can control for placebo and expectancy effects commonly observed in clinical trials measuring ‘Cannabis’ pharmacodynamics. We used the Foramen Rotundum Inflammatory Constriction Trigeminal Infraorbital Nerve injury (FRICT-ION) model to measure the effect of “full-spectrum” whole plant extracted hemp oil on chronic neuropathic pain sensitivity in mice. Methods: Male BALBc mice were submitted to the FRICT-ION chronic neuropathic pain model with oral insertion through an incision in the buccal/cheek crease of 3 mm of chromic gut suture (4-0). The suture, wedged along the V2 trigeminal nerve branch, creates a continuous irritation that develops into secondary mechanical hypersensitivity on the snout. Von Frey filament stimuli on the mouse whisker pad was used to assess the mechanical pain threshold from 0–6 h following dosing among animals (n = 6) exposed to 5 μL of whole plant extracted hemp oil combined with a peanut butter vehicle (0.138 mg/kg), the vehicle alone (n = 3) 7 weeks post-surgery, or a naïve control condition (n = 3). Results: Mechanical allodynia was alleviated within 1 h (d = 2.50, p < 0.001) with a peak reversal effect at 4 h (d = 7.21, p < 0.001) and remained significant throughout the 6 h observation window. There was no threshold change on contralateral whisker pad after hemp oil administration, demonstrating the localization of anesthetic response to affected areas. Conclusion: Future research should focus on how whole plant extracted hemp oil affects multi-sensory and cognitive-attentional systems that process pain.

scholarly journals The activation of galanin receptor 2 plays an antinociceptive effect in nucleus accumbens of rats with neuropathic pain

2021 ◽  
Vol 71 (1) ◽  
Author(s):  
Yan Dong ◽  
Chong-Yang Li ◽  
Xiao-Min Zhang ◽  
Ya-Nan Liu ◽  
Shuang Yang ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nucleus Accumbens ◽  
Pain Threshold ◽  
Antinociceptive Effect ◽  
Galanin Receptor ◽  
Pain Model ◽  
Withdrawal Threshold ◽  
Neuropathic Pain Model ◽  
Galanin Receptors ◽  
Intact Rats

AbstractOur previous research has shown that galanin plays an antinociceptive effect via binding to galanin receptors (GalRs) in nucleus accumbens (NAc). This study focused on the involvement of GalR2 in galanin-induced antinociceptive effect in NAc of neuropathic pain rats. The chronic constriction injury of sciatic nerve (CCI) was used to mimic neuropathic pain model. The hind paw withdrawal latency (HWL) to thermal stimulation and hind paw withdrawal threshold (HWT) to mechanical stimulation were measured as the indicators of pain threshold. The results showed that 14 and 28 days after CCI, the expression of GalR2 was up-regulated in bilateral NAc of rats, and intra-NAc injection of GalR2 antagonist M871 reversed galanin-induced increases in HWL and HWT of CCI rats. Furthermore, intra-NAc injection of GalR2 agonist M1145 induced increases in HWL and HWT at day 14 and day 28 after CCI, which could also be reversed by M871. Finally, we found that M1145-induced antinociceptive effect in NAc of CCI rats was stronger than that in intact rats. These results imply that the GalR2 is activated in the NAc from day 14 to day 28 after CCI and GalR2 is involved in the galanin-induced antinociceptive effect in NAc of CCI rats.

scholarly journals Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model

2021 ◽  
Vol 22 (5) ◽  
pp. 2479
Author(s):  
Amir Mohammadzadeh ◽  
Péter P. Lakatos ◽  
Mihály Balogh ◽  
Ferenc Zádor ◽  
Dávid Árpád Karádi ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Animal Studies ◽  
Acute Administration ◽  
Pain Model ◽  
Therapeutic Value ◽  
Small Doses ◽  
Function Test ◽  
Neuropathic Pain Model ◽  
First Time ◽  
Glycine Content

The limited effect of current medications on neuropathic pain (NP) has initiated large efforts to develop effective treatments. Animal studies showed that glycine transporter (GlyT) inhibitors are promising analgesics in NP, though concerns regarding adverse effects were raised. We aimed to study NFPS and Org-25543, GlyT-1 and GlyT-2 inhibitors, respectively and their combination in rat mononeuropathic pain evoked by partial sciatic nerve ligation. Cerebrospinal fluid (CSF) glycine content was also determined by capillary electrophoresis. Subcutaneous (s.c.) 4 mg/kg NFPS or Org-25543 showed analgesia following acute administration (30–60 min). Small doses of each compound failed to produce antiallodynia up to 180 min after the acute administration. However, NFPS (1 mg/kg) produced antiallodynia after four days of treatment. Co-treatment with subanalgesic doses of NFPS (1 mg/kg) and Org-25543 (2 mg/kg) produced analgesia at 60 min and thereafter meanwhile increased significantly the CSF glycine content. This combination alleviated NP without affecting motor function. Test compounds failed to activate G-proteins in spinal cord. To the best of our knowledge for the first time we demonstrated augmented analgesia by combining GlyT-1 and 2 inhibitors. Increased CSF glycine content supports involvement of glycinergic system. Combining selective GlyT inhibitors or developing non-selective GlyT inhibitors might have therapeutic value in NP.

Sign in / Sign up

Export Citation Format

Share Document